Diagnosis of mycotoxicoses : a publication based on the symposium on the diagnosis of mycotoxicoses of importance in the United States and Japan, sponsored by US-Japan cooperative program on development and utilization of natural resources, joint panel on

Current problems associated with the mycotoxicoses include the recognition of an animal disease as being a mycotoxicosis and confirmation of diagnosis of the mycotoxicosis by satisfactory laboratory methods. By gathering a vast amount of scientific literature, diagnosticians can provide themselves with suitable informa­ tion for making such a diagnosis. However, the increased number of reported intoxications caused by fungi, the wide range in diversity of disease conditions and the chemical compounds causing the mycotoxicoses, and the ever-changing and rapid developments in the technology of mycotoxin analysis has made the gathering and assimilation of sufficient information by the diagnostician an insurmountable task. This is the reason for development of the symposium and the publication of this book; the first time that the subject of diagnosis of mycotoxicoses has been assembled in a single publication and as a compilation of topic papers by experts in this subject area. The UJNR panel on toxic microorganisms is interested in all aspects of intox­ ications by microorganisms as evidenced by its annual joint meetings in either the United States or Japan and its involvement in sponsoring numerous symposia and several publications in this broad scientific area. The overall mission of the National Animal Disease Center includes research efforts in the improvement or establishment of diagnostic methods for animal diseases. The UJNR panel and the NADC provided the funds and encouragement for the development of a symposium on the diagnosis of mycotoxicoses in the United States and . Tapan. Front Matter....Pages I-XX Front Matter....Pages 1-1 Introduction to the diagnosis of mycotoxicoses....Pages 3-8 Front Matter....Pages 9-9 Occurrence and clinical manifestations of aflatoxicosis....Pages 11-29 Occurrence and clinical manifestations of trichothecene toxicoses and zearalenone toxicoses....Pages 31-42 Occurrence and clinical manifestations of ochratoxicosis....Pages 43-50 Occurrence of penitrem mycotoxins and clinical manifestations of penitrem intoxications....Pages 51-59 Occurrence and clinical manifestations of ergot and fescue toxicoses....Pages 61-74 Equine leucoencephalomalacia: an historical review....Pages 75-79 Occurrence and clinical manifestations of lupinosis and slaframine toxicosis....Pages 81-90 Occurrence and clinical manifestations of rubratoxins A and B and cyclopiazonic acid....Pages 91-99 Front Matter....Pages 101-101 Aflatoxin in milk....Pages 103-111 Comparative biochemical changes associated with the trichothecene toxicoses....Pages 113-123 Comparative biochemical changes associated with mycotoxicoses other than aflatoxicosis and trichothecene toxicosis....Pages 125-139 Front Matter....Pages 141-141 Immunomodulation in aflatoxicosis....Pages 143-148 Immunomodulation in mycotoxicoses other than aflatoxicosis....Pages 149-161 Immunochemical methods for diagnosis of mycotoxicoses....Pages 163-176 Front Matter....Pages 177-177 Comparative histopathologic changes in aflatoxicosis....Pages 179-189 Comparative pathologic changes in trichothecene toxicosis....Pages 191-194 Comparative pathologie changes in ochratoxicosis and citrinin toxicosis....Pages 195-204 Comparative histopathologic changes in cyclopiazonic acid toxicosis and rubratoxicosis....Pages 205-212 Fusarium moniliforme and zearalenone toxicoses in domestic animals: a review....Pages 213-235 Front Matter....Pages 237-237 A review of TLC and HPLC methods for analysis of aflatoxins in commodities....Pages 239-255 Thin-layer and high performance liquid chromatographic methods for the analysis of aflatoxins in animal tissues and fluids....Pages 257-269 TLC and HPLC methods for analysis of trichothecenes in commodities....Pages 271-281 Chromatography of mycotoxins of diagnostic significance other than trichothecenes and aflatoxins....Pages 283-297 Principles involved in the analysis of aflatoxin B-1 by gas chromatography — mass spectrometry....Pages 299-304 Gas chromatography/mass spectral analysis of trichothecenes....Pages 305-322 Mass spectroscopy of mycotoxins other than aflatoxins or trichothecenes....Pages 323-329 Front Matter....Pages 331-331 Bioassay systems and their use in the diagnosis of mycotoxicoses....Pages 333-378 Front Matter....Pages 379-379 Resumé and future needs in the diagnosis of mycotoxicoses....Pages 381-385 Back Matter....Pages 387-411 Symposium on the Diagnosis of Mycotoxicoses of Importance in the US and Japan, sponsored by US-Japan Cooperative Program on Development and Utilization of Natural Resources Joint Panel on Toxic Microorganism, and the National Animal Disease Center USDA, ARS, held at Ames, Iowa, Oct. 11-13, 1984