Diagnosis of Musculoskeletal Tumors and Tumor-like Conditions : Clinical, Radiological and Histological Correlations - The Rizzoli Case Archive

This book, now in a second revised edition, casts light on the often complex diagnosis of musculoskeletal tumors and tumor-like conditions by drawing on the experience of the Rizzoli Orthopedic Institute during more than 100 years of treatment and research in the field. The different entities are described from a multidisciplinary perspective, highlighting clinical, radiological, and histological correlations. Particular emphasis is placed on differential diagnosis, which often needs to take into account nontumoral conditions. The recent identification of further significant biological and genetic features, and the impact of these discoveries on the classification of round cell tumors, vascular lesions, and spindle/pleomorphic entities in bone, is also extensively discussed. The Rizzoli case archive dates back to September 1900 and contains the original material relating to more than 29,000 bone lesions and 11,000 soft tissue lesions__.__ It is a fabulously rich resource, and this book will be invaluable for pathologists, radiologists, and clinicians at all levels of experience. Front Matter ....Pages i-xx Front Matter ....Pages 1-1 Epidemiology of Bone Lesions (Piero Picci)....Pages 3-9 Classification of Primary Bone Lesions (Piero Picci, Marco Gambarotti, Alberto Righi)....Pages 11-12 General Principles of Bone Pathology (Marco Gambarotti, Alberto Righi)....Pages 13-14 Epidemiology of Soft Tissue Lesions (Piero Picci)....Pages 15-18 Classification of Soft Tissue Lesions and General Principles of Soft Tissue Pathology (Marta Sbaraglia, Marco Gambarotti, Alberto Righi, Angelo Paolo Dei Tos)....Pages 19-22 Molecular Alterations in Musculoskeletal Lesions (Marta Sbaraglia, Marco Gambarotti, Alberto Righi, Angelo Paolo Dei Tos)....Pages 23-26 General Principles of Imaging (Daniel Vanel)....Pages 27-30 Staging (Piero Picci)....Pages 31-33 Front Matter ....Pages 35-35 Simple Bone Cyst (Unicameral Bone Cyst) (Laura Campanacci)....Pages 37-39 Langerhans’ Cell Histiocytosis (Laura Campanacci)....Pages 41-45 Histiocytic Fibroma (Laura Campanacci)....Pages 47-50 Fibrous Dysplasia (Piero Picci)....Pages 51-54 Osteofibrous Dysplasia of Long Bones (Alberto Righi)....Pages 55-59 Desmoid Fibroma (Laura Campanacci)....Pages 61-63 Chondromas (Davide Maria Donati, Eric L. Staals)....Pages 65-73 Osteochondromas (Davide Maria Donati, Eric L. Staals)....Pages 75-80 Chondroblastoma (Eric L. Staals)....Pages 81-83 Chondromyxoid Fibroma (Eric L. Staals)....Pages 85-87 Osteoid Osteoma (Laura Campanacci)....Pages 89-92 Osteoblastoma (Laura Campanacci)....Pages 93-95 Aneurysmal Bone Cyst (ABC) (Laura Campanacci)....Pages 97-100 Giant Cell Tumor (Marco Manfrini)....Pages 101-105 Biology of Giant Cell Tumour (Maria Serena Benassi)....Pages 107-110 Other Rare Pseudotumoral Lesions (Alberto Righi)....Pages 111-113 Other Rare Benign Lesions (Alberto Righi)....Pages 115-117 Front Matter ....Pages 119-119 Myositis Ossificans (Tommaso Frisoni)....Pages 121-126 Pigmented Villonodular Synovitis and Giant Cell Tumor of the Tendon Sheaths (Tenosynovial Giant Cell Tumor) (Eric L. Staals)....Pages 127-129 Synovial Chondromatosis (Eric L. Staals)....Pages 131-133 Fibromatosis (All Types) (Davide Maria Donati, Tommaso Frisoni)....Pages 135-139 Lipomas (Giuseppe Bianchi)....Pages 141-143 Neurofibromas (Marco Gambarotti)....Pages 145-147 Schwannoma (Marco Gambarotti)....Pages 149-151 Other Rare Conditions of Pseudotumoral and Benign Lesions of Soft Tissues (Alberto Righi)....Pages 153-154 Front Matter ....Pages 155-155 Chondrosarcomas (CHS) (Davide Maria Donati, Giuseppe Bianchi)....Pages 157-179 Biology of Conventional Chondrosarcoma (Maria Serena Benassi)....Pages 181-183 Osteosarcomas (OS) (Piero Picci)....Pages 185-212 Biology of Osteosarcomas (Massimo Serra, Claudia Maria Hattinger)....Pages 213-215 Chemotherapy of Osteosarcoma (Stefano Ferrari, Emanuela Palmerini)....Pages 217-221 Small Blue Round Cell Tumors (Marco Manfrini, Marco Gambarotti)....Pages 223-231 Biology of Ewing Sarcoma (Katia Scotlandi)....Pages 233-235 Chemotherapy of Ewing Sarcoma (Stefano Ferrari, Emanuela Palmerini)....Pages 237-239 Fibroblastic/Myofibroblastic Tumors (Piero Picci, Angelo Paolo Dei Tos, Marco Gambarotti, Alberto Righi)....Pages 241-272 Nerve Sheath Tumor (Piero Picci, Angelo Paolo Dei Tos)....Pages 273-276 Smooth and Striated Muscle (Piero Picci, Angelo Paolo Dei Tos)....Pages 277-284 Sarcomas with Uncertain Differentiation (Marco Gambarotti, Alberto Righi)....Pages 285-298 Vascular Tumors (Alberto Righi)....Pages 299-315 Liposarcomas (Angelo Paolo Dei Tos, Marco Gambarotti, Alberto Righi)....Pages 317-322 Chemotherapy of Soft Tissue Sarcomas (Stefano Ferrari, Emanuela Palmerini)....Pages 323-325 Adamantinoma (Alberto Righi)....Pages 327-330 Notochordal Differentiation (Alberto Righi)....Pages 331-338 Other Rare Malignant Lesions (Marco Gambarotti, Alberto Righi)....Pages 339-342 Front Matter ....Pages 343-343 Primary Lymphoma of Bone (Marta Sbaraglia)....Pages 345-348 Multiple Myeloma (Marta Sbaraglia)....Pages 349-353 Hodgkin’s Disease in Bone (Marta Sbaraglia)....Pages 355-356 Metastatic Lesions (Marco Gambarotti, Marta Sbaraglia)....Pages 357-362 Drawing on the Rizzoli Orthopedic Institute's archive of more than 40,000 cases, this superb new resource includes invaluable biomolecular analyses. It covers a vast array of lesions, highlighting clinical, radiological, and histological correlations