Diagnosis and Treatment of Pulmonary Hypertension : From Bench to Bedside

This book focuses on pulmonary arterial hypertension (PAH, Group 1) and chronic thromboembolic pulmonary hypertension (CTEPH, Group 4) among the various groups of pulmonary hypertension (PH) whose classification was updated into five major categories at the 5th World Symposium held in Nice, France, in 2013. Readers will find recent progress, methods, and up-to-date information on PH mechanisms, diagnostic images, and treatment in the management of PH. This volume, with contributions by leading researchers worldwide in the field , consists of five parts, starting with the fundamentals of PH, then pathophysiology and genetics, treatment, and right ventricular function. Front Matter....Pages i-viii Front Matter....Pages 1-1 Clinical Classification....Pages 3-11 Diagnosis: Imaging....Pages 13-27 Front Matter....Pages 29-29 Pathogenic and Therapeutic Role of MicroRNA in Pulmonary Arterial Hypertension....Pages 31-54 Sex Hormones....Pages 55-65 Rho-Kinase as a Therapeutic Target for Pulmonary Hypertension....Pages 67-76 The Unique Property of the Pulmonary Artery Regarding the Smooth Muscle Effects of Proteinase-Activated Receptor 1: The Possible Contribution to the Pathogenesis of Pulmonary Hypertension....Pages 77-87 Animal Models with Pulmonary Hypertension....Pages 89-99 Human Pathology....Pages 101-113 Pathophysiology and Genetics: BMPR2....Pages 115-124 Front Matter....Pages 125-125 Prostacyclin....Pages 127-138 Targeting the NO-sGC-cGMP Pathway in Pulmonary Arterial Hypertension....Pages 139-151 Endothelin Receptor Antagonist....Pages 153-169 Lung Transplantation....Pages 171-182 Front Matter....Pages 183-183 Medical Therapy for Chronic Thromboembolic Pulmonary Hypertension....Pages 185-192 Balloon Pulmonary Angioplasty....Pages 193-202 Pulmonary Endarterectomy for Chronic Thromboembolic Pulmonary Hypertension....Pages 203-214 Front Matter....Pages 215-215 Right Ventricular Function....Pages 217-236