Diagnosis and Treatment of Parkinson's Disease - State of the Art (Journal of Neural Transmission. Supplementa)

Expert clinicians and basic scientists with a special interest in Parkinson’s disease review the current state of science and clinical therapeutics of the disease. Therefore these articles represent an authorative review of the current state of knowledge regarding preclinical course and symptomatology, subtypes with their impact on the pathology, genetic alterations, novel mechanisms of neuronal cell death, diagnostic tools and old and novel therapeutic approaches with respect to neuroprotection and neuroregeneration in Parkinson’s disease. Particular emphasis has been placed on a novel antiparkinsonian drug called budipine with various modes of action also influencing altered non dopaminergic systems in Parkinson’s disease. It is evident, that many questions on the cause, course and treatment of Parkinson’s disease are still unanswered and therefore the ideal way to treat a parkinsonian patient remains to be defined. Front Matter....Pages i-vii Post mortem studies in Parkinson’s disease — is it possible to detect brain areas for specific symptoms?....Pages 1-29 Pathogenesis and preclinical course of Parkinson’s disease....Pages 31-74 Clinical efficacy of budipine in Parkinson’s disease....Pages 75-82 Multiple mechanisms of action: the pharmacological profile of budipine....Pages 83-105 Parkinson’s disease: one disease entity or many?....Pages 107-111 Parkinson’s disease — a multifactorial neurodegenerative disorder....Pages 113-125 Mechanism and consequences of nerve cell death in Parkinson’s disease....Pages 127-137 Functional imaging of Parkinson’s disease: is it possible to detect brain areas for specific symptoms?....Pages 139-153 Multiple system atrophy....Pages 155-164 Tremorlytic activity of budipine in Parkinson’s disease....Pages 165-172 Current management of motor fluctuations in patients with advanced Parkinson’s disease treated chronically with levodopa....Pages 173-183 Differentiation of dopamine agonists and their role in the treatment of Parkinson’s disease....Pages 185-192 Free radical scavengers: chemical concepts and clinical relevance....Pages 193-210 Differential diagnosis of tremor....Pages 211-220 Edited By H. Przuntek And T. Muller. Includes Bibliographical References.