Diagnosis and Therapy of Malignant Lymphoma (Recent Results in Cancer Research, 46)

K. MUSSHOFF The group of diseases known as malignant lymphomas are, for a number of reasons, of equal interest to theoretical and clinical medicine. New findings in the fields of virology and immunology could conceivably shed some light on the so far unknown etiology of malignant lymphomas. A viral etiology could explain many of the dis­ parate findings with such a puzzling disease as lymphogranulomatosis, which shows both all the signs of malignancy, such as the characteristic Reed-Sternberg and Hodgkin cells and chromosome abnormalities, and those of an inflammatory disease, i.e. typical changes in the blood count and bone marrow and in the distribution of serum proteins. So far we have not been able to identify the etiology of this disease. However, clinical observations and pathomorphological investigations involving a joint effort by different branches of medicine have brought us closer to an understanding of the clinical picture. Descriptive anatomy has given us a clear picture of the regional distribution of the lymphatic system, which has long been neglected in the past. The introductory paper by Dr. S. KUBIK (Zurich), who has made valuable contributions to our knowl­ edge of the anatomy of the lymphatic system, deals with this subject. Front Matter....Pages I-X Opening Address....Pages 1-1 Introduction....Pages 2-4 The Anatomy of the Lymphatic System....Pages 5-17 A Functional Approach to the Classification of Malignant Lymphoma....Pages 18-30 The Unspecific Mesenchymal Reaction of the Liver in Patients with Hodgkin’s Disease....Pages 31-38 Unspecific Mesenchymal Reaction in Bone Marrow in Patients with Hogdkin’s Disease....Pages 39-44 The Specific Post-Capillary Venules of Lymphoglandular Tissue in Hodgkin’s Disease....Pages 45-47 Immunology and Immune Reactions in Malignant Lymphoma....Pages 48-54 Correlation between EBV Infections and Malignant Lymphomas....Pages 55-58 Epstein-Barr Virus (EBV) in Lymphoid Cells from Patients with Hodgkin’s Disease....Pages 59-61 Mediastinoscopy and Thoracoscopy....Pages 62-63 Roentgen Anatomy of the Lymphatic System....Pages 64-76 Lymphographie Differential Diagnosis in Malignant Lymphomas....Pages 77-88 Lymphography in Clinical Stage III Hodgkin’s Disease....Pages 89-93 Alterations in Pulmonary Diffusion Capacity after Lymphangiography....Pages 94-98 The Diagnostic Significance of Laparoscopy in Hodgkin’s Disease....Pages 99-106 Splenectomy....Pages 107-112 Changes in Blood Coagulation after Splenectomy....Pages 113-117 Staging Laparotomy and Splenectomy in Hodgkin’s Disease....Pages 118-122 Preliminary Results of Laparotomy with Splenectomy in Patients Previously Treated for Hodgkin’s Disease....Pages 123-127 Influence of Extensive Biopsy Sampling at Laparotomy on Planning of Radiotherapy in the Non-Hodgkin Lymphoma....Pages 128-132 Bone Marrow Biopsy in Malignant Lymphoma....Pages 133-140 Radioisotope Investigations in Malignant Lymphoma....Pages 141-147 Diagnosis of Malignant Lymphoma with 67 Gallium....Pages 148-152 Presentation and Progression of Hodgkin’s Disease....Pages 153-162 Reticulosarcoma and Lymphosarcoma, Pattern of Relapse and Spread....Pages 163-166 Staging in Malignant Lymphoma....Pages 167-175 Radiotherapy of Hodgkin’s Disease and Malignant Lymphomas....Pages 176-181 Chemotherapy and Radiotherapy in the Management of the Malignant Lymphomas....Pages 182-189 Clinical Trials of the European Organization for Research on Treatment of Cancer (E.O.R.T.C.)....Pages 190-194 The Curability of Hodgkin’s Disease....Pages 195-200 The Curability of Lympho- and Reticulosarcomas....Pages 201-205 Results of Therapy in Hodgkin’s Disease: Freiburg i. Br. 1964–1971....Pages 206-220 Radiotherapy of Reticulum-Cell Sarcoma....Pages 221-224 Radical Radiotherapy of Hodgkin’s Disease. Lund 1944–1956 and 1967–1971....Pages 225-228 Results of Radiotherapy of Malignant Lymphomas....Pages 229-232 Present Results in the Treatment of Malignant Lymphomas. Results Obtained in a Series of 317 Cases....Pages 233-239 Localization and Prognostic Importance of Post-Radiotherapy Marginal Recurrence of Malignant Lymphomas....Pages 240-240 Back Matter....Pages 241-254