Diagnosis and management of hypertrophic cardiomyopathy : sudden death prevention

Diagnosis and Management of Hypertrophic Cardiomyopathy is a unique, multi-authored compendium of information regarding the complexities of clinical and genetic diagnosis, natural history, and management of hypertrophic cardiomyopathy (HCM)—the most common and important of the genetic cardiovascular diseases—as well as related issues impacting the health of trained athletes. Edited by Dr. Barry J. Maron, a world authority on HCM, and with major contributions from all of the international experts in this field, this book provides a single comprehensive source of information concerning HCM. Recent advances in the field are discussed, including the importance of left ventricular outflow tract obstruction, the use of implantable defibrillators for the prevention of sudden death in young people, definition of the genetic basis for HCM and its role in clinical diagnosis and risk stratification, the development of more precise strategies for assessing the level of risk for sudden death among all patients with HCM, and the evolution of invasive interventions for heart failure symptoms, such as surgical management and its alternatives (alcohol septal ablation and dual-chamber pacing). Key Features: Contributions from all experts in the field, representing diverse viewpoints regarding this heterogeneous disease and related issues in athletes Information to dispel misunderstandings regarding issues associated with HCM and cardiovascular disease in athletes The only comprehensive source of information available on the topic Content: Chapter 1 Phenotypic Expression and Clinical Course of Hypertrophic Cardiomyopathy (pages 1–36): Barry J. Maron Chapter 2 Genetic Mutations that Remodel the Heart in Hypertrophic Cardiomyopathy (pages 37–66): Carolyn Y. Ho and Christine E. Seidman Chapter 3 Genetic Basis and Genotype?Phenotype Relationships in Familial Hypertrophic Cardiomyopathy (pages 67–80): Albert A. Hagege, Ketty Schwartz, Michel Desnos and Lucie Carrier Chapter 4 Historical Perspective, Mechanism, and Clinical Significance of Left Ventricular Outflow Tract Obstruction in Hypertrophic Cardiomyopathy (pages 81–94): Martin S. Maron, Iacopo Olivotto and Barry J. Maron Chapter 5 Hypertrophic Cardiomyopathy with Latent (Provocable) Obstruction: Pathophysiology and Management (pages 95–104): E. Douglas Wigle, Maria Eriksson, Paul Rakowski, David Focsaneanu, Cairrine Sloggett, Anna Woo and Harry Rakowski Chapter 6 Pathophysiology and Clinical Consequences of Atrial Fibrillation in Hypertrophic Cardiomyopathy (pages 105–120): Iacopo Olivotto, Barry J. Maron and Franco Cecchi Chapter 7 Other Modes of Disability or Death Including Stroke, and Treatment Strategies, in Hypertrophic Cardiomyopathy (pages 121–131): Franco Cecchi, Iacopo Olivotto and Barry J. Maron Chapter 8 Disturbed Vascular Control in Hypertrophic Cardiomyopathy: Mechanisms and Clinical Significance (pages 132–146): Ross Campbell, Jayne A. Morris?Thurgood and Michael P. Frenneaux Chapter 9 Clinical Significance of Diastolic Dysfunction and the Effect of Therapeutic Interventions (pages 147–157): Sandro Betocchi and Raffaella Lombardi Chapter 10 Value of Exercise Testing in Assessing Clinical State and Prognosis in Hypertrophic Cardiomyopathy (pages 158–171): Sanjay Sharma Chapter 11 Pathophysiology and Significance of Myocardial Ischemia in Hypertrophic Cardiomyopathy (pages 172–184): Rajesh Thaman, Bhavesh Sachdev and Perry M. Elliott Chapter 12 Hypertrophic Cardiomyopathy in Japan: Clinical, Morphologic and Genetic Expression (pages 185–194): Yoshinori Doi, Hiroaki Kitaoka, Nobuhiko Hitomi, Naohito Yamasaki, Yoshihisa Matsumura, Takashi Furuno and Barry J. Maron Chapter 13 Prevalence, Prevention and Treatment of Infective Endocarditis in Hypertrophic Cardiomyopathy (pages 195–199): Paolo Spirito, Marco Piccininno and Camillo Autore Chapter 14 Pharmacologic Treatment of Symptomatic Hypertrophic Cardiomyopathy (pages 200–219): Mark V. Sherrid and Ivan Barac Chapter 15 Obstructive Hypertrophic Cardiomyopathy: Results of Septal Myectomy (pages 220–235): Joseph A. Dearani and Gordon K. Danielson Chapter 16 United States Perspectives on the Role of Dual?Chamber Pacing in Patients With Hypertrophic Cardiomyopathy (pages 236–245): Paul Sorajja, Steve R. Ommen and Rick A. Nishimura Chapter 17 Dual?Chamber Pacing for Hypertrophic Obstructive Cardiomyopathy (pages 246–258): Xavier Jeanrenaud and Lukas Kappenberger Chapter 18 Alcohol Septal Ablation (pages 259–278): Hubert Seggewiss, Angelos Rigopoulos, Lothar Faber and Peer Ziemssen Chapter 19 Alcohol Septal Ablation in the Treatment of Hypertrophic Obstructive Cardiomyopathy: A Seven?Year Experience (pages 279–296): Horst Kuhn, Thorsten Lawrenz, Frank Lieder, Frank H. Gietzen, Ludger Obergassel, Claudia Strunk?Muller, Berit Stolle and Christian H. Leuner Chapter 20 Role of Septal Ablation in a Surgical Center (pages 297–306): Harry M. Lever Chapter 21 Molecular and Clinical Tools for Sudden Death Risk Assessment in Hypertrophic Cardiomyopathy (pages 307–318): Asifa Quraishi, Mohammad S. Hamid and William J. Mckenna Chapter 22 Risk Stratification for Sudden Death in Hypertrophic Cardiomyopathy: Extreme Left Ventricular Hyptertrophy as a New Indicator of Risk (pages 319–326): Paolo Spirito and Barry J. Maron Chapter 23 Implantable Defibrillator for Prevention of Sudden Death in Hypertrophic Cardiomyopathy (pages 327–344): Barry J. Maron, Win?Kuang Shen and Paolo Spirito Chapter 24 Hypertrophic Cardiomyopathy and Other Causes of Sudden Death in the Trained Athlete: An Electrophysiologist Perspective on the Management of Benign and not so Benign Arrhythmias (pages 345–366): N. A. Mark Estes, Paul J. Wang, Munther K. Homoud and Mark S. Link Chapter 25 The Athlete's Heart, ECG, and Differential Diagnosis with Hypertrophic Cardiomyopathy and Other Cardiomyopathies (pages 367–381): Antonio Pelliccia and Barry J. Maron Chapter 26 Importance of Congenital Coronary Artery Anomalies (pages 382–392): Cristina Basso, Domenico Corrado and Gaetano Thiene Chapter 27 Arrhythmogenic Right Ventricular Cardiomyopathy and Hypertrophic Cardiomyopathy: Identification with the Italian Preparticipation Athlete Screening Program (pages 393–403): Domenico Corrado, Cristina Basso, Maurizio Schiavon and Gaetano Thiene Chapter 28 Cardiovascular Causes of Sudden Death, Preparticipation Screening, and Criteria for Disqualification in Young Athletes (pages 404–431): Barry J. Maron Chapter 29 Sudden Death Due to Chest Blows (Commotio Cordis) (pages 432–447): Mark S. Link, N. A. Mark Estes and Barry J. Maron Chapter 30 Naturally Occurring Animal Models of Cardiovascular Disease Causing Premature Death (pages 448–472): Philip R. Fox Chapter 31 The Role of the Internet and Patient Support Groups for Those Living with Hypertrophic Cardiomyopathy (pages 473–479): Lisa Salberg Diagnosis and Management of Hypertrophic Cardiomyopathy is a unique, multi-authored compendium of information regarding the complexities of clinical and genetic diagnosis, natural history, and management of hypertrophic cardiomyopathy (HCM)—the most common and important of the genetic cardiovascular diseases—as well as related issues impacting the health of trained athletes. Edited by Dr. Barry J. Maron, a world authority on HCM, and with major contributions from all of the international experts in this field, this book provides a single comprehensive source of information concerning HCM. Recent advances in the field are discussed, including the importance of left ventricular outflow tract obstruction, the use of implantable defibrillators for the prevention of sudden death in young people, definition of the genetic basis for HCM and its role in clinical diagnosis and risk stratification, the development of more precise strategies for assessing the level of risk for sudden death among all patients with HCM, and the evolution of invasive interventions for heart failure symptoms, such as surgical management and its alternatives (alcohol septal ablation and dual-chamber pacing). Key Features: * Contributions from __all__ experts in the field, representing diverse viewpoints regarding this heterogeneous disease and related issues in athletes * Information to dispel misunderstandings regarding issues associated with HCM and cardiovascular disease in athletes * The only comprehensive source of information available on the topic Content: Chapter 1 Phenotypic Expression and Clinical Course of Hypertrophic Cardiomyopathy (pages 1–36): Barry J. MaronChapter 2 Genetic Mutations that Remodel the Heart in Hypertrophic Cardiomyopathy (pages 37–66): Carolyn Y. Ho and Christine E. SeidmanChapter 3 Genetic Basis and Genotype?Phenotype Relationships in Familial Hypertrophic Cardiomyopathy (pages 67–80): Albert A. Hagege, Ketty Schwartz, Michel Desnos and Lucie CarrierChapter 4 Historical Perspective, Mechanism, and Clinical Significance of Left Ventricular Outflow Tract Obstruction in Hypertrophic Cardiomyopathy (pages 81–94): Martin S. Maron, Iacopo Olivotto and Barry J. MaronChapter 5 Hypertrophic Cardiomyopathy with Latent (Provocable) Obstruction: Pathophysiology and Management (pages 95–104): E. Douglas Wigle, Maria Eriksson, Paul Rakowski, David Focsaneanu, Cairrine Sloggett, Anna Woo and Harry RakowskiChapter 6 Pathophysiology and Clinical Consequences of Atrial Fibrillation in Hypertrophic Cardiomyopathy (pages 105–120): Iacopo Olivotto, Barry J. Maron and Franco CecchiChapter 7 Other Modes of Disability or Death Including Stroke, and Treatment Strategies, in Hypertrophic Cardiomyopathy (pages 121–131): Franco Cecchi, Iacopo Olivotto and Barry J. MaronChapter 8 Disturbed Vascular Control in Hypertrophic Cardiomyopathy: Mechanisms and Clinical Significance (pages 132–146): Ross Campbell, Jayne A. Morris?Thurgood and Michael P. FrenneauxChapter 9 Clinical Significance of Diastolic Dysfunction and the Effect of Therapeutic Interventions (pages 147–157): Sandro Betocchi and Raffaella LombardiChapter 10 Value of Exercise Testing in Assessing Clinical State and Prognosis in Hypertrophic Cardiomyopathy (pages 158–171): Sanjay SharmaChapter 11 Pathophysiology and Significance of Myocardial Ischemia in Hypertrophic Cardiomyopathy (pages 172–184): Rajesh Thaman, Bhavesh Sachdev and Perry M. ElliottChapter 12 Hypertrophic Cardiomyopathy in Japan: Clinical, Morphologic and Genetic Expression (pages 185–194): Yoshinori Doi, Hiroaki Kitaoka, Nobuhiko Hitomi, Naohito Yamasaki, Yoshihisa Matsumura, Takashi Furuno and Barry J. MaronChapter 13 Prevalence, Prevention and Treatment of Infective Endocarditis in Hypertrophic Cardiomyopathy (pages 195–199): Paolo Spirito, Marco Piccininno and Camillo AutoreChapter 14 Pharmacologic Treatment of Symptomatic Hypertrophic Cardiomyopathy (pages 200–219): Mark V. Sherrid and Ivan BaracChapter 15 Obstructive Hypertrophic Cardiomyopathy: Results of Septal Myectomy (pages 220–235): Joseph A. Dearani and Gordon K. DanielsonChapter 16 United States Perspectives on the Role of Dual?Chamber Pacing in Patients With Hypertrophic Cardiomyopathy (pages 236–245): Paul Sorajja, Steve R. Ommen and Rick A. NishimuraChapter 17 Dual?Chamber Pacing for Hypertrophic Obstructive Cardiomyopathy (pages 246–258): Xavier Jeanrenaud and Lukas KappenbergerChapter 18 Alcohol Septal Ablation (pages 259–278): Hubert Seggewiss, Angelos Rigopoulos, Lothar Faber and Peer ZiemssenChapter 19 Alcohol Septal Ablation in the Treatment of Hypertrophic Obstructive Cardiomyopathy: A Seven?Year Experience (pages 279–296): Horst Kuhn, Thorsten Lawrenz, Frank Lieder, Frank H. Gietzen, Ludger Obergassel, Claudia Strunk?Muller, Berit Stolle and Christian H. LeunerChapter 20 Role of Septal Ablation in a Surgical Center (pages 297–306): Harry M. LeverChapter 21 Molecular and Clinical Tools for Sudden Death Risk Assessment in Hypertrophic Cardiomyopathy (pages 307–318): Asifa Quraishi, Mohammad S. Hamid and William J. MckennaChapter 22 Risk Stratification for Sudden Death in Hypertrophic Cardiomyopathy: Extreme Left Ventricular Hyptertrophy as a New Indicator of Risk (pages 319–326): Paolo Spirito and Barry J. MaronChapter 23 Implantable Defibrillator for Prevention of Sudden Death in Hypertrophic Cardiomyopathy (pages 327–344): Barry J. Maron, Win?Kuang Shen and Paolo SpiritoChapter 24 Hypertrophic Cardiomyopathy and Other Causes of Sudden Death in the Trained Athlete: An Electrophysiologist Perspective on the Management of Benign and not so Benign Arrhythmias (pages 345–366): N. A. Mark Estes, Paul J. Wang, Munther K. Homoud and Mark S. LinkChapter 25 The Athlete's Heart, ECG, and Differential Diagnosis with Hypertrophic Cardiomyopathy and Other Cardiomyopathies (pages 367–381): Antonio Pelliccia and Barry J. MaronChapter 26 Importance of Congenital Coronary Artery Anomalies (pages 382–392): Cristina Basso, Domenico Corrado and Gaetano ThieneChapter 27 Arrhythmogenic Right Ventricular Cardiomyopathy and Hypertrophic Cardiomyopathy: Identification with the Italian Preparticipation Athlete Screening Program (pages 393–403): Domenico Corrado, Cristina Basso, Maurizio Schiavon and Gaetano ThieneChapter 28 Cardiovascular Causes of Sudden Death, Preparticipation Screening, and Criteria for Disqualification in Young Athletes (pages 404–431): Barry J. MaronChapter 29 Sudden Death Due to Chest Blows (Commotio Cordis) (pages 432–447): Mark S. Link, N. A. Mark Estes and Barry J. MaronChapter 30 Naturally Occurring Animal Models of Cardiovascular Disease Causing Premature Death (pages 448–472): Philip R. FoxChapter 31 The Role of the Internet and Patient Support Groups for Those Living with Hypertrophic Cardiomyopathy (pages 473–479): Lisa Salberg

Diagnosis and Management of Hypertrophic Cardiomyopathy is a unique, multi-authored compendium of information regarding the complexities of clinical and genetic diagnosis, natural history, and management of hypertrophic cardiomyopathy (HCM)—the most common and important of the genetic cardiovascular diseases—as well as related issues impacting the health of trained athletes.

Edited by Dr. Barry J. Maron, a world authority on HCM, and with major contributions from all of the international experts in this field, this book provides a single comprehensive source of information concerning HCM. Recent advances in the field are discussed, including the importance of left ventricular outflow tract obstruction, the use of implantable defibrillators for the prevention of sudden death in young people, definition of the genetic basis for HCM and its role in clinical diagnosis and risk stratification, the development of more precise strategies for assessing the level of risk for sudden death among all patients with HCM, and the evolution of invasive interventions for heart failure symptoms, such as surgical management and its alternatives (alcohol septal ablation and dual-chamber pacing).

Key Features:

• Contributions from all experts in the field, representing diverse viewpoints regarding this heterogeneous disease and related issues in athletes


• Information to dispel misunderstandings regarding issues associated with HCM and cardiovascular disease in athletes

• The only comprehensive source of information available on the topic

Diagnosis and Management of Hypertrophic Cardiomyopathy is a unique, multi-authored compendium of information regarding the complexities of clinical and genetic diagnosis, natural history, and management of hypertrophic cardiomyopathy (HCM)—the most common and important of the genetic cardiovascular diseases—as well as related issues impacting the health of trained athletes.

Edited by Dr. Barry J. Maron, a world authority on HCM, and with major contributions from all of the international experts in this field, this book provides a single comprehensive source of information concerning HCM. Recent advances in the field are discussed, including the importance of left ventricular outflow tract obstruction, the use of implantable defibrillators for the prevention of sudden death in young people, definition of the genetic basis for HCM and its role in clinical diagnosis and risk stratification, the development of more precise strategies for assessing the level of risk for sudden death among all patients with HCM, and the evolution of invasive interventions for heart failure symptoms, such as surgical management and its alternatives (alcohol septal ablation and dual-chamber pacing).

Key Features:

• Contributions from all experts in the field, representing diverse viewpoints regarding this heterogeneous disease and related issues in athletes
• Information to dispel misunderstandings regarding issues associated with HCM and cardiovascular disease in athletes

• The only comprehensive source of information available on the topic

Presents a compendium of information regarding the complexities of clinical and genetic diagnosis, natural history, and management of hypertrophic cardiomyopathy (HCM) as well as related issues impacting the health of trained athletes. This book provides a single comprehensive source of information concerning HCM.