Diagnosis and Management in Dementia : The Neuroscience of Dementia, Volume 1

Diagnosis and Management in Dementia: The Neuroscience of Dementia, Volume 1 consolidates different fields of dementia into a single book, covering a range of subjects, including Alzheimer’s disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, molecular biology, and more. With an impact on millions globally, and billions of research dollars being invested in dementia research, this book will stimulate research in the area and inform researchers. Key Features Offers comprehensive coverage of a broad range of topics related to dementia Serves as a foundational collection for neuroscientists and neurologists on the biology of dementia and brain dysfunction Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding Provides unique sections on specific subareas, intellectual components, and knowledge-based niches that will help readers navigate key areas for research and further clinical recommendations Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations Serves as a "one-stop" source for everything you need to know about dementia Readership Neuroscientists/neurologists, psychologists, health scientists, public health workers, research scientists, pharmacologists, and physicians. Graduate/postgraduate students, lecturers, and professors 53 - Person-centered communication among formal caregivers of persons with dementia......Page 2 Dedication......Page 4 Contributors......Page 5 Foreword......Page 15 Introduction......Page 19 Consequences of communication impairment on persons with dementia......Page 21 Person-centered communication in dementia care......Page 22 Methods for measuring person-centered communication......Page 24 Conclusion......Page 25 Summary points......Page 26 Theoretical frameworks that support person-centered approaches to care......Page 27 References......Page 28 Epidemiology and risk factors......Page 33 Cognitive assessment......Page 38 Language-based strategies that support person-centered care......Page 39 Reduction of elderspeak......Page 40 Management and treatment options......Page 41 Emotional tone......Page 44 White matter changes......Page 52 Classification and pathogenesis of small vessel disease......Page 55 Implications for clinical practice......Page 60 Key facts of cognitive interventions......Page 61 Genetics underlying the link between frontotemporal dementias and motor neuron disease......Page 66 tDCS for late-life depression......Page 70 Final considerations......Page 82 Glucocorticoid excess......Page 92 Neuroimaging in patients with type 2 diabetes mellitus......Page 94 Other oral hypoglycemics......Page 99 Effects of tDCS on Aβ-associated dysfunction......Page 100 List of abbreviations......Page 108 Ginkgo biloba......Page 111 Resveratrol......Page 113 Phytooestrogens......Page 114 Gait as a predictor of dementia......Page 115 Dementia with lewy bodies......Page 116 Corticobasal degeneration......Page 117 List of abbreviations......Page 123 Vascular dementia......Page 125 The physiology of hypertension-related brain changes......Page 128 Cerebral perfusion and autoregulation......Page 129 Antihypertensive clinical trials for improving cognition......Page 130 Summary points......Page 134 Conclusion......Page 152 Key facts of cognition......Page 153 List of abbreviations......Page 159 Clinical symptoms of frontotemporal dementia......Page 161 Semantic dementia......Page 162 Granulin precursor gene......Page 166 Chromosome 9 open reading frame 72 gene......Page 167 Chromatin-modifying protein 2B gene......Page 168 Sequestosome 1......Page 169 tDCS for mild cognitive impairment and Alzheimer's disease......Page 171 Vagus nerve stimulation......Page 172 Conclusions......Page 173 Why are the risk factors of dementia important?......Page 178 Environment-wide mapping of risk factors......Page 179 Acknowledgments......Page 190 Key facts on the function of lipids in the brain......Page 209 Synaptic plasticity and long-term potentiation......Page 222 References......Page 228 Alzheimer disease......Page 233 TAU-related biomarkers......Page 235 Vascular cognitive impairment......Page 238 CSF neurofilament......Page 239 Dementia with lewy bodies......Page 241 Introduction......Page 245 Conclusion......Page 257 References......Page 258 List of abbreviations......Page 261 Diacylglycerols and immune responses......Page 263 List of abbreviations......Page 269 Summary points......Page 282 References......Page 283 Blood BDNF in Alzheimer’s disease: possible reasons for literature inconsistency......Page 288 Key facts of brain-derived neurotrophic factor and Alzheimer's disease......Page 297 References......Page 298 Mini-dictionary of terms......Page 303 Positron emission tomography imaging procedure......Page 307 [18F]-Labeled positron emission tomography data analysis......Page 309 Centiloid standardization method......Page 312 List of abbreviations......Page 332 Alzheimer's disease......Page 338 Progressive supranuclear palsy......Page 343 List of abbreviations......Page 349 Current limitations of retinal imaging......Page 359 References......Page 379 List of abbreviations......Page 382 Summary points......Page 393 List of abbreviations......Page 397 Summary points......Page 410 List of abbreviations......Page 413 Cognitive symptoms......Page 415 List of abbreviations......Page 430 References......Page 438 Performance-based scales......Page 445 The number of activities varies across stages of cognitive decline......Page 447 Subtle decrease in the quality of performance......Page 448 References......Page 451 Mini-dictionary of terms......Page 456 Introduction......Page 475 Choline alphoscerate......Page 481 List of abbreviations......Page 492 Key facts of Alzheimer's treatment......Page 504 Diversity between experimental findings and the clinic of dementia......Page 543 Key facts......Page 551 List of abbreviations......Page 554 Antineuroinflammatory activity of retinoids......Page 559 List of abbreviations......Page 580 Treatment of dysphagia in Parkinson's disease......Page 586 Conclusion......Page 589 References......Page 590 Astrocytes: brief history......Page 596 Human astrocytes......Page 597 Astrocyte-derived exosomes......Page 598 List of abbreviations......Page 625 Cholinergic impairment in Alzheimer's disease......Page 626 Donepezilo......Page 629 Centella asiatica (L)......Page 633 List of abbreviations......Page 640 Hexadecyl-alkylated cellulose particles effectively removed amyloid-β from human blood......Page 643 Hemodialyzers remove blood amyloid-β in hemodialysis sessions......Page 644 Other potential methods for use in extracorporeal blood amyloid-β removal systems......Page 646 Influxes of amyloid-β into the blood may come from the brain......Page 647 Rat studies demonstrate the influx of amyloid-β from the brain into the blood during blood amyloid-β removal......Page 648 Conclusion: pros and cons of extracorporeal blood amyloid-β removal systems......Page 651 List of abbreviations......Page 656 Discharge planning......Page 664 List of abbreviations......Page 672 Environmental enrichment as an intervention for Alzheimer's disease......Page 673 References......Page 681 Conclusions......Page 696 Summary points......Page 697 Introduction......Page 702 Pain and neuropsychiatric symptoms......Page 703 Rational basis for complementary use of bergamot in dementia......Page 708 Key facts of aromatherapy......Page 709 Dance from an evolutionary perspective......Page 716 List of abbreviations......Page 733 Effects of electroconvulsive therapy on amyloid-β metabolism......Page 752 Effects of rTMS on cognitive function......Page 754 Deep brain stimulation......Page 757 Key facts of depression in association with dementia......Page 758 Introduction......Page 780 List of abbreviations......Page 797 Summary points......Page 809 Preventative and therapeutic considerations......Page 818 References......Page 824 List of abbreviations......Page 829 Preserving personhood using person-centered care......Page 831 Key facts related to dementia caregiving......Page 839 A......Page 843 B......Page 846 C......Page 848 D......Page 851 E......Page 853 F......Page 854 G......Page 855 H......Page 856 I......Page 857 L......Page 858 M......Page 859 N......Page 861 P......Page 863 R......Page 866 S......Page 867 T......Page 868 U......Page 869 Y......Page 870 Diagnosis and Management in Dementia: The Neuroscience of Dementia, Volume 1 consolidates different fields of dementia into a single book, covering a range of subjects, including Alzheimer’s disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, molecular biology, and more. With an impact on millions globally, and billions of research dollars being invested in dementia research, this book will stimulate research in the area and inform researchers.

• Offers comprehensive coverage of a broad range of topics related to dementia
• Serves as a foundational collection for neuroscientists and neurologists on the biology of dementia and brain dysfunction
• Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding
• Provides unique sections on specific subareas, intellectual components, and knowledge-based niches that will help readers navigate key areas for research and further clinical recommendations
• Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations
• Serves as a "one-stop" source for everything you need to know about dementia