Diabetes and Cardiovascular Disease (Contemporary Cardiology (Hardcover))

With over ten million diagnosed patients and another five million undiagnosed, diabetes mellitus and its complications-cardiovascular disease, nephropathy, neuropathy, and retinopathy-is a major public health problem that will assume epidemic proportions as the population grows older. In Diabetes and Cardiovascular Disease, Michael T. Johnstone, md, and Aristidis Veves, md, dsc, have assembled a panel of seasoned clinicians and expert scientists to comprehensively review both the clinical and scientific aspects of diabetic cardiovascular disease. The contributors thoroughly discuss the mechanisms and risk factors of diabetes in relation to hypertension, dyslipidemia, thrombosis, atherosclerosis, coronary artery disease, and congestive heart failure. Their review includes a full examination of the epidemiology, mechanisms, methods of assessment, and treatment of the disease at the macrovascular level, and a discussion of its microvascular effects, including retinopathy, nephropathy, neuropathy, and compromised microcirculation in the diabetic foot. Each chapter covers its topics in great detail and is accompanied by extensive references. Comprehensive and up-to-date, Diabetes and Cardiovascular Disease offers not only practicing physicians the day-to-day practical knowledge needed to treat patients effectively, but also clinical scientists a deeper understanding for developing novel therapies for this devastating illness. I: Pathophysiology -- The Metabolic Syndrome And Vascular Disease / A.j. Anwar, A.h. Barnett, And S. Kumar -- Effects Of Insulin On The Vascular System / H.o. Steinberg -- Effect Of Diabetes On Endothelial Function / K. Naruse And G.l. King -- Vascular Abnormalities In The Prediabetic State / A.e. Caballero ... [et Al.] -- Diabetes And Advanced Glycation End Products / H. Vlassara -- The Renin-angiotensin System / E.p. Feener -- Diabetes And Hypertension / J.r. Sowers -- Diabetes And Dyslipidemia / H.n. Ginsberg And C. Tuck -- Diabetes And Thrombosis / D.j. Schneider And B.e. Sobel -- Diabetes And Atherosclerosis / M.f. Lopes-virella -- Animal Models Of Diabetes And Atherosclerosis / P.d. Reaven And W. Palinski -- Nitric Oxide And Its Role In Diabetes Mellitus / M.t. Johnstone And T.a. Caulfield -- Plasminogen Activator Inhibitor-1 And Vascular Disease In Diabetes Mellitus / D.e. Vaughan -- Ii: The Heart -- Coronary Artery Disease In Diabetes / D. Aronson And M.t. Johnstone -- Heart Failure In Diabetic Patients / L.h. Young ... [et Al.] -- Preoperative Assessment And Perioperative Management Of The Surgical Patient With Diabetes Mellitus / T. Laddis And M.c. Cohen -- Iii: Peripheral Vascular System -- Epidemiology Of Peripheral Vascular Disease / E.j. Boyko, N.l. Smith, And J.h. Ahroni -- Diabetes And Arterial Stiffness / I.b. Wilkinson ... [et Al.] -- Methods For Assessing Large Vessel Pathophysiology / R. Saouaf -- Peripheral Vascular Disease In Patients With Diabetes Mellitus / A.d. Hamdan ... [et Al.] -- Iv: Microcirculation -- Diabetic Retinopathy / L.p. Aiello And J. Cavallerano -- Diabetes And Nephropathy / B. Roshan And R.j. Solomon -- Vascular Changes And Diabetic Neuropathy / R.a. Malik, S. Tesfaye, And J.d. Ward -- Microcirculation Of The Diabetic Foot / O. Hamdy, K. Abuelenin, And A. Veves. Edited By Michael T. Johnstone And Aristidis Veves. Includes Bibliographical References And Index. Front Matter....Pages i-xiii Front Matter....Pages 1-1 The Metabolic Syndrome and Vascular Disease....Pages 3-22 Effects of Insulin on the Vascular System....Pages 23-43 Effect of Diabetes on Endothelial Function....Pages 45-64 Vascular Abnormalities in the Prediabetic State....Pages 65-80 Diabetes and Advanced Glycation End Products....Pages 81-102 The Renin-Angiotensin System in Diabetic Cardiovascular Complications....Pages 103-121 Diabetes and Hypertension....Pages 123-129 Diabetes and Dyslipidemia....Pages 131-147 Diabetes and Thrombosis....Pages 149-168 Diabetes and Atherosclerosis....Pages 169-194 Animal Models of Diabetes and Atherosclerosis....Pages 195-212 Nitric Oxide and Its Role in Diabetes Mellitus....Pages 213-236 Plasminogen Activator Inhibitor-1 and Vascular Disease in Diabetes Mellitus....Pages 237-243 Front Matter....Pages 245-245 Coronary Artery Disease in Diabetes....Pages 247-279 Heart Failure in Diabetic Patients....Pages 281-297 Preoperative Assessment and Perioperative Management of the Surgical Patient with Diabetes Mellitus....Pages 299-326 Front Matter....Pages 327-327 Epidemiology of Peripheral Vascular Disease....Pages 329-342 Diabetes and Arterial Stiffness....Pages 343-360 Methods of Assessing Large Vessel Pathophysiology....Pages 361-374 Peripheral Vascular Disease in Patients with Diabetes Mellitus....Pages 375-382 Front Matter....Pages 383-383 Diabetic Retinopathy....Pages 385-398 Diabetes and Nephropathy....Pages 399-410 Vascular Changes and Diabetic Neuropathy....Pages 411-430 Microcirculation of the Diabetic Foot....Pages 431-446 Back Matter....Pages 447-458 Michael T. Johnstone, MD, and Aristidis Veves, MD, DSc, have assembled a panel of seasoned clinicians and expert scientists to comprehensively review both the clinical and scientific aspects of diabetic cardiovascular disease. The contributors thoroughly discuss the mechanisms and risk factors of diabetes in relation to hypertension, dyslipidemia, thrombosis, atherosclerosis, coronary artery disease, and congestive heart failure. Their review includes a full examination of the epidemiology, mechanisms, methods of assessment, and treatment of the disease at the macrovascular level, and a discussion of the microvascular effects, including retinopathy, nephropathy, neuropathy, and compromised microcirculation in the diabetic foot. Epidemiological studies show that 65 per cent of patients with diabetes mellitus die from a cardiovascular disease. This book comprehensively reviews both the basic and clinical aspects of diabetic vascular disease for the practicing clinician. There is now a considerable body of epidemiologic evidence to support the existence of a metabolic syndrome, perhaps the most compelling being that provided by the San Antonio Heart study (4).