DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology (Cancer Principles and Practice of Oncology)

Now updated online for the life of the edition, DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology, 11th Edition keeps you up to date in this fast-changing field. Every quarter, your eBook will be updated with late-breaking developments in oncology, including new drugs, clinical trials, and more. Approved by the God of Education. This unique, continually updated reference remains the gold standard reference in the field with: A focus on immunotherapy throughout and new chapters on precision oncology and the microbiome. Guidance on managing every type of cancer, while incorporating recent treatment advances. The most effective strategies for managing every type of cancer by stage of presentation. Balanced, multidisciplinary advice from a surgeon, a medical oncologist, and a radiation oncologist. Important related topics such as cancer screening and prevention, palliative care, supportive oncology, and quality of life issues. Enhance Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech. 1. Cover......Page 2 2. Title Page......Page 3 3. Editors......Page 4 4. Copyright......Page 7 5. Contributing Authors......Page 8 6. PREFACE......Page 53 7. ACKNOWLEDGMENT......Page 54 8. CONTENTS......Page 55 9. Part I: Molecular Biology of Cancer......Page 90 10. 1 The Cancer Genome......Page 91 11. 2 Molecular Methods in Cancer......Page 128 12. 3 Hallmarks of Cancer: An Organizing Principle for Cancer Medicine......Page 159 13. 4 Microbiome and Cancer......Page 197 14. 5 Cancer Susceptibility Syndromes......Page 216 15. Part II: Etiology and Epidemiology of Cancer......Page 236 16. Section 1 Etiology of Cancer......Page 237 17. 6 Tobacco......Page 238 18. 7 Oncogenic Viruses......Page 252 19. 8 Inflammation......Page 277 20. 9 Chemical Factors......Page 288 21. 10 Physical Factors......Page 297 22. 11 Dietary Factors......Page 311 23. 12 Obesity and Physical Activity......Page 331 24. Section 2 Epidemiology of Cancer......Page 342 25. 13 Epidemiologic Methods......Page 343 26. 14 Global Cancer Incidence and Mortality......Page 357 27. Part III: Cancer Therapeutics......Page 393 28. 15 Precision Medicine in Oncology......Page 394 29. 16 Essentials of Radiation Therapy......Page 411 30. 17 Cancer Immunotherapy......Page 456 31. 18 Pharmacokinetics and Pharmacodynamics of Anticancer Drugs......Page 478 32. 19 Pharmacogenomics......Page 492 33. 20 Alkylating Agents......Page 503 34. 21 Platinum Analogs......Page 520 35. 22 Antimetabolites......Page 535 36. 23 Topoisomerase-Interacting Agents......Page 551 37. 24 Antimicrotubule Agents......Page 571 38. 25 Kinase Inhibitors as Anticancer Drugs......Page 586 39. 26 Histone Deacetylase Inhibitors and Demethylating Agents......Page 610 40. 27 Proteasome Inhibitors......Page 624 41. 28 Poly(ADP-Ribose) Polymerase Inhibitors for Tumors with Defects in DNA Repair......Page 643 42. 29 Miscellaneous Chemotherapeutic Agents......Page 651 43. 30 Hormonal Agents......Page 667 44. 31 Monoclonal Antibodies......Page 686 45. 32 Immunotherapy Agents......Page 705 46. Part IV: Cancer Prevention and Screening......Page 732 47. 33 Tobacco Use and the Cancer Patient......Page 733 48. 34 Role of Surgery in Cancer Prevention......Page 755 49. 35 Cancer Risk–Reducing Agents......Page 785 50. 36 Prophylactic Cancer Vaccines......Page 831 51. 37 Cancer Screening......Page 848 52. 38 Genetic Counseling......Page 878 53. Part V: Practice of Oncology......Page 902 54. 39 Design and Analysis of Clinical Trials......Page 903 55. 40 Assessment of Clinical Response......Page 928 56. 41 Vascular Access......Page 947 57. 42 Endoscopic and Robotic Surgery......Page 959 58. 43 Tumor Biomarkers......Page 973 59. Section 1 Cancer of the Head and Neck......Page 986 60. 44 The Molecular Biology of Head and Neck Cancers......Page 987 61. 45 Cancer of the Head and Neck......Page 999 62. Differential Diagnosis and Staging......Page 1045 63. 46 Rehabilitation After Treatment of Head and Neck Cancer......Page 1098 64. Section 2 Cancer of the Thoracic Cavity......Page 1114 65. 47 The Molecular Biology of Lung Cancer......Page 1115 66. 48 Non–small-cell Lung Cancer......Page 1135 67. Stage IV (M1)......Page 1186 68. 49 Small Cell and Neuroendocrine Tumors of the Lung......Page 1223 69. 50 Neoplasms of the Mediastinum......Page 1274 70. Section 3 Cancers of the Gastrointestinal Tract......Page 1296 71. 51 Molecular Biology of the Esophagus and Stomach......Page 1297 72. 52 Cancer of the Esophagus......Page 1307 73. Treatment of Localized Disease (.T2, Nany, M0)......Page 1352 74. 53 Cancer of the Stomach......Page 1386 75. Gastric Cancer in the Elderly......Page 1431 76. 54 The Molecular Biology of Pancreas Cancer......Page 1447 77. 55 Cancer of the Pancreas......Page 1460 78. Conclusion......Page 1500 79. 56 Molecular Biology of Liver Cancer......Page 1515 80. 57 Cancer of the Liver......Page 1528 81. 58 Cancer of the Biliary Tree......Page 1564 82. 59 Small Bowel Cancer......Page 1595 83. 60 Gastrointestinal Stromal Tumor......Page 1614 84. 61 Molecular Biology of Colorectal Cancer......Page 1634 85. 62 Cancer of the Colon......Page 1652 86. Oxaliplatin......Page 1704 87. 63 Cancer of the Rectum......Page 1742 88. 64 Cancer of the Anal Region......Page 1787 89. 65 Molecular Biology of Kidney Cancer......Page 1816 90. Section 4 Cancers of the Genitourinary System......Page 1826 91. 66 Cancer of the Kidney......Page 1827 92. 67 Molecular Biology of Bladder Cancer......Page 1864 93. 68 Cancer of the Bladder, Ureter, and Renal Pelvis......Page 1878 94. 69 The Molecular Biology of Prostate Cancer......Page 1924 95. 70 Cancer of the Prostate......Page 1942 96. Radiotherapy for Localized Prostate Cancer......Page 1978 97. 71 Cancer of the Urethra and Penis......Page 2027 98. 72 Cancer of the Testis......Page 2042 99. Section 5 Gynecologic Cancers......Page 2074 100. 73 Molecular Biology of Gynecologic Cancers......Page 2075 101. 74 Cancer of the Cervix, Vagina, and Vulva......Page 2090 102. Treatment of Metastatic Disease......Page 2145 103. 75 Cancer of the Uterine Body......Page 2159 104. 76 Gestational Trophoblastic Neoplasia......Page 2187 105. 77 Ovarian Cancer......Page 2196 106. Section 6 Cancer of the Breast......Page 2242 107. 78 Molecular Biology of Breast Cancer......Page 2243 108. 79 Malignant Tumors of the Breast......Page 2261 109. Mastectomy......Page 2296 110. Section 7 Cancer of the Endocrine System......Page 2341 111. 80 Molecular Biology of Endocrine Tumors......Page 2342 112. 81 Thyroid Tumors......Page 2358 113. 82 Parathyroid Tumors......Page 2378 114. 83 Adrenal Tumors......Page 2388 115. 84 Pancreatic Neuroendocrine Tumors......Page 2403 116. 85 Carcinoid Tumors and the Carcinoid Syndrome......Page 2429 117. 86 Multiple Endocrine Neoplasia......Page 2446 118. Section 8 Sarcomas of Soft Tissue and Bone......Page 2458 119. 87 Molecular Biology of Sarcomas......Page 2459 120. 88 Soft Tissue Sarcoma......Page 2488 121. Serious Complications of Primary Treatment......Page 2537 122. 89 Sarcomas of Bone......Page 2573 123. Section 9 Cancers of the Skin......Page 2613 124. 90 Cancer of the Skin......Page 2614 125. 91 Molecular Biology of Cutaneous Melanoma......Page 2659 126. 92 Cutaneous Melanoma......Page 2674 127. Treatment of Unresectable Metastatic (Stage IV) Melanoma......Page 2729 128. Section 10 Neoplasms of the Central Nervous System......Page 2758 129. 93 Molecular Biology of Central Nervous System Tumors......Page 2759 130. 94 Neoplasms of the Central Nervous System......Page 2770 131. Chemotherapy......Page 2814 132. Section 11 Cancers in Adolescents and Young Adults......Page 2853 133. 95 Adolescents and Young Adults with Cancer......Page 2854 134. 96 Molecular Biology of Lymphoma......Page 2879 135. Section 12 Lymphomas in Adults......Page 2908 136. 97 Hodgkin Lymphoma......Page 2909 137. 98 Non-Hodgkin Lymphoma......Page 2948 138. HIV-associated Non-Hodgkin Lymphoma......Page 2995 139. 99 Cutaneous Lymphomas......Page 3012 140. 100 Primary Central Nervous System Lymphoma......Page 3035 141. Section 13 Leukemias and Plasma Cell Tumors......Page 3047 142. 101 Molecular Biology of Acute Leukemias......Page 3048 143. 102 Management of Acute Leukemias......Page 3070 144. 103 Molecular Biology of Chronic Leukemias......Page 3108 145. 104 Chronic Myeloid Leukemia......Page 3125 146. 105 Chronic Lymphocytic Leukemias......Page 3146 147. 106 Myelodysplastic Syndromes......Page 3176 148. 107 Plasma Cell Neoplasms......Page 3202 149. POEMS Syndrome......Page 3248 150. Section 14 Other Cancers......Page 3262 151. 108 Cancer of Unknown Primary......Page 3263 152. 109 Benign and Malignant Mesothelioma......Page 3274 153. 110 Peritoneal Metastases and Peritoneal Mesothelioma......Page 3317 154. 111 Intraocular Melanoma......Page 3335 155. Section 15 Oncologic Emergencies......Page 3353 156. 112 Superior Vena Cava Syndrome......Page 3354 157. 113 Increased Intracranial Pressure......Page 3364 158. 114 Spinal Cord Compression......Page 3374 159. 115 Metabolic Emergencies......Page 3384 160. Section 16 Treatment of Metastatic Cancer......Page 3393 161. 116 Metastatic Cancer to the Brain......Page 3394 162. 117 Metastatic Cancer to the Lung......Page 3415 163. 118 Metastatic Cancer to the Liver......Page 3434 164. 119 Metastatic Cancer to the Bone......Page 3456 165. 120 Malignant Pleural and Pericardial Effusions......Page 3479 166. 121 Malignant Ascites......Page 3493 167. 122 Paraneoplastic Syndromes......Page 3504 168. Section 17 Stem Cell Transplantation......Page 3521 169. 123 Autologous Hematopoietic Cell Transplantation......Page 3522 170. 124 Allogeneic Stem Cell Transplantation......Page 3540 171. Section 18 Management of Adverse Effects of Treatment......Page 3569 172. 125 Infections in the Cancer Patient......Page 3570 173. 126 Neutropenia and Thrombocytopenia......Page 3624 174. 127 Nausea and Vomiting......Page 3638 175. 128 Diarrhea and Constipation......Page 3653 176. 129 Oral Complications......Page 3669 177. 130 Pulmonary Toxicity......Page 3694 178. 131 Cardiac Toxicity......Page 3711 179. 132 Hair Loss and Other Hair Changes......Page 3726 180. 133 Gonadal Dysfunction......Page 3734 181. 134 Fatigue......Page 3760 182. 135 Second Cancers......Page 3772 183. 136 Neurocognitive Effects......Page 3804 184. 137 Cancer Survivorship......Page 3815 185. Part VI: Palliative and Alternative Care......Page 3828 186. Section 1 Supportive Care and Quality of Life......Page 3829 187. 138 Management of Cancer Pain......Page 3830 188. 139 Nutrition Support......Page 3868 189. 140 Sexual Problems......Page 3881 190. 141 Psychological Issues......Page 3898 191. 142 Communicating News to the Cancer Patient......Page 3914 192. 143 Specialized Care of the Terminally Ill......Page 3919 193. 144 Rehabilitation of the Cancer Patient......Page 3931 194. Section 2 Complementary, Alternative, and Integrative Therapies......Page 3966 195. 145 Complementary, Alternative, and Integrative Therapies in Cancer Care......Page 3967 196. INDEX......Page 3993 197. INDEX......Page 4037 198. INDEX......Page 4083 199. INDEX......Page 4122 200. INDEX......Page 4169 201. INDEX......Page 4217 202. INDEX......Page 4240 203. INDEX......Page 4278 204. INDEX......Page 4326 Key points: A focus on immunotherapy throughout and new chapters on precision oncology and the microbiome; Guidance on managing every type of cancer, while incorporating recent treatment advances; The most effective strategies for managing every type of cancer by stage of presentation; Balanced, multidisciplinary advice from a surgeon, a medical oncologist, and a radiation oncologist; Important related topics such as cancer screening and prevention, palliative care, supportive oncology, and quality of life issues. -- Publislher [edited By] Vincent T. Devita, Jr., Theodore S. Lawrence, Steven A. Rosenberg. Includes Bibliographical References.