Developments in Tryptophan and Serotonin Metabolism (Advances in Experimental Medicine and Biology, 527)

This volume contains the proceedings of the Tenth International Meeting of the International Study Group for Tryptophan Research (ISTR V), held at the University of Padova, Padova, Italy, from 25-29 June, 2002 under the auspices of the Ministry of Education, University and Research (MIUR) in Roma, the University of Padova, the Italian Chemical Society - Division of Pharmaceutical Chemistry, the Veneto Region and the City of Padova. The meeting was organized to cover the recent developments in the field of tryptophan research. Weare very honoured that so many speakers accepted our invitation to give plenary lectures which, with the other communications, demonstrated the high scientific value of the Meeting. The publications in this volume are subdivided into nine main chapters, and cover all the major aspects in immunology, neurobiology, psychiatry, pathology, clinics, metabolism, enzymology, pharmacology, toxicology, melatonin, exercise and analytical chemistry. The volume includes the contributions of 325 scientists from 24 countries, and the Musajo Memorial Lecture delivered by Prof. Osamu Hayaishi during the Opening Ceremony. Front Matter....Pages i-xxi Musajo memorial award lecture....Pages 1-11 Front Matter....Pages 13-13 Role Of Ido Activation In Anti-Microbial Defense in Human Native Astrocytes....Pages 15-26 Tryptophan Catabolism and T Cell Responses....Pages 27-35 Quinolinic Acid Up-Regulates Chemokine Production and Chemokine Receptor Expression in Astrocytes....Pages 37-45 Tryptophan Catabolism in Nonobese Diabetic Mice....Pages 47-54 Macrophage Activating Properties of The Tryptophan Catabolite Picolinic Acid....Pages 55-65 Regulation of Ido-Mediated Bacteriostasis In Macrophages: Role of Antibiotics And Anti-Inflammatory Agents....Pages 67-76 Tryptophan Degradation During And After Gestation....Pages 77-83 Increased mRNA Expression of Kynurenine Pathway Enzymes in Human Placentae Exposed To Bacterial Endotoxin....Pages 85-89 Expression of Indoleamine 2,3-Dioxygenase In Carcinoma of Human Endometrium And Uterine Cervix....Pages 91-95 The Mechanism of Interferon-Gamma Induced Anti Toxoplasma Gondh By Indoleamine 2,3-Dioxygenase And/Or Inducible Nitric Oxide Synthase Vary Among Tissues....Pages 97-103 Expression of The Kynurenine Pathway Enzymes in Human Microglia and Macrophages....Pages 105-112 Ido (indolamine 2,3-dioxygenase) Expression and Function in the CNS....Pages 113-118 Front Matter....Pages 119-119 Neurokynurenines (Neky) as Common Neurochemical Links of Stress and Anxiety....Pages 121-125 Studies on the Neuroprotective Action of Kynurenine Mono-Oxygenase Inhibitors in Post-Ischemic Brain Damage....Pages 127-136 3-Hydroxykynurenine and Quinolinate: Pathogenic Synergism in Early Grade Huntington’s Disease?....Pages 137-145 Accumulation of Quinolinic Acid With Neuroinflammation: Does It Mean Excitotoxicity?....Pages 147-154 Kynurenic Acid And Schizophrenia....Pages 155-165 QUINOLINIC ACID IN THE PATHOGENESIS OF ALZHEIMER’S DISEASE....Pages 167-176 Kynurenine Metabolism in Central Nervous System in Experimental Chronic Renal Failure....Pages 177-182 Front Matter....Pages 119-119 T Cell Apoptosis by Kynurenines....Pages 183-190 Neurokynurenines - Seizures or/and Anxiety in Children With Epilepsy ?....Pages 191-195 Front Matter....Pages 197-197 Enzymatic Depletion of Serotonin in Vivo and Its Consequences....Pages 199-205 Tryptophan Modulation and Cognition....Pages 207-213 Tryptophan, Serotonin and Human Social Behavior....Pages 215-224 Role Of Brain Tryptophan And Serotonin In Secondary Anorexia....Pages 225-232 Plasma Leptin, Insulin And Free Tryptophan Contribute To Cytokine-Induced Anorexia....Pages 233-239 Front Matter....Pages 241-241 Recent Advances in Physiological and Pathological Significance of tryptophan-Nad + Metabolites: lessons from insulin-producing pancreatic ß-Cells....Pages 243-252 The Endogeneous Formation of Highly Chlorinated Tetrahydro-ß-Carbolines as a Possible Causative Mechanism in Idiopathic Parkinson’s Disease....Pages 253-263 Experimental Evaluation of an Altered Tryptophan Metabolism in Fibromyalgia....Pages 265-275 Age-Related Nuclear Cataract and Indoleamine 2,3-Dioxygenase-Initiated Tryptophan Metabolism in the Human Lens....Pages 277-285 Kynurenine and Neopterin Levels in Patients with Rheumatoid Arthritis and Osteoporosis During Drug Treatment....Pages 287-295 Induction of Cytochrome P450 1a1 and 1b1 by Photooxidized Tryptophan in Transformed Human Keratinocytes....Pages 297-306 Prognostic Value of Tryptophan Load Test Followed by Serum Kynurenine Determination. It’s Comparison With Pyridoxal-5-phosphate, Kynurenine, Homocysteine and Neopterin Amounts....Pages 307-315 Effective Antiretroviral Therapy Reduces Degradation of Tryptophan in Patients with HIV-1 Infection....Pages 317-323 A Clinicobiochemical Study of Tryptophan and Other Plasma and Urinary Amino Acids in the Family With Hartnup Disease....Pages 325-335 The Influence of L - Tryptophan Peroral Load on Glomerular Filtration Rate in Chronic Glomerulonephritis and Chronic Renal Failure....Pages 337-345 Neuropeptide-Containing Cells in the Cortex and Striatum of Mice With Cerebral Malaria....Pages 347-352 Tryptophan and Quality of Life in Colorectal Cancer....Pages 353-358 Effects of Chronic Lung Inflammation on Tryptophan Metabolism in Piglets....Pages 359-362 Front Matter....Pages 241-241 Tumor-Induced Changes In Host Metabolism: A Possible Role For Free Tryptophan As A Marker Of Neoplastic Disease....Pages 363-366 Kynurenine and Neopterin in the Aqueous Humor of the Anterior Chamber of the Eye and in Serum of Cataract Patients....Pages 367-374 Mechanism of Inhibitory Effect of 3- Hydroxykynurenine on Erythropoiesis in Patients with Renal Insufficiency....Pages 375-380 The Kynurenine Pathway Enzymes in Healthy and Hyperlipidemic Rabbits....Pages 381-386 Metabolism of Tryptophan Along the Kynurenine Pathway in Alloxan Diabetic Rabbits....Pages 387-393 Levels of Purine, Kynurenine and Lipid Peroxidation Products in Patients with Inflammatory Bowel Disease....Pages 395-400 Upregulation of cytochrome p450 1a2 in chronic renal failure: does oxidized tryptophan play a role?....Pages 401-407 Kidney and Liver Kynurenine Pathway Enzymes in Chronic Renal Failure....Pages 409-414 Cerebral Cholinergic Neurotransmission in Protein and Tryptophan-Restricted Adult Rats....Pages 415-421 Front Matter....Pages 423-423 Tryptophan Pyrrole Ring Cleavage Enzymes in Placenta....Pages 425-434 Increase in Conversion of Tryptophan to Niacin in Pregnant Rats....Pages 435-441 Identification and Expression of α Cdna Encoding Human 2-Amino-3- Carboxymuconate-6-Semialdehyde Decarboxylase (Acmsd): A Key Enzyme for the Tryptophan-Niacine Pathway and Quinolinate Hypothesis....Pages 443-453 Kynurenine Pathway Enzymes in Different Species of Animals....Pages 455-463 Kynurenine Pathway Enzymes in Guinea pigs....Pages 465-471 Tryptophan Metabolism in Rabbits....Pages 473-479 Tryptophan Metabolism Along the Kynurenine Pathway in Rats....Pages 481-496 Enzyme activities Along the kynurenine pathway in mice....Pages 497-510 Tryptophan metabolism via transamination. In vitro aminotransferase assay using dinitrophenylhydrazine method....Pages 511-517 Front Matter....Pages 519-519 Exercise, Fatigue, Neurotransmission and the Influence of the Neuroendocrine Axis....Pages 521-525 The Effect of Tryptophan Deficiency in the Brain on Rat Fatigue Levels: a Rat Model of Fatigue Reduction....Pages 527-530 Front Matter....Pages 519-519 Tryptophan Metabolism was Accelerated by Exercise in Rat....Pages 531-535 Front Matter....Pages 537-537 Melatonin: Detoxification of Oxygen And Nitrogen-Based Toxic Reactants....Pages 539-548 Mitochondrial regulation by melatonin And its metabolites....Pages 549-557 Therapeutic Effect of Melatonin on Cholestatic Liver Injury in Rats with Bile Duct Ligation....Pages 559-565 Antioxidant and Cytoprotective Activity of Indole Derivatives Related to Melatonin....Pages 567-575 Strategies Leading To MT 2 Selective Melatonin Receptor Antagonists....Pages 577-585 Potassium Hexacyanoferrate(Iii)-Mediated Fluorometric Determination of Melatonin....Pages 587-592 Melatonin in Plants....Pages 593-597 Front Matter....Pages 599-599 The Enol Tautomer of Indole-3-Pyruvic Acid as A Biological Switch in Stress Responses....Pages 601-608 Recent Developments in Marine Indole Alkaloid Synthesis....Pages 609-620 Modulation of the Kynurine Pathway of Tryptophan Metabolism in Search for Neuroprotective Agents. Focus on Kynurenine-3-Hydroxylase....Pages 621-628 Tryptophan-Derived Sulfur-Containing Phytoalexins-a General Overview....Pages 629-636 Towards Enantioselective Synthesis Of Tryptophan-Derived Alkaloids....Pages 637-641 Novel Bisindole Derivatives Of Catharanthus Alkaloids With Potential Cytotoxic Properties....Pages 643-646 Antiproliferative Effect Of Indigoid Pigments Isolated From Human Urine....Pages 647-651 Nad Levels In The Rat Primary Cultured Hepatocytes Affected By Peroxisome- Proliferators....Pages 653-658 The Effects Of Phthalate Esters on the Tryptophan-Niacin Metabolism....Pages 659-664 5-ht Receptors Mediating Contraction in the Rat-Tail Artery....Pages 665-670 Dietary Linoleic Acid Suppresses Gene Expression of Rat Liver α-Amino-β-Carboxymuconate-ε-Semialdehyde Decarboxylase (ACMSD) and Increases Quinolinic Acid in Serum....Pages 671-674 Front Matter....Pages 675-675 Suitability of Tryptophan Radiation Products as Markers for the Detection of γ-Irradiated Protein Rich Food....Pages 677-685 Front Matter....Pages 675-675 Photochemical Properties of Kynurenine Pathway Metabolites and Indoleamines....Pages 687-693 HPLC of Tryptophan and Its Metabolites: as Opa Derivatives and on the Basis of Their Uv and Fluorescence Spectra, Simultaneously....Pages 695-704 Ecni GC-MS Analysis of Picolinic and Quinolinic Acids and Their Amides in Human Plasma, CSF, and Brain Tissue....Pages 705-712 Drosophila Mutants of the Kynurenine Pathway As A Model for Ageing Studies....Pages 713-722 Involvement of 5-hydroxytryptophan in Melanogenesis....Pages 723-730 Interaction of 7-Azatryptophan and ß-(1-Azulenyl)-Alanine with a Nitroxyl Radical....Pages 731-737 HPLC Profiling of Trp-related Metabolites In Humans....Pages 739-744 6-Nitrotryptophan: A Specific Reaction Product Of Tryptophan Residue In Human Cu, Zn-Sod Treated With Peroxynitrite....Pages 745-749 Bioadhesive Topical Application Of Tryptophan Derivatives....Pages 751-755 Serum Tryptophan And 5-Hydroxytryptophan At Birth And During Post-Partum Days....Pages 757-760 Back Matter....Pages 761-774 This volume contains the proceedings of the Tenth International Meeting of the International Study Group for Tryptophan Research (ISTRY), held at the University of Padova, Padova, Italy, from 25-29 June, 2002 under the auspices of the Ministry of Education, University and Research (MIUR) in Roma, the University of Padova, the Italian Chemical Society - Division of Pharmaceutical Chemistry, the Venetio Revion and the City of Padova.