Detection of Chemical, Biological, Radiological and Nuclear Agents for the Prevention of Terrorism: Mass Spectrometry and Allied Topics (NATO Science for ... Security Series A: Chemistry and Biology)

This NATO-ASI installment is designed to provide an advanced overview for doctoral and post-doctoral candidates of the state-of-the-art technologies for bio-detection. The main objective of the work aims at providing readers with the latest developments necessary to successfully understand the CBRN Agents and their associated biotechnologies. The core methods focused on are mass spectrometry (including chromatographic and electrophoretic separation) and comparisons to spectroscopic, immunological and molecular analysis of chemical, biological and nuclear agents. Front Matter....Pages i-viii Biological Agents and Bioterrorism....Pages 1-10 Immunological Defence Mechanisms Against Biological Agents....Pages 11-16 Mass Spectrometry and Tandem Mass Spectrometry: An Overview....Pages 17-31 Modern Sample Preparation Techniques for Gas Chromatography-Mass Spectrometry Analysis of Environmental Markers of Chemical Warfare Agents Use....Pages 33-67 An Overview of Matrix-Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometry and Some of Its Applications....Pages 69-81 Field Portable Mass Spectrometry....Pages 83-98 MALDI Imaging Mass Spectrometry....Pages 99-113 Bacterial Identification by Mass Spectrometry....Pages 115-131 Analysis of Bio-nanoparticles by Means of Nano ES in Combination with DMA and PDMA: Intact Viruses, Virus-Like-Particles and Vaccine Particles....Pages 133-147 Mass Spectrometric Target Analysis and Proteomics in Environmental Toxicology....Pages 149-167 Proteogenomics for the Enhanced Discovery of Bacterial Biomarkers....Pages 169-177 Laser-Based Detection of Explosives and Related Compounds....Pages 179-194 Detection of Metals and Radionuclides Using Rapid, On-site, Antibody-Based Assays....Pages 195-205 Identification of Fraudulently Modified Foods....Pages 207-222 Tandem Mass Spectrometric Analysis of Novel Antineoplastic Curcumin Analogues....Pages 223-231 Glycoconjugate Vaccines Used for Prevention from Biological Agents: Tandem Mass Spectrometric Analysis....Pages 233-274 Nano-structured Solids and Heterogeneous Catalysts for the Selective Decontamination of Chemical Warfare Agents....Pages 275-284 Strategic Missile Forces in Ukraine: Brief Survey of Past and Present Environmental Problems....Pages 285-291