Design And Evaluation Of Plasmonic/magnetic Au-mfe2o4 (m-fe/co/mn) Core-shell Nanoparticles Functionalized With Doxorubicin For Cancer Therapeutics (springer Theses)

This thesis documents the development of a multifunctional nanoparticle system to enhance the chemotherapeutic efficiency of anti-cancer drugs, and contributes to research that helps decrease the side-effects in cancer patients while simultaneously increasing their survival rates. The work begins with an introduction to nanomedicine and cancer therapy, and contains a literature review on magnetic, gold, and core-shell nanoparticles. It also covers synthesis techniques, properties, various surface modifications, and the importance of magnetic and gold nanoparticles. The author dedicates a chapter to characterization techniques, experimental setup, and cell cultivation techniques for in-vitro studies. Further chapters describe the background, characterizations, and applications of multifunctional magnetite coated gold core-shell nanoparticles, and the doping of cobalt to magnetite and manganese to magnetite nanoparticles. The important highlight of this research was the control of the size, shape, composition, and surface chemistry of nanoparticles. Front Matter ....Pages i-xl Introduction to Nanomedicine and Cancer Therapy (Ravichandran Manisekaran)....Pages 1-36 Literature Survey on Magnetic, Gold, and Core-Shell Nanoparticles (Ravichandran Manisekaran)....Pages 37-72 Characterization Techniques, Experimental Setup, and Cell Cultivation (Ravichandran Manisekaran)....Pages 73-90 Designing a Nanocargo with Fe3O4@Au: A Tri-pronged Mechanism for MR Imaging, Synaphic Drug-Delivery, and Apoptosis Induction in Cancer Cells (Ravichandran Manisekaran)....Pages 91-113 Multiple Iterative Seeding of Surface Plasmon Enhanced Cobalt-Iron Oxide Nanokernels for Cancer Theranostics (Ravichandran Manisekaran)....Pages 115-138 Nano-Flotillas MnFe2O4@Au Core-Shell Nanoparticles: An Efficient MRI Contrast Agent, Magneto-hyperthermal and Drug-Delivery Armada for Cancer (Ravichandran Manisekaran)....Pages 139-159 Concluding Remarks and Future Prospects (Ravichandran Manisekaran)....Pages 161-168