Death Receptors in Cancer Therapy (Cancer Drug Discovery and Development)

Cell death, or apoptosis, plays an important role in biological processes and disease and offers special opportunities to develop new therapies for cancer, autoimmune disease, stroke, heart attack, and Alzheimer's disease. In Death Receptors in Cancer Therapy, leading physician-scientists and basic researchers review in depth our latest understanding of the molecular events that regulate cell death, illuminating those molecules that provide targets for agonists or antagonists designed to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particlar interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands. Authoritative and up-to-date, Death Receptors in Cancer Therapy offers a timely compendium of cell death signaling pathways for those seeking either a basic understanding of apoptosis or the knowledge needed to develop new therapeutics that will activate or block death signaling in disease. Front Matter....Pages i-xi Mammalian Cell Death Pathways....Pages 1-41 Resistance to Apoptosis in Cancer Therapy....Pages 43-64 Structures of TNF Receptors and Their Interactions With Ligands....Pages 65-81 Death Receptor Signaling in Embryonic Ectodermal Development....Pages 83-92 Adaptor Proteins in Death Receptor Signaling....Pages 93-109 Caspase Activation by the Extrinsic Pathway....Pages 111-131 Death Signaling and Therapeutic Applications of TRAIL....Pages 133-148 Death Receptor Mutations....Pages 149-162 Regulation of Death Receptors....Pages 163-173 Regulation of Trail Receptor Expression in Human Melanoma....Pages 175-187 Regulation of Death Receptors by Synthetic Retinoids....Pages 189-200 Role of p53 in Regulation of Death Receptors....Pages 201-206 Proapoptotic Gene Silencing Via Methylation in Human Tumors....Pages 207-229 Regulation of Death Receptor-Induced Apoptosis by NF-κB and Interferon Signaling Pathways....Pages 231-261 TRAIL in Cancer Therapy....Pages 263-279 Expression and Regulation of Death Receptors in Multiple Myeloma and Prostate Carcinoma....Pages 281-296 Regulation of TRAIL-Induced Apoptosis by Transcriptional Factors....Pages 297-303 Sensitizing Tumor Cells by Targeting Death Receptor Signaling Inhibitors....Pages 305-321 Ceramide, Ceramidase, and FasL Gene Therapy in Prostate Cancer....Pages 323-338 Gene Therapy Targeting Receptor-Mediated Cell Death to Cancers....Pages 339-354 Combination of Chemotherapy and Death Ligands in Cancer Therapy....Pages 355-366 Back Matter....Pages 367-374 An in depth review of our latest understanding of the molecular events that regulate cell death and those molecules that provide targets for developing agonists or antagonists to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particular interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands. Leading clinicians and researchers from around the world review the full scope of current developments, research, and scientific controversy regarding the principles and applications of cardiac CT. Richly illustrated with numerous black-and-white and color images, the book discusses the interpretation of CT images of the heart in a variety of clinical, physiological, and pathological applications. The authors emphasize current state-of-the-art uses of CT, but also examine developments at the horizon. They also review the technical basis of CT image acquisition, as well as tools for image visua This is an in depth review of our latest understanding of the molecular events that regulate cell death and those molecules that provide targets for developing agonists or antagonists to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. The topics of particular interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death "Death Receptors in Cancer Therapy offers a timely compendium of cell death signaling pathways for those seeking either a basic understanding of apoptosis or the knowledge needed to develop new therapeutics that will activate or block death signaling in disease." --Résumé de l'éditeur Even after numerous reports in the early to mid-1900s of "programmed cell death" with characteristic morphological changes such as cell shrinkage and nuclear condensation and fragmentation, the importance of this process in normal cellular physiology went largely unexplored (1). "Death Receptors in Cancer Therapy offers a timely compendium of cell death signaling pathways for those seeking either a basic understanding of apoptosis or the knowledge needed to develop new therapeutics that will activate or block death signaling in disease."--BOOK JACKET Edited By Wafik S. El-deiry. Includes Bibliographical References And Index. Mode Of Access: World Wide Web.