Death Receptors and Cognate Ligands in Cancer (Results and Problems in Cell Differentiation Book 49)

Annotation Death receptors play a central role in directing apoptosis in mammalian cells. This process of active cell death is important for a number of biological processes, e.g. for the regulation of the immune system. Death receptors are cell surface receptors that transmit apoptotic signals initiated by corresponding death ligands. Many complex signaling pathways are activated and apoptosis is the final result of a complex biochemical cascade of events. Besides their role in the induction of cell death, evidence now exists that death receptors are able to activate several non-apoptotic signaling pathways which, depending on cellular context, may lead to apoptosis resistance, secretion of pro-inflammatory proteins, proliferation and invasive growth of cancer cells. This book looks at the molecular basis of death receptor signaling and the role of death receptors in cancer development The role of TNF in cancer / Harald Wajant Many checkpoints on the road to cell death: regulation of Fas-FasL interactions and Fas signaling in peripheral immune responses / Madhu Ramaswamy ... [et al.] FasL expression and reverse signaling / M. Lettau ... [et al.] Impact of TNF-R1 and CD95 internalization on apoptotic and antiapoptotic signaling / Stefan Schütze and Wulf Schneider-Brachert Ubiquitination and TNFR1 signaling / Ken-ichi Fujita and Srinivasa M. Srinivasula From biochemical principles of apoptosis induction by TRAIL to application in tumour therapy / Stefanie M. Cordier, Kerstin Papenfuss, and Henning Walczak Therapeutic targeting of TWEAK/Fn14 in cancer: exploiting the intrinsic tumor cell killing capacity of the pathway / Jennifer S. Michaelson and Linda C. Burkly APRIL in B-cell malignancies and autoimmunity / Fiona C. Kimberly, Jan Paul Medema, and Michael Hahne Autophagy in cancer and chemotherapy / Shida Yousefi and Hans-Uwe Simon Glucocorticoid-mediated apoptosis resistance of solid tumors / Ingrid Herr, Markus W. Büchler, and Jürgen Mattern Targeting death-receptors in radiation therapy / Olivier Niemöller and Claus Belka Death ligands designed to kill: development and application of targeted cancer therapeutics based on proapoptotic TNF family ligands / Jeannette Gerspach, Harald Wajant, and Klaus Pfizenmaier. 9783642030444 Death Receptors and Cognate Ligands in Cancer 1 Cover 1 Details 4 Contents 5 Introduction - Following the Death TRAIL to Hunt Down Tumor Cells: Translating Programmed Cell Death Signaling Mechanisms into Clinical Practice 7 The Role of TNF in Cancer 14 Many Checkpoints on the Road to Cell Death: Regulation of Fas–FasL Interactions and Fas Signaling in Peripheral Immune Responses 29 FasL Expression and Reverse Signalling 60 Impact of TNF-R1 and CD95 Internalization on Apoptotic and Antiapoptotic Signaling 73 Ubiquitination and TNFR1 Signaling 96 From Biochemical Principles of Apoptosis Induction by TRAIL to Application in Tumour Therapy 124 Therapeutic Targeting of TWEAK/Fn14 in Cancer: Exploiting the Intrinsic Tumor Cell Killing Capacity of the Pathway 153 APRIL in B-cell Malignancies and Autoimmunity 169 Autophagy in Cancer and Chemotherapy 191 Glucocorticoid-Mediated Apoptosis Resistance of Solid Tumors 199 Targeting Death-Receptors in Radiation Therapy 227 Death Ligands Designed to Kill: Development and Application of Targeted Cancer Therapeutics Based on Proapoptotic TNF Family Lig 248 Index 281 9783642030444 Front Matter....Pages i-xiii The Role of TNF in Cancer....Pages 1-15 Many Checkpoints on the Road to Cell Death:Regulation of Fas–FasL Interactions and Fas Signaling in Peripheral Immune Responses....Pages 17-47 FasL Expression and Reverse Signalling....Pages 49-61 Impact of TNF-R1 and CD95 Internalization on Apoptotic and Antiapoptotic Signaling....Pages 63-85 Ubiquitination and TNFR1 Signaling....Pages 87-114 From Biochemical Principles of Apoptosis Induction by TRAIL to Application in Tumour Therapy....Pages 115-143 Therapeutic Targeting of TWEAK/Fn14 in Cancer: Exploiting the Intrinsic Tumor Cell Killing Capacity of the Pathway....Pages 145-160 APRIL in B-cell Malignancies and Autoimmunity....Pages 161-182 Autophagy in Cancer and Chemotherapy....Pages 183-190 Glucocorticoid-Mediated Apoptosis Resistance of Solid Tumors....Pages 191-218 Targeting Death-Receptors in Radiation Therapy....Pages 219-239 Death Ligands Designed to Kill: Development and Application of Targeted Cancer Therapeutics Based on Proapoptotic TNF Family Ligands....Pages 241-273 Back Matter....Pages 275-280