David A Sinclair Lifespan Why We Age and Why We Dont Have To with Matthew D LaPlante 2019 ISBN 978-1501191978

**A __NEW YORK TIMES__ BESTSELLER** **“Brilliant and enthralling.”​ —The __Wall Street Journal__****A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of __Time__’s most influential people.**It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan?In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.”This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to younger, but actually younger.Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, will forever change the way we think about why we age and what we can do about it. From An Acclaimed Harvard Professor And One Of Time's Most Influential People, This Paradigm-shifting Book Shows How Almost Everything We Think We Know About Aging Is Wrong, Offers A Front-row Seat To The Amazing Global Effort To Slow, Stop, And Reverse Aging, And Calls Readers To Consider A Future Where Aging Can Be Treated. For Decades, Experts Have Believed That We Are At The Mercy Of Our Genes, And That Natural Damage To Our Genes--the Kind That Inevitably Happens As We Get Older--makes Us Become Sick And Grow Old. But What If Everything You Think You Know About Aging Is Wrong? What If Aging Is A Disease--and That Disease Is Treatable? In Lifespan, One Of The World's Foremost Experts On Aging And Genetics Reveals A Groundbreaking New Theory That Will Forever Change The Way We Think About Why We Age And What We Can Do About It. Aging Isn't Immutable; We Can Have Far More Control Over It Than We Realize. This Eye-opening And Provocative Work Takes Us To The Frontlines Of Research That Is Pushing The Boundaries On Our Perceived Scientific Limitations, Revealing Incredible Breakthroughs--many From Dr. David Sinclair's Own Lab--that Demonstrate How We Can Slow Down, Or Even Reverse, The Genetic Clock. The Key Is Activating Newly Discovered Vitality Genes--the Decedents Of An Ancient Survival Circuit That Is Both The Cause Of Aging And The Key To Reversing It. Dr. Sinclair Shares The Emerging Technologies And Simple Lifestyle Changes--such As Intermittent Fasting, Cold Exposure, And Exercising With The Right Intensity--that Have Been Shown To Help Lead To Longer Lives. Lifespan Provides A Roadmap For Taking Charge Of Our Own Health Destiny And A Bold New Vision For The Future When Humankind Is Able To Live To Be 100 Years Young-- What If Everything We've Been Taught To Believe About Aging Is Wrong? What If Aging Is A Disease-- And That Disease Is Treatable? Sinclair Believes The Key To Stopping-- Or Even Reversing-- The Genetic Clock Is Activating Newly Discovered Vitality Genes. He Provides A Roadmap For Taking Charge Of Our Own Health Destiny. -- Adapted From Jacket David A. Sinclair, Phd, Ao, With Matthew D. Laplante ; Illustrations By Catherine L. Delphia. Includes Bibliographical References (pages 315-367) And Index. "From an acclaimed Harvard professor and one of Time's most influential people, this paradigm-shifting book shows how almost everything we think we know about aging is wrong, offers a front-row seat to the amazing global effort to slow, stop, and reverse aging, and calls readers to consider a future where aging can be treated. For decades, experts have believed that we are at the mercy of our genes, and that natural damage to our genes--the kind that inevitably happens as we get older--makes us become sick and grow old. But what if everything you think you know about aging is wrong? What if aging is a disease--and that disease is treatable? In Lifespan, one of the world's foremost experts on aging and genetics reveals a groundbreaking new theory that will forever change the way we think about why we age and what we can do about it. Aging isn't immutable; we can have far more control over it than we realize. This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs--many from Dr. David Sinclair's own lab--that demonstrate how we can slow down, or even reverse, the genetic clock. The key is activating newly discovered vitality genes--the decedents of an ancient survival circuit that is both the cause of aging and the key to reversing it. Dr. Sinclair shares the emerging technologies and simple lifestyle changes--such as intermittent fasting, cold exposure, and exercising with the right intensity--that have been shown to help lead to longer lives. Lifespan provides a roadmap for taking charge of our own health destiny and a bold new vision for the future when humankind is able to live to be 100 years young"-- Provided by publisher A NEW YORK TIMES BESTSELLER "Brilliant and enthralling."​ —The Wall Street Journal A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time 's most influential people. It's a seemingly undeniable truth that aging is inevitable. But what if everything we've been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: "Aging is a disease, and that disease is treatable." This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair's own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it. A NEW YORK TIMES BESTSELLER A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time 's most influential people. It's a seemingly undeniable truth that aging is inevitable. But what if everything we've been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: "Aging is a disease, and that disease is treatable." This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs{u2014}many from Dr. David Sinclair's own lab at Harvard{u2014}that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes{u2014}such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat{u2014}that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it "A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time's most influential people. It's a seemingly undeniable truth that aging is inevitable. But what if everything we've been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he explains: "Aging is a disease, and that disease is treatable." This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs--many from Dr. David Sinclair's own lab at Harvard--that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes--such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat--that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it."--Dust jacket A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time 's most influential people. It's a seemingly undeniable truth that aging is inevitable. But what if everything we've been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: "Aging is a disease, and that disease is treatable." This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair's own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key... Dedication 9 Introduction: A Grandmother’s Prayer 11 Part I: What We Know (The Past) 23 Chapter 1. ‘Viva Primordium’ 24 Chapter 2. The Demented Pianist 47 Chapter 3. The Blind Epidemic 81 Part II: What We’re Learning (The Present) 100 Chapter 4. Longevity Now 101 Chapter 5. A Better Pill to Swallow 128 Chapter 6. Big Steps Ahead 157 Chapter 7. The Age of Innovation 183 Part III: Where We’re Going (The Future) 214 Chapter 8. The Shape of Things to Come 215 Chapter 9. A Path Forward 261 Conclusion 291 Acknowledgments 306 Sinclair Disclosure 310 The Scale of Things 311 Cast of Characters 313 Glossary 320 About the Authors 331 Notes 335 Index 387 Copyright 445 Its a seemingly undeniable truth that aging is inevitable. But what if everything weve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: Aging is a disease, and that disease is treatable. This book takes us to the frontlines of research many from Dr. David Sinclairs own lab at Harvardthat demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it.