Data Integration in the Life Sciences: 4th International Workshop, DILS 2007, Philadelphia, PA, USA, June 27-29, 2007, Proceedings (Lecture Notes in Computer Science, 4544)

Understanding the mechanisms involved in life (e. g., discovering the biological functionofasetofproteins, inferringtheevolutionofasetofspecies)isbecoming increasinglydependent onprogressmade inmathematics, computer science, and molecular engineering. For the past 30 years, new high-throughput technologies have been developed generating large amounts of data, distributed across many data sources on the Web, with a high degree of semantic heterogeneity and di?erentlevelsofquality. However, onesuchdatasetisnot, byitself, su?cientfor scienti?c discovery. Instead, it must be combined with other data and processed by bioinformatics tools for patterns, similarities, and unusual occurrences to be observed. Both data integration and data mining are thus of paramount importance in life science. DILS 2007 was the fourth in a workshop series that aims at fostering d- cussion, exchange, and innovation in research and development in the areas of data integration and data management for the life sciences. Each previous DILS workshop attracted around 100 researchers from all over the world. This year, the number of submitted papers again increased. The Program Committee - lected 19 papers out of 52 full submissions. The DILS 2007 papers cover a wide spectrum of theoretical and practical issues including scienti?c work?ows, - notation in data integration, mapping and matching techniques, and modeling of life science data. Among the papers, we distinguished 13 papers presenting research on new models, methods, or algorithms and 6 papers presenting imp- mentation of systems or experience with systems in practice. In addition to the presented papers, DILS 2007 featured two keynote talks by Kenneth H. Buetow, National Cancer Institute, and Junhyong Kim, University of Pennsylvania Front Matter....Pages - Enabling the Molecular Medicine Revolution Through Network-Centric Biomedicine....Pages 1-2 Phyl-O’Data (POD) from Tree of Life: Integration Challenges from Yellow Slimy Things to Black Crunchy Stuff....Pages 3-5 Automatically Constructing a Directory of Molecular Biology Databases....Pages 6-16 The Allen Brain Atlas: Delivering Neuroscience to the Web on a Genome Wide Scale....Pages 17-26 Toward an Integrated RNA Motif Database....Pages 27-36 B-Fabric: A Data and Application Integration Framework for Life Sciences Research....Pages 37-47 SWAMI: Integrating Biological Databases and Analysis Tools Within User Friendly Environment....Pages 48-58 $^{\textrm{\small{my}}}$ Grid and UTOPIA: An Integrated Approach to Enacting and Visualising in Silico Experiments in the Life Sciences....Pages 59-70 A High-Throughput Bioinformatics Platform for Mass Spectrometry-Based Proteomics....Pages 71-88 Bioinformatics Service Reconciliation by Heterogeneous Schema Transformation....Pages 89-104 A Formal Model of Dataflow Repositories....Pages 105-121 Project Histories: Managing Data Provenance Across Collection-Oriented Scientific Workflow Runs....Pages 122-138 Fast Approximate Duplicate Detection for 2D-NMR Spectra....Pages 139-155 Ontology – Supported Machine Learning and Decision Support in Biomedicine....Pages 156-171 Instance-Based Matching of Large Life Science Ontologies....Pages 172-187 Data Integration and Pattern-Finding in Biological Sequence with TESS’s Annotation Grammar and Extraction Language (AnGEL)....Pages 188-203 Inferring Gene Regulatory Networks from Multiple Data Sources Via a Dynamic Bayesian Network with Structural EM....Pages 204-214 Accelerating Disease Gene Identification Through Integrated SNP Data Analysis....Pages 215-230 What’s New? What’s Certain? – Scoring Search Results in the Presence of Overlapping Data Sources....Pages 231-246 Using Annotations from Controlled Vocabularies to Find Meaningful Associations....Pages 247-263 CONANN: An Online Biomedical Concept Annotator....Pages 264-279 Back Matter....Pages - This book constitutes the refereed proceedings of the 4th International Workshop on Data Integration in the Life Sciences, DILS 2007, held in Philadelphia, PA, USA in July 2007. The 19 revised full papers presented together with two keynote talks were carefully reviewed and selected from 52 submissions. The papers address all current issues in data integration and data management from the life science point of view and are organized in topical sections on new architectures and experience on using systems, managing and designing scientific workflows, mapping and matching techniques, modelling of life science data, and annotation in data integration