Cytomegalovirus: Biology And Infection (current Topics In Infectious Disease)

Although there are a number of excellent current reviews on one or another aspect of cytomegalovirus, the last comprehensive treatment of this subject was that of Krech et al. (1971a). In view of the amazing advances in the virological, epidemiologic, and clinical knowledge of cytomegaloviruses, an up-to-date book is needed. Such a work should cover many areas of expertise and a voluminous technical literature. Each area might have been reviewed and analyzed by workers more expert than myself. However, I have embarked on the entire venture alone in order to attain unity and continuity in this book, characteristics that are not easily achieved in the more popular multiauthored works. I have tried to review the literature and to provide a critical summary for each area discussed. To do this, I provide as much of the primary data of the relevant works as needed and not just the qualitative conclusions. Inevitably, the flow of the narrative may be interrupted by dry facts and figures. However, such information is essential to make this a meaningful reference work. But for those not interested in such details, I have provided at what I hope are crucial points critiques and summaries. This book is not an exhaustive review of all the literature. This is probably no longer possible or even desirable. By selection, however, one runs the risk of having missed or ignored important papers. I am keenly aware of this, and I wish to apologize for such oversight, if that is possible. Front Matter....Pages i-xvii Front Matter....Pages 1-1 History of Human Cytomegalovirus....Pages 3-7 Characteristics of Cytomegalovirus....Pages 9-32 Human Cytomegalovirus Infections in Cells and Tissues....Pages 33-46 Serologic Tests for Human Cytomegalovirus Infections....Pages 47-67 Variants of Human Cytomegalovirus....Pages 69-77 Epidemiology of Cytomegalovirus Infection in Man....Pages 79-104 Cell-Mediated Immunity to Cytomegalovirus Infection....Pages 105-118 Pathology of Cytomegalovirus Infection....Pages 119-129 Congenital and Perinatal Human Cytomegalovirus Infections....Pages 131-149 Acquired Cytomegalovirus Infection and the Mononucleosis Syndrome....Pages 151-170 Human Cytomegalovirus Infections in Immunosuppressed Patients....Pages 171-204 Treatment and Prevention of Cytomegalovirus Infections....Pages 205-213 Front Matter....Pages 215-215 Nonhuman Cytomegalovirus....Pages 217-222 Murine Cytomegalovirus....Pages 223-243 Back Matter....Pages 245-309