Cytokines in the Treatment of Infectious Diseases : Options for the Modulation of Host Defense

Only recently a new range of agents has become available that are capable of stimulating and regulating host defense systems against microorganisms. Interleukins, interferons and haematopoietic growth factors are now being produced by the biotechnology industry and are being evaluated for clinical use in this area. __Cytokines in the Treatment of Infectious Diseases__ provides a unique, up-to-date survey of this research area. The use of cytokines in a series of (groups of) infectious diseases is discussed in twelve succinct chapters, from model to clinical study, written by twenty-five expert authors from the world's key institutes in this area. The book is aimed at microbiologists, immunologists, molecular biologists, cell biologists and other scientific disciplines in the field of biotherapy. It is required reading for physicians dealing with infectious diseases who wish to keep up to date with the developments in this field. Front Matter....Pages i-iii Introduction: Cytokines in the biotherapy of infectious diseases....Pages 149-150 Cytokines in the treatment of virus infections....Pages 151-159 Interleukin-1 and related pro-inflammatory cytokines in the treatment of bacterial infections in neutropenic and non-neutropenic animals....Pages 161-167 Cytokines and the host defense against Listeria monocytogenes and Salmonella typhimurium ....Pages 169-178 Cytokines and legionellosis....Pages 179-186 The role of cytokines in mycobacterial infection....Pages 187-193 Cytokines in the treatment of fungal infections....Pages 195-210 Cytokines in malaria, pathology and protection....Pages 211-221 Cytokines in the treatment of leishmaniasis: From studies of immunopathology to patient therapy....Pages 223-235 The role of cytokines in toxoplasmosis....Pages 237-247 Cytokines in the treatment of primary immunodeficiency....Pages 249-259 Cytokines as potential vaccine adjuvants....Pages 261-269