Cytokines in the Genesis and Treatment of Cancer (Cancer Drug Discovery and Development)

__Cytokines in the Genesis and Treatment of Cancer__ provides a comprehensive picture of the dual role of host responses in promoting and inhibiting tumor progression. This volume represents an important investigation into the emerging intersection of cancer biology and cancer immunology. Divided into four sections, the volume’s first three parts focus on cytokines in the genesis of cancer. The final section describes the notable progress — both in animal models and humans — in demonstrating the use of cytokine or anticytokine therapies for the prevention and treatment of cancer. __Cytokines in the Genesis and Treatment of Cancer__ brings together an impressive array of internationally distinguished investigators who are devoted to the study of cytokines and cancer. Together, they produce an insightful, comprehensive discussion of cytokines and cancer that will serve as the perfect reference for all those working in the field. Helicobacter pylori and cytokines in the genesis of gastric cancer / Richard M. Peek, Jr HTLV-1, cytokines, and cancer / Michael Lairmore and Lee Ratner Herpesviruses, Cytokines, and Cancer / Frank J. Jenkins and Heather R. Hensler Tumor necrosis factor and cancer / Mark DeWitte ... [et al.] Transforming growth factor B and cancer / Alyssa R. Bonine-Summers, Brian K. Law, and Harold L. Moses Interleukin-1 family of cytokines and cancer / Michael T. Lotze Interleukin-4/13 and cancer / Koji Kawakami and Raj K. Puri Interleukin-6 and Castleman's disease / Norihiro Nishimoto Interleukin 10 family of cytokines / Shin-Ichiro Fujii and Michael T. Lotze Cytokines in multiple myeloma: therapeutic implications / Dharminder Chauhan, Teru Hideshima, and Kenneth C. Anderson In vivo murine cytokine models and the genesis of cancer / Todd A. Fehniger, Megan A. Cooper, Michael A. Caligiuri Experimental models of cytokines and cancer prevention / Mark J. Smyth ... [et al.] Cytokines in the tumor stroma / Michael C. Ostrowski Cytokines and tumor angiogenesis / Sharmila Roy-Chowdhury and Charles K. Brown Chemokines and receptor expression in tumor progression / Paola Allavena, Federica Marchesi, and Alberto Mantovani The biology of cancer cachexia and the role of TNF-A / Denis C. Guttridge Interleukin-2 and cancer therapy / Kim Margolin and Joseph Clark Interleukin-12 and cancer therapy / Timothy E. Bael and Jared Gollob The type I interferon system with emphasis on its role in malignancies: interferons are more than "antivirals" / Stergios J. Moschos ... [et al.] Combination cytokine therapy / Seth M. Cohen and Howard L. Kaufman Novel strategies for cytokine administration via targetting / Paul M. Sondel ... [et al.] Cytokines and cancer vaccines / Hideho Okada and Michael T. Lotze Anticytokine therapy / Miguel A. Villalona-Calero Cytokines in the supportive care of cancer / John A. Glaspy. Front Matter....Pages i-xix Front Matter....Pages 1-1 Helicobacter pylori and Cytokines in the Genesis of Gastric Cancer....Pages 3-26 HTLV-1, Cytokines,and Cancer....Pages 27-51 Herpesviruses, Cytokines, and Cancer....Pages 53-67 Front Matter....Pages 69-69 Tumor Necrosis Factor and Cancer....Pages 71-89 Transforming Growth Factor-β and Cancer....Pages 91-111 Interleukin-1 Family of Cytokines and Cancer....Pages 113-133 Interleukin-4/13 and Cancer....Pages 135-153 Interleukin-6 and Castleman’s Disease....Pages 155-163 Interleukin-10 (IL-10)....Pages 165-179 Cytokines in Multiple Myeloma....Pages 181-197 In Vivo Murine Cytokine Models and the Genesis of Cancer....Pages 199-209 Experimental Models of Cytokines and Cancer Prevention....Pages 211-230 Front Matter....Pages 231-231 Cytokines in the Tumor Stroma....Pages 233-244 Cytokines and Tumor Angiogenesis....Pages 245-266 Chemokine and Receptor Expression in Tumor Progression....Pages 267-283 The Biology of Cancer Cachexia and the Role of TNF-α....Pages 285-303 Front Matter....Pages 305-305 Interleukin-2 and Cancer Therapy....Pages 307-316 Interleukin-12 and Cancer Therapy....Pages 317-338 The Type I Interferon System With Emphasis on Its Role in Malignancies....Pages 339-372 Combination Cytokine Therapy....Pages 373-398 Front Matter....Pages 305-305 Novel Strategies for Cytokine Administration Via Targetting....Pages 399-422 Cytokines and Cancer Vaccines....Pages 423-436 Anticytokine Treatment....Pages 437-448 Cytokines in the Supportive Care of Cancer....Pages 449-469 Back Matter....Pages 471-482

Cytokines in the Genesis and Treatment of Cancer provides a comprehensive picture of the dual role of host responses in promoting and inhibiting tumor progression. This volume represents an important investigation into the emerging intersection of cancer biology and cancer immunology. Divided into four sections, the volume’s first three parts focus on cytokines in the genesis of cancer. The final section describes the notable progress — both in animal models and humans — in demonstrating the use of cytokine or anticytokine therapies for the prevention and treatment of cancer. Cytokines in the Genesis and Treatment of Cancer brings together an impressive array of internationally distinguished investigators who are devoted to the study of cytokines and cancer. Together, they produce an insightful, comprehensive discussion of cytokines and cancer that will serve as the perfect reference for all those working in the field.

This volume looks at the complex interactions between cytokines and cancer. By exploring the clearly demonstrated link between cytokines and cancer, it highlights potential treatment strategies that take advantage of utilizing cytokine and anti-cytokine therapies