Cytokines (Growth Factors & Cytokines in Health & Disease) Part A

Progress in molecular technology in recent years has caused an amazing growth of information about intercellular peptide messengers and their receptors. The number of characterized interleukins for example numbered just three six years ago and now there are at least 16. In addition, the number of described neutrophic peptides is around 30 and the number of receptors is ever increasing. Because many of these new peptide ligands and receptors were identified by'reverse genetic'techniques the understanding of their biological roles falls behind the knowledge of their molecular structures. However a new strain of functional studies has begun and animal models are developed allowing for further research into the biological roles of these messenger peptides and their receptors. Cytokines, the theme of this volume, describes a group of proteins identified primarily within the immune and hematopoietic systems. As many cytokines as possible are included along with their receptors providing the reader with a guide to an ever-changing field of scientific research. Front Cover......Page 1 Growth Factors and Cytokines in Health and Disease......Page 4 Copyright Page......Page 5 CONTENTS......Page 6 LIST OF CONTRIBUTORS......Page 10 PREFACE......Page 14 CHAPTER 1. THE TYPE I INTERFERON RECEPTOR COMPLEX......Page 16 CHAPTER 2. INTERFERON-BETA: STRUCTURE, DIFFERENTIAL ACTIONS, AND MEDICAL APPLICATIONS......Page 46 CHAPTER 3. THE MOLECULAR BASIS OF IFNγ ACTION......Page 134 CHAPTER 4. CYTOKINES: GRANULOCYTE COLONY-STIMULATING FACTOR......Page 170 CHAPTER 5. LEUKEMIA INHIBITORY FACTOR AND ITS RECEPTOR......Page 226 CHAPTER 6. TUMOR NECROSIS FACTOR......Page 282 CHAPTER 7. LYMPHOTOXIN: DEVELOPMENTS DURING THE LAST DECADE......Page 340 CHAPTER 8. IL-6, IL-11, LIF, OSM, CARDIOTROPHIN-1 AND CNTF: AN EXAMPLE OF A CYTOKINE FAMILY SHARING SIGNAL TRANSDUCTING RECEPTOR COMPONENTS......Page 390 INDEX......Page 424