Cytokines and the Brain (Volume 6) (NeuroImmune Biology, Volume 6)

This book opens a new page of neuroimmunebiology providing substantive experimental and clinical data to support current understanding in the field, and potential applications of this knowledge in the treatment of disease. The volume is a collection of complex, new data drawn from multiple areas of investigation in the field. The contents summarize current understanding on the presence and function of CNS cytokines and their receptors in a variety of central nervous system cells during health and disease. The chapters are a collection of complex, new data demonstrating the presence and synthesis of cytokines in brain cells, as well as their receptors on cell membranes in health and disease. The strength of the volume are the descriptions of the authors own investigations, together with those of others in the field pertaining to a large number of cytokines in brain function, as well as mechanisms involved in the development of CNS disorders, including multiple sclerosis and Alzheimer's disease. Also included are novel approaches to the treatment of CNS disorders based on new experimental data. The contributors to this volume are internationally known scientists and clinical researchers in their respective fields of investigation and treatment. * Opens a new page of neuroimmunebiology and provides substantive evidence for the promise of this field in the treatment of disease * Summarizes current understanding on the presence and function of CNS cytokines and their receptors in a variety of central nervous system cells during health and disease * Includes novel approaches to the treatment of CNS disorders based on new experimental data * Offers new insight into triggers for the development of autoimmune diseases in the brain and the possibilities for treatment Content: Series Editors Page ii Volume Editors Page iii Copyright page Page iv Foreword Pages ix-xiii Istvan Berczi, Andor Szentivanyi Preface Page xv Istvan Berczi Dedication Page xvii Samuel Saporta Obituary Pages xix-xxv Istvan Berczi List of Contributors Pages xxvii-xxxi The History of Neuroimmune Biology Review Article Pages 1,3-17 Istvan Berczi, Andor Szentivanyi Cytokine Receptors in the Brain Review Article Pages 19,21-38 Bruno Conti, Iustin Tabarean, Manuel Sanchez-Alavez, Christopher Davis, Sara Brownell, Margarita Behrens, Tamas Bartfai Interleukin-1 and Corticotropin-Releasing Factor Receptors in the Hypothalamic–Pituitary–Adrenal Axis Review Article Pages 39-54 Toshihiro Takao, Kozo Hashimoto, Errol B De Souza Brain Interleukin-1β Expression and Action in the Absence of Neuropathology Review Article Pages 55-77 Léa Chaskiel, Jan Pieter Konsman Interleukin-1β Signal Transduction via the Sphingomyelin Pathway in Brain Cells Review Article Pages 79-91 Elena G. Rybakina, Elena A. Korneva Blood–Brain Barrier Transport of Cytokines Review Article Pages 93-107 William A Banks Cytokines in Synaptic Function Review Article Pages 109,111-143 Tracey A Ignatowski, Robert N Spengler Interleukin-2 as a Neuroregulatory Cytokine Review Article Pages 145-165 Marco Prinz, Denise Van Rossum, Uwe-Karsten Hanisch Cytokines and Extracellular Matrix Remodeling in the Central Nervous System Review Article Pages 167-197 Marzenna Wiranowska, Anna Plaas Acidic Fibroblast Growth Factor, a Satiety Substance, with Diverse Physiological Significance Review Article Pages 199-211 Yutaka Oomura Cytokines and Sleep Review Article Pages 213-240 James M Krueger, David M Rector, Lynn Churchill Chemokines, their Receptors and Significance in Brain Function Review Article Pages 242-273 Tullio Florio, Gennaro Schettini Immune and Inflammatory Responses in the Central Nervous System: Modulation by Astrocytes Review Article Pages 275,277-288 Milena Penkowa, Juan Hidalgo, Michael Aschner Immune Response in the Brain: Glial Response and Cytokine Production Review Article Pages 289-303 Akio Suzumura Lymphocytes and Adrenergic Sympathetic Nerves: The Role of Cytokines Review Article Pages 305,307-336 Yukiko Kannan-Hayashi, Mitsuaki Moriyama, Yoichi Nakamura Cytokines in Neural Signaling to the Brain Review Article Pages 337-352 Lisa E. Goehler Interleukin-2 Gene Expression in Central Nervous System Cells after Stress and Antigen Application Review Article Pages 353-372 Elena A. Korneva, Tatiana B. Kazakova Sex Hormones and Cytokines in Central Nervous System Pathology and Repair Review Article Pages 373-390 Andrés GottfriedBlackmore, Gist F. Croft, Karen Bulloch Involvement of Brain Cytokines in Stress-induced Immunosuppression Review Article Pages 391-401 Toshihiko Katafuchi Neuroprotective Effects of Inflammation in the Nervous System Review Article Pages 403-431 Jorge Correale, Marcela Fiol, Andrés Villa Brain Response to Endotoxin Review Article Pages 433,435-454 Christopher Phelps, Li-Tsun Chen Cytokines in Demyelinating Diseases Review Article Pages 455-483 Sergey A. Ketlinskiy, Natalia M. Kalinina The Cytokines and Depression Hypothesis: An Evaluation Review Article Pages 485-506 Adrian J Dunn Clinical Relevance: Cytokines in Alzheimer’s Disease Review Article Pages 507-526 William K Summers Cytokines and Immune-Related Behaviors Review Article Pages 527,529-547 Arnaud Aubert, Julien Renault The Production and Effects of Cytokines Depend on Brain Lateralization Review Article Pages 549-563 Pierre J. Neveu Concluding Remarks Review Article Pages 565,567-570 Elena A. Korneva Subject Index Pages 571-575 I. History The history of Neuroimmune Biology: II. Cytokines and in the brain; A.Cytokines, their receptors and signal transduction in the brain; Cytokine Receptors in the Brain; Interleukin-1 and Corticotropin Releasing Factor Receptors in the Hypothalamic-Pituitary-Adrenal Axis; Brain interleukin-1́ expression and action in the absence of neuropathology; Interleukin 1́ signal transduction via the sphingomyelin pathway in brain cells; Blood-brain barrier transport of cytokines; B. Cytokines in brain physiology Cytokines in synaptic function; Interleukin-2 as a Neuroregulatory Cytokine; Cytokines and Extracellular Matrix Remodeling in the Central Nervous System; Acidic fibroblast growth factor, a satiety substance, variegated physiological significance; Cytokines and Sleep; C. Chemokines in the brain; Chemokines, their receptors and significance in brain function; IV. Immune response in the brain; Immune and inflammatory responses in the CNS: modulation by astrocytes; Immune Response in the Brain: Glial Response and Cytokine Production; V. Cytokines in pathophysiological brain responses; A. Brain-immune interaction Lymphocytes and adrenergic sympathetic nerve system: the role of cytokines; Cytokines in Neural Signaling to the Brain; Interleukin-2 gene expression in CNS cells after stress and antigen application; Sex hormones and cytokines in CNS pathology and repair; Involvement of brain cytokines in stress-induced immunosuppression; Neuroprotective Effects of Inflammation in the Nerves System; VI. Disease; Brain Response to Endotoxin; Cytokines in Demyelinating Disease; The Cytokines and Depression Hypothesis: An Evaluation; Clinical Relevance: Cytokines in Alzheimer's Disease; VII. Cytokines and behaviour; Cytokines and immune-related behaviors; The production and effects of cytokines depend on brain lateralization;. This book opens a new page of neuro-immunobiology providing substantive experimental and clinical data to support current understanding in the field, and potential applications of this knowledge in the treatment of disease. The volume is a collection of complex, new data drawn from multiple areas of investigation in the field. The contents summarize current understanding on the presence and function of CNS cytokines and their receptors in a variety of CNS cells during health and disease. The chapters are a collection of complex, new data demonstrating the presence and synthesis of cytokines in brain cells, as well as their receptors on cell membranes in health and disease. The strength of the volume are the descriptions of the authors own investigations, together with those of others in the field pertaining to a large number of cytokines in brain function, as well as mechanisms involved in the development of CNS disorders, including multiple sclerosis and Alzheimer’s disease. Also included are novel approaches to the treatment of CNS disorders based on new experimental data. The contributors to this volume are internationally known scientists and clinical researchers in their respective fields of investigation and treatment.

*Opens a new page of neuro-immunobiology and provides substantive evidence for the promise of this field in the treatment of disease
*Summarizes current understanding on the presence and function of central nervous system (CNS) cytokines and their receptors in a variety of CNS cells during health and disease
*Includes novel approaches to the treatment of CNS disorders based on new experimental data
*Offers new insight into triggers for the development of autoimmune diseases in the brain and the possibilities for treatment This book opens a new page of neuro-immunobiology providing substantive experimental and clinical data to support current understanding in the field, and potential applications of this knowledge in the treatment of disease. The volume is a collection of complex, new data drawn from multiple areas of investigation in the field. The contents summarize current understanding on the presence and function of CNS cytokines and their receptors in a variety of CNS cells during health and disease. The chapters are a collection of complex, new data demonstrating the presence and synthesis of cytokines in brain cells, as well as their receptors on cell membranes in health and disease. The strength of the volume are the descriptions of the authors own investigations, together with those of others in the field pertaining to a large number of cytokines in brain function, as well as mechanisms involved in the development of CNS disorders, including multiple sclerosis and Alzheimer's disease. Also included are novel approaches to the treatment of CNS disorders based on new experimental data. The contributors to this volume are internationally known scientists and clinical researchers in their respective fields of investigation and treatment. *Opens a new page of neuro-immunobiology and provides substantive evidence for the promise of this field in the treatment of disease*Summarizes current understanding on the presence and function of central nervous system (CNS) cytokines and their receptors in a variety of CNS cells during health and disease*Includes novel approaches to the treatment of CNS disorders based on new experimental data*Offers new insight into triggers for the development of autoimmune diseases in the brain and the possibilities for treatment