Cytokines and Chemokines in Infectious Diseases Handbook (Infectious Disease)

Recent years have witnessed rapid growth in new information on the crucial role played by cytokines and chemokines in human disease, as well as on the exciting possibilities they offer for developing novel therapies and for optimizing vaccine performance. In the Cytokines and Chemokines in Infectious Diseases Handbook, international leaders in the field comprehensively review what is known about the responses of cytokines and chemokines to a variety of human infectious diseases, including gram-negative and gram-positive infections, listeriosis, mycobacterial infections, lyme arthritis, pneumonia, fungal infections, HIV, leishmaniasis, and sepsis. The authors demonstrate the different cytokine and chemokine production profiles in response to a wide range of pathogens and the importance of host genetic factors in determining the type and magnitude of responses to a given micro-organism. They also critically evaluate the use of cytokines and anticytokines in the treatment of infectious diseases and show how knowledge of cytokine pleiotropic effects, redundancy, and the complexity of the cytokine network has led to better design and better outcomes in cytokine-based therapies for specific infections. The book also offers important information for those working in biodefense research through its illustration of the role of cytokines and chemokines in modulating host-pathogen interactions and vaccine responses. Comprehensive and cutting-edge, the Cytokines and Chemokines in Infectious Diseases Handbook summarizes all the new scientific and clinical discoveries essential to understanding the importance of cytokines and chemokines in human infectious diseases, and demonstrates how best to utilize their unique properties in the design and development of effective new therapeutic agents. Introduction: Cytokine Biology Relevant To Infectious Diseases / Charles A. Dinarello -- 1. Leptin: Its Role In Immunomodulation And Susceptibility To Infection / Graham Lord -- 2. Cytokine Gene Polymorphism And Host Susceptibility To Infection / Frank Stuber -- 3. Proinflammatory And Anti-inflammatory Cytokines As Mediators Of Gram-negative Sepsis / Jean-marc Cavaillon -- 4. Host Response To Pathogenic Bacteria At Mucosal Sites / Laurence Arbibe And Philippe Sansonetti -- 5. Macrophage Migration Inhibitory Factor As A Cytokine Of Innate Immunity / Theirry Calandra -- 6. Cytokine Patterns In Severe Invasive Group A Streptococcal Infections / Anna Norrby-teglund And Malak Kotb -- 7. Superantigens And Bacterial Dna As Dytokine Inducers In Gram-positive Sepsis / Klaus Heeg -- 8. Cytokines And Chemokines In Listeriosis / Michael S. Rolph And Stefan H. E. Kaufmann -- 9. Regulation Of Cytokines And Chemokines In Human Mycobacterium Tuberculosis Infection / Zahra Toossi And Jerrold J. Ellner -- 10. Cytokines And Chemokines In Protective And Inflammatory Responses To Infection With Nontuberculous Mycobacteria / Stefan Ehlers -- 11. Human Interleikin-12 -- Interferon-[gamma] Axis In Protective Immunity To Mycobacteria / Claire Fieschi, Stephanie Dupuis, Capucine Picard And Jean-laurent Casanova -- 12. Role Of Th1 Cytokines In Host Defenses Against Mycobacterium Leprae / Elizabeth Pereira Sampaio, Milton Ozorio Moraes, M. Cristina Vidal Pessolani And Euzenir Nunes Sarno -- 13. Possible Role Of Molecular Mimicry In Lyme Arthritis / Abbie L. Meyer And Brigitte T. Huber -- 14. Cytokine Responses In Patients With Pneumonia / Peter Kragsbjerg And Hans Holmberg -- 15. Cytokines And The Host Defense Against Aspergillus Fumigatus / Emmanuel Roilides, Joanna Filioti And Cristina Gil-lamaignere -- 16. Cytokines Of Innate And Adaptive Immunity To Candida Albicans / Luigina Romani -- 17. Th1 And Th2 Cytokines In Leishmaniasis / Fabienne Tacchini-cottier, Genevieve Milon And Jacques A. Louis -- 18. Cytokines In The Regulation Of Innate And Adaptive Immunity To Toxoplasma Gondii / Ulrike Wille And Christopher A. Hunter -- 19. Viroceptors: Virus-encoded Receptors For Cytokines And Chemokines / Grant Mcfadden -- 20. Chemokines And Chemokine Receptors In Hiv Infection / Paolo Lusso -- 21. Cytokines In Viral Hepatitis / Mala K. Maini And Antonio Bertoletti -- 22. Interferon-[gamma] In The Treatment Of Infectious Diseases / Steven M. Holland And John I. Gallin -- 23. Interleukin-2 For The Treatment Of Hiv Infection / Guido Poli, Claudio Fortis, Adriano Lazzarin And Guiseppe Tambussi -- 24. Clinical Application Of G-csf And Gm-csf In The Treatment Of Infectious Diseases / Kai Hubel, David C. Dale, Richard K. Root And W. Conrad Liles -- 25. Anticytokine Therapies In Patients With Severe Sepsis And Septic Shock / Pierre-yves Bochud, Michel P. Glauser And Theirry Calandra -- 26. Intravenous Immunoglobulin Adjunctive Therapy In Patients With Streptococcal Toxic Shock Syndrome And Necrotizing Fasciitis / Ann Norrby-teglund, Donald E. Low And Malak Kotb. Edited By Malak Kotb, Thierry Calandra. Includes Bibliographical References And Index.

A comprehensive review of what is known about the role of cytokines and chemokines in a variety of human infectious diseases, including gram-negative and -positive infections, listeriosis, mycobacterial infections, lyme arthritis, pneumonia, fungal infections, HIV, leishmaniasis, and sepsis. The authors demonstrate the different cytokine and chemokine production profiles in response to a wide variety of pathogens and the importance of host genetic factors in determining the type and magnitude of responses to a given microorganism. They also critically evaluate the use of cytokines and anticytokines in the treatment of infectious diseases and show how knowledge of cytokine pleiotropic effects, redundancy, and the complexity of the cytokine network has led to better design and better outcomes in cytokine-based therapies for specific infections.

This handbook provides a reference on the role of cytokines and chemokines in a variety of human infectious diseases. International leaders in the field discuss the role of cytokines and chemokines in bacterial, viral, fungal and parasitic infections