Cytochrome Oxidase in Neuronal Metabolism and Alzheimer’s Disease

This book is based on an international symposium titled "Cytochrome oxidase in energy metabolism and Alzheimer's disease," held as a satellite to the 27th meeting of the Society for Neuroscience, New Orleans, 1997. The symposium was dedicated in honor of Dr. Margaret T. T. Wong-Riley because, in our opinion, the cytochrome oxidase histo­ chemical method introduced by Dr. Wong-Riley in 1979 was the most significant break­ through to map energy metabolism in the entire brain since the 2-deoxyglucose method introduced by Dr. Louis Sokoloff and colleagues in 1977. Both of these metabolic map­ ping techniques have made monumental contributions to brain research by allowing an integral view of brain activity. They have also developed into various specialized tech­ niques, including applications to the human brain. One of these new applications, which is described in detail in this book, is the quantitative cytochrome oxidase cytochemical method used to study Alzheimer's disease. The objective of this book is to describe the role of cytochrome oxidase in neuronal metabolism and Alzheimer's disease. Whether genetic or environmental, the pathogenesis of Alzheimer's disease involves a cascade of multiple intracellular events, eventually re­ sulting in failure of oxidative energy metabolism. Could impairment of cytochrome oxi­ dase in energy metabolism initiate the degenerative process? Cytochrome oxidase function and dysfunction are discussed in relationship to neuronal energy metabolism, neurodegen­ eration, and Alzheimer's disease. The book is made up of 10 chapters, divided into three major parts. This book is based on an international symposium titled "Cytochrome oxidase in energy metabolism and Alzheimer's disease," held as a satellite to the 27th meeting of the Society for Neuroscience, New Orleans, 1997. The symposium was dedicated in honor of Dr. Margaret T.T. Wong-Riley because, in our opinion, the cytochrome oxidase histoƯ chemical method introduced by Dr. Wong-Riley in 1979 was the most significant breakƯ through to map energy metabolism in the entire brain since the 2-deoxyglucose method introduced by Dr. Louis Sokoloff and colleagues in 1977. Both of these metabolic mapƯ ping techniques have made monumental contributions to brain research by allowing an integral view of brain activity. They have also developed into various specialized techƯ niques, including applications to the human brain. One of these new applications, which is described in detail in this book, is the quantitative cytochrome oxidase cytochemical method used to study Alzheimer's disease. The objective of this book is to describe the role of cytochrome oxidase in neuronal metabolism and Alzheimer's disease. Whether genetic or environmental, the pathogenesis of Alzheimer's disease involves a cascade of multiple intracellular events, eventually reƯ sulting in failure of oxidative energy metabolism. Could impairment of cytochrome oxiƯ dase in energy metabolism initiate the degenerative process? Cytochrome oxidase function and dysfunction are discussed in relationship to neuronal energy metabolism, neurodegenƯ eration, and Alzheimer's disease. The book is made up of 10 chapters, divided into three major parts Front Matter....Pages i-x Brain Cytochrome Oxidase....Pages 1-53 Quantitative Histochemistry of Cytochrome Oxidase Activity....Pages 55-90 Cytochrome Oxidase and Neuroanatomical Patterns....Pages 91-108 Functional Mapping of Learning-Related Metabolic Activity with Quantitative Cytochrome Oxidase Histochemistry....Pages 109-144 Functional Imaging Probes to Study the Neural Bases of Behavior in Genetic Animal Models of ADHD....Pages 145-169 Cytochrome Oxidase Inhibition In Alzheimer’s Disease....Pages 171-201 Molecular Mechanisms of Impaired Mitochondrial Gene Expression in Alzheimer’s Disease....Pages 203-216 Behavioral, Electrophysiological, and Biochemical Consequences of Chronic Cytochrome Oxidase Inhibition in Rats....Pages 217-232 Cytochrome Oxidase....Pages 233-261 Cytochrome Oxidase Atlas of Rat Brain....Pages 263-280 Back Matter....Pages 281-289 Proceedings of an International Symposium held in New Orleans, Louisiana, October 28, 1997