Current views of fatty acid oxidation and ketogenesis : from organelles to point mutations : [proceedings of the 4th Fatty Acid Oxidation and Ketogenesis Conference, held April 3-6 1998, in London, England

Content: Preliminaries; Contents; 1. Biogenesis of the Rat Liver Mitochondrial Carnitine; 2. Subcellular Distribution of Mitochondrial Carnitine Palmitoyltransferase I in Rat Liver; 3. Topology of Hepatic Mitochondrial Carnitine Palmitoyltransferase I; 4. Possible Involvement of Cytoskeletal Components in the Control of Hepatic Carnitine Palmitoyltransferase I Activity; 5. Effects of 3-Thia Fatty Acids on ß-Oxidation and Carnitine Palmitoyltransferase I Activity in Cultured Rat Hepatocytes; 6. Carnitine Acyltransferases and Associated Transport Processes in the Endoplasmic Reticulum. Abstract: Bringing together biochemical, genetic, molecular biology, and clinical approaches to the study of fatty acid oxidation, this text includes late-1990s research from most of the major groups working in this field. Read more...

This book brings together biochemical, genetic, molecular biology, and clinical approaches to the study of fatty acid oxidation. Including current research from most of the major groups working in this field, it provides a multi-disciplinary approach to the subject and an up-to-date overview of the most recent developments and debates.

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From an April 1998 conference in London, 46 papers report on research into the phenomena in such fields as biochemistry, physiology, molecular biology, and clinical medicine, especially as it is increasingly informed by molecular genetics and related techniques. Among the topics are the biogenesis of the rat liver mitochondrial carnitine palmitoyltransferase I, the kinetic investigation of carnitive palmitoyltransferases in homogenates of human skeletal muscle using L-amino-carnitine and malonyl-CoA, endotoxin-induced changes in very-low-density lipoprotein and myocardial utilization of triacylglycerol from abnormal VLDL in the rat, new insights into the functions and dysfunctions of peroxisome in fatty acid alpha and beta oxidation, and a rationale for a conditional knockout mouse model to study carnitine palmitoyltransferase I deficiencies. Annotation c. Book News, Inc., Portland, OR (booknews.com)