Current Trends in Organic Synthesis : Proceedings of the Fourth International Conference on Organic Synthesis, Tokyo, Japan, 22-27 August 1982

Current Trends in Organic Synthesis is a collection of papers presented at the Fourth International Conference on Organic Synthesis, held in Tokyo, Japan on August 22-27, 1982. This conference brings together the significant achievements in the diversified frontier fields of organic synthesis. This book is composed of 33 chapters. The first chapters focus on the synthesis of biologically active natural compounds, including metabolites of arachidonic acid, erythromycin A, verrucarins, steroids, anthracyclines, terpenes, yeast alanine t-RNA, beta-lactam antibiotics, and palitoxin. Other chapters deal with the central problems in stereoselective and chiral synthesis, as well as processes of high degree of stereochemical control and asymmetric induction. These chapters also describe chiral pool synthesis by means of carbohydrate precursors. This book also examines the methodologies in organic synthesis using reagents with boron, aluminum, transition metals, silicon, phosphorus, and sulfur. The remaining chapters are devoted to reactions involving radical initiated ring closure, small ring hydrogenolysis, annulene synthesis, vicarious nucleophilic substitution of aromatic hydrogen, and dichlorine monoxide mediated powerful chlorination. This book is of value to organic chemists and allied scientists. Content: Some Other IUPAC Titles of Interest from Pergamon Press , Page ii Front Matter , Page iii Copyright , Page iv Organizing Committee , Page vii PREFACE , Pages ix-x , Teruaki Mukaiyama, Hitosi Nozaki ACKNOWLEDGEMENTS , Pages xi-xii LEUKOTRIENES AND OTHER EICOSANOIDS: SYNTHESES AND SYNTHETIC METHODS , Pages 1-14 , E.J. Corey SYNTHETIC APPROACHES TO BIOLOGICALLY ACTIVE PROSTACYCLIN-ANALOGUES , Pages 15-25 , W. Bartmann, G. Beck, J. Knolle, R.H. Rupp THE ALDOL CONDENSATION AS A TOOL FOR STEREOSELECTIVE ORGANIC SYNTHESIS , Pages 27-43 , Clayton H. Heathcock STUDIES DIRECTED TOWARDS VERRUCARINS: A SYNTHESIS OF VERRUCAROL. AN APPROACH TO VERRUCARIN A , Pages 45-60 , Barry M. Trost, Patrick G. McDougal, James H. Rigby NEW APPROACHES TO THE TOTAL SYNTHESIS OF BIOLOGICALLY ACTIVE NATURAL PRODUCTS , Pages 61-70 , Michael E. Jung STUDIES DIRECTED TOWARDS THE CHEMICAL SYNTHESIS OF YEAST ALANINE tRNA , Pages 71-81 , Simon S. Jones, Colin B. Reese, Samson Sibanda SYNTHETIC ASPECTS OF 1-OXACEPHEM ANTIBIOTICS , Pages 83-100 , Wataru Nagata STUDIES RELATED TO BETA-LACTAM COMPOUNDS , Pages 101-114 , Saul Wolfe STEREOCHEMISTRY OF PALYTOXIN , Pages 115-130 , Yoshito Kishi DIASTEREO- AND ENANTIO-SELECTIVE CYCLOADDITION AND ENE REACTIONS IN ORGANIC SYNTHESIS , Pages 131-149 , Wolfgang Oppolzer REGIO-, DIASTEREO-, AND ENANTIOSELECTIVE C-C COUPLING REACTIONS USING METALATED HYDRAZONES, FORMAMIDES, ALLYLAMINES, AND AMINONITRILES , Pages 151-168 , D. Enders A NEW METHODOLOGY FOR THE GENERATION OF o-QUINODIMETHANES AND RELATED INTERMEDIATES — AN APPROACH TO ASYMMETRIC SYNTHESIS OF POLYCYCLES , Pages 169-175 , Yoshihiko Ito ASYMMETRIC SYNTHESIS USING ENANTIOMERICALLY PURE SULFOXIDES , Pages 177-180 , Gary H. Posner, Kyo Miura, John P. Mallamo, Martin Hulce, Timothy P. Kogan STEREOCONTROL VIA CYCLIZATION REACTIONS , Pages 181-191 , Paul A. Bartlett STEREOCONTROLLED SYNTHESIS OF 25S,26-DIHYDROXY- AND 1α, 25S, 26-TRIHYDROXYCHOLECALCIFEROL SIDE CHAINS , Pages 193-196 , Andrew D. Batcho, John Sereno, Naresh K. Chadha, John J. Partridge, Enrico G. Baggiolini, Milan R. Uskoković CARBOHYDRATE DERIVATIVES IN THE ASYMMETRIC SYNTHESIS OF NATURAL PRODUCTS , Pages 197-204 , Bert Fraser-Reid, Leon Magdzinski, Bruce Molino CARBOHYDRATES AS “CHIRAL TEMPLATES” IN ORGANIC SYNTHESIS – TARGET: BOROMYCIN , Pages 205-219 , Stephen Hanessian, Daniel Delorme, Peter C. Tyler, Gilles Demailly, Yves Chapleur STEREOCHEMICAL CONTROL IN MACROCYCLE SYNTHESIS , Pages 221-232 , E. Vedejs, J.M. Dolphin, D.M. Gapinski, H. Mastalerz STEREOCHEMICAL CONTROL IN MACROCYCLIC COMPOUNDS , Pages 233-246 , W. Clark Still NEW HYDROBORATING AGENTS , Pages 247-268 , Herbert C. Brown PALLADIUM- OR NICKEL-CATALYZED CROSS COUPLING INVOLVING PROXIMALLY HETEROFUNCTIONAL REAGENTS , Pages 269-280 , Ei-ichi Negishi SELECTIVE REACTIONS USING ORGANOALUMINUM REAGENTS , Pages 281-289 , Hisashi Yamamoto, Keiji Maruoka NEW ACCESS TO CONJUGATED DIENES VIA CARBOCUPRATION OF ALKYNES , Pages 291-302 , Jean F. Normant, Alexandre Alexakis QUINONE SYNTHESIS WITH ORGANOMETALLIC REAGENTS , Pages 303-310 , M.F. Semmelhack, Tadahisa Sato, J. Bozell, L. Keller, W. Wulff, A. Zask, E. Spiess ORGANO-SILICON MEDIATED SYNTHETIC REACTIONS , Pages 311-322 , Isao Kuwajima TRIMETHYLSILANOL AS A LEAVING GROUP IN PREPARATIVE ORGANIC CHEMISTRY , Pages 323-330 , Helmut Vorbrüggen REACTION OF SILYL ENOL ETHERS WITH CARBENES AND CARBENOIDS. NEW SYNTHESES OF VARIOUS CARBONYL COMPOUNDS , Pages 331-345 , Jean-Marie Conia, Luis Blanco A NEW SYNTHETIC APPROACH TO 1,4-DICARBONYL SYSTEMS AND FUNCTIONALIZED CYCLOPENTENONES BASED ON THE HORNER-WITTIG REACTION OF PHOSPHONATES CONTAINING SULFUR , Pages 347-358 , Marian Mikolajczyk VINYL AND BETA-ALKOXY RADICALS IN ORGANIC SYNTHESIS , Pages 359-370 , Gilbert Stork SELECTIVE HYDROGENOLYSIS OF C-C BONDS IN SMALL RING COMPOUNDS , Pages 371-378 , Hans Musso RECENT SYNTHETIC DEVELOPMENTS IN ANNULENE CHEMISTRY , Pages 379-400 , Emanuel Vogel VICARIOUS NUCLEOPHILIC SUBSTITUTION OF HYDROGEN. A NEW METHOD OF NUCLEOPHILIC ALKYLATION OF NITROARENES , Pages 401-412 , Mieczyslaw Makosza DICHLORINE MONOXIDE. A POWERFUL AND SELECTIVE CHLORINATING REAGENT , Pages 413-422 , D.J. Sam, F.D. Marsh, W.B. Farnham, B.E. Smart INDEX , Pages 423-429