Current Topics in Microbiology and Immunology, Volume 349: NF-kB in Health and Disease

This volume is focused on a transcription factor that started its life as a B cell-specific nuclear protein, but has matured to become one of the most extensively studied transcriptional regulators, found to control many pathophysiological processes: NF-kB. Articles in the volume, all of them written by the leading experts in the field, range from description of the NF-kB system and its basic components, its logic and its transcriptional regulatory functions to its participation in diverse processes, including inflammation, immunity, mucosal homeostasis and cancer. In addition to discussing the molecular biology and physiology of the NF-kB system, this volume also addresses the therapeutic targeting of NF-kB and its regulators. Thus, this volume is an important reading to both basic and translational scientists interested in different aspects of this highly versatile regulatory system. Understanding The Logic Of Ikappab:nf-kappab Regulation In Structural Terms / T. Huxford, A. Hoffmann And G. Ghosh -- Nf-kappab/rel Proteins And The Humoral Immune Responses Of Drosophila Melanogaster / S. Ganesan ... [et Al.] -- Specialized Chromatin Patterns In The Control Of Inflammatory Gene Expression / G. Natoli -- Ikk Regulation And Human Genetics / G. Courtois And A. Israel -- Control Of Nf-kappab Activity By Proteolysis / V. Baud And E. Derudder -- Nf-kappab And Innate Immunity / A. Dev ... [et Al.] -- Nf-kappab And Mucosal Homeostasis / L. Eckmann And A.s. Neish -- Ikk- And Nf-kappab-mediated Functions In Carcinogenesis / M.c. Arkan And F.r. Greten -- Macrophages And Nf-kappab In Cancer / T. Lawrence -- Nf-kappab In Liver Cancer: The Plot Thickens / S. Finkin And E. Pikarsky -- Nf-kappab As A Target For Oncogenic Viruses / S.c. Sun And E. Cesarman -- Inhibition Of Nf-kappab Signaling As A Strategy In Disease Therapy / T.d. Gilmore And M.r. Garbati. Michael Karin, Editor. Includes Bibliographical References And Index. Front Matter....Pages i-viii Understanding the Logic of IκB:NF-κB Regulation in Structural Terms....Pages 1-24 NF-κB/Rel Proteins and the Humoral Immune Responses of Drosophila melanogaster ....Pages 25-60 Specialized Chromatin Patterns in the Control of Inflammatory Gene Expression....Pages 61-72 IKK Regulation and Human Genetics....Pages 73-95 Control of NF-κB Activity by Proteolysis....Pages 97-114 NF-κB and Innate Immunity....Pages 115-143 NF-κB and Mucosal Homeostasis....Pages 145-158 IKK- and NF-κB-Mediated Functions in Carcinogenesis....Pages 159-169 Macrophages and NF-κB in Cancer....Pages 171-184 NF-κB in Liver Cancer: The Plot Thickens....Pages 185-196 NF-κB as a Target for Oncogenic Viruses....Pages 197-244 Inhibition of NF-κB Signaling as a Strategy in Disease Therapy....Pages 245-263 Back Matter....Pages 265-268 Nearly 25 years of intensive research have uncovered many diverse functions for the dimeric transcription factor known as NF-kappaB (nuclear factor-kappaB). NF-kappaB affects most aspects of cellular physiology—from immunity and inflammation to apoptosis, cell survival, growth, and proliferation