Current Topics in Microbiology and Immunology: Marek's Disease (Current Topics in Microbiology and Immunology)

"Marek's disease virus (MDV) is a herpesvirus which causes a lymphoproliferative disorder of the domestic chicken worldwide. The serious economical problem caused by MDV was mostly solved by development of an effective vaccine against MDV. The development of live vaccines against the disease is remarkable as it has led to the first example of a commercially available vaccine against cancer as well as against diseases caused by herpesviruses. This volume gives an overview on many aspects of MDV research and summarizes recent advances in the field. The topics include the history, biology and molecular biology of MDV, pathogenesis, vaccinal immunity, immune response, genetic resistance and development of recombinant polyvalent vaccines. It is hoped that this volume will make an important contribution towards the control of infectious diseases."--BOOK JACKET The History And Biology Of Marek's Disease Virus / P.m. Biggs -- Pathogenesis Of Marek's Disease Virus Infection / B.w. Calnek -- Protective Efficacy Of Marek's Disease Vaccines / R.l. Witter -- Immune Responses To Marek's Disease Virus Infection / K.a. Schat And C.j. Markowski-grimsrud -- Genetic Resistance To Marek's Disease / L.d. Bacon, H.d. Hunt, And H.h. Cheng -- The Genomic Structure Of Marek's Disease Virus / R.f. Silva, L.f. Lee, And G.f. Kutish -- Protein-coding Content Of The Sequence Of Marek's Disease Virus Serotype 1 / B. Lupiani, L.f. Lee, And S.m. Reddy -- A Complete Genomic Dna Sequence Of Marek's Disease Virus Type 2, Strain Hprs24 / Y. Izumiya ... [et Al.] -- Marek's Disease Virus Latency / R.w. Morgan ... [et Al.] -- Meq : An Mdv-specific Bzip Transactivator With Transforming Properties / H.-j. Kung ... [et Al.] -- Polyvalent Recombinant Marek's Disease Virus Vaccine Against Poultry Diseases / K. Hirai And M. Sakaguchi. Edited By K. Hirai. Includes Bibliographical References And Index. Marek's disease virus (MDV) is a herpesvirus which causes a lymphoproliferative disorder of the domestic chicken worldwide. This serious economical problem caused by MDV was mostly solved by development of an effective vaccine against MDV. The development of live vaccines against the disease is remarkable as it has led to the first example of a commercially available vaccine against cancer as well as against diseases caused by herpesviruses. This volume gives an overview on many aspects of MDV research and summarizes recent advances in the field. The topics include the history, biology,and molecular biology of MDV, pathogenesis, vaccinal immunity, immune response, genetic resistance and development of recombinant polyvalent vaccines. It is hoped that this volume will make an important contribution towards the control of infectious diseases. Front Matter....Pages I-X The History and Biology of Marek’s Disease Virus....Pages 1-24 Pathogenesis of Marek’s Disease Virus Infection....Pages 25-55 Protective Efficacy of Marek’s Disease Vaccines....Pages 57-90 Immune Responses to Marek’s Disease Virus Infection....Pages 91-120 Genetic Resistance to Marek’s Disease....Pages 121-141 The Genomic Structure of Marek’s Disease Virus....Pages 143-158 Protein-Coding Content of the Sequence of Marek’s Disease Virus Serotype 1....Pages 159-190 A Complete Genomic DNA Sequence of Marek’s Disease Virus Type 2, Strain HPRS24....Pages 191-221 Marek’s Disease Virus Latency....Pages 223-243 Meq: An MDV-Specific bZIP Transactivator with Transforming Properties....Pages 245-260 Polyvalent Recombinant Marek’s Disease Virus Vaccine Against Poultry Diseases....Pages 261-287 Back Matter....Pages 289-294 Marck's Disease (MD) was the term chosen in 1960 for a common lymphoproliferative disease principally of the domestic chicken (Gallus domesticus), which is now known to be caused by a cell-associated alpha herpesvirus.