Current Strategies in Cancer Gene Therapy (Recent Results in Cancer Research, 209)

This book describes important developments and emerging trends in experimental and clinical cancer gene therapy. It reflects the tremendous advances made over recent years with respect to immunogenes, suicide genes and gene correction therapies, as well as in gene suppression and miRNA therapies. Many of the described strategies focus on the generation of more efficient and specific means of attack at known and novel cellular targets associated with tumor development and progression. The book also details parallel improvements in vector design, vector delivery, and therapeutic efficacy. It offers readers a stimulating, broad overview of advances in the field, linking experimental strategies to their clinical applications. Front Matter....Pages i-v p53 Replacement Therapy for Cancer....Pages 1-15 Retroviral Vectors for Cancer Gene Therapy....Pages 17-35 Minicircle-Based Engineering of Chimeric Antigen Receptor (CAR) T Cells....Pages 37-50 Noncoding RNA for Cancer Gene Therapy....Pages 51-60 mRNA Cancer Vaccines....Pages 61-85 Gene Therapeutic Approaches to Overcome ABCB1-Mediated Drug Resistance....Pages 87-94 Bacterial Toxins for Oncoleaking Suicidal Cancer Gene Therapy....Pages 95-110 Use of Bacteria in Cancer Therapy....Pages 111-121 P53 Replacement Therapy For Cancer -- Retroviral Vectors For Cancer Gene Therapy -- Minicircle-based Engineering Of Chimeric Antigen Receptor (car) T Cells -- Noncoding Rna For Cancer Gene Therapy -- Mrna Cancer Vaccines -- Gene Therapeutic Approaches To Overcome Abcb1-mediated Drug Resistance -- Bacterial Toxins For Oncoleaking Suicidal Cancer Gene Therapy -- Use Of Bacteria In Cancer Therapy. Wolfgang Walther, Editor. Includes Bibliographical References.