Current research in head and neck cancer : molecular pathways, novel therapeutic targets, and prognostic factors ; new insights into basic and translational research

The development of head and neck cancer is a multistep process in which genetic as well as epigenetic alterations interfere with the regular functions of proto-oncogenes and tumor suppressor genes. In addition, carcinogenesis is promoted by the impairment of mechanisms responsible for the maintenance of genetic stability. The accumulation of crucial events such as evasion of apoptosis, lack of senescence, deregulated proliferation, invasion and metastasis, as well as neoangiogenesis eventually determines the malignant phenotype. The 16 articles of this volume span from advances in the understanding of underlying molecular pathways (conditional mouse model, folate activity, DNA repair, genomic heterogeneity, p53 family members, human papillomavirus), to preclinical and clinical studies investigating potential novel therapeutic targets (epidermal growth factor receptor, nuclear factor-kappaB, vascular endothelial growth factor, chemokine receptors, P53-based immunotherapy, virus-modified tumor vaccination), and biometric considerations on the evaluation of prognostic factors. This state-of-the-art publication is recommended reading not only for ENT specialists and oncologists, but also for molecular biologists and other subspecialists interested in head and neck cancer research. ASD ZONE.pdf......Page 1 00 Preliminary Pages.pdf......Page 2 01 Development of a Conditional Mouse Model for Head and Neck Squamous Cell Carcinoma.pdf......Page 8 02 Hypofolatemia as a Risk Factor for Head and Neck Cancer.pdf......Page 19 03 Reduced DNA Repair Capacity in Laryngeal Cancer Subjects.pdf......Page 32 04 Intratumoral Genomic Heterogeneity in Advanced Head and Neck Cancer Detected by Comparative Genomic Hybridization.pdf......Page 45 05 Function and Importance of p63 in Normal Oral Mucosa and Squamous Cell Carcinoma of the Head and Neck.pdf......Page 56 06 p53, p63 and p73 Expression in Squamous Cell Carcinomas of the Head and Neck and Their Response to Cisplatin Exposure.pdf......Page 65 07 Expression of p16 Protein Is Associated with Human Papillomavirus Status in Tonsillar Carcinomas and Has Implications on Survival.pdf......Page 79 08 EGFR-Antibody-Supplemented TPF Chemotherapy.pdf......Page 88 09 Nuclear Factor-KB as a Common Target and Activator of Oncogenes in Head and Neck Squamous Cell Carcinoma.pdf......Page 99 10 Antiangiogenic Therapy of Head and Neck Squamous Cell Carcinoma by Vascular Endothelial Growth Factor Antisense Therapy.pdf......Page 110 11 Chemokine Receptors 6 and 7 Identify a Metastatic Expression Pattern in Squamous Cell Carcinoma of the Head and Neck.pdf......Page 128 12 p53-Based Immunotherapy of Cancer.pdf......Page 141 13 p53 as an Immunotherapeutic Target in Head and Neck Cancer.pdf......Page 158 14 Imbalance in Absolute Counts of T Lymphocyte Subsets in Patients with Head and Neck Cancer and Its Relation to Disease1.pdf......Page 168 15 Antitumor Immunization of Head and Neck Squamous Cell Carcinoma Patients with a Virus-Modified Autologous Tumor Cell Vaccine.pdf......Page 180 16 Prognostic Factors.pdf......Page 191 17 Author index.pdf......Page 208 18 Subject Index.pdf......Page 209 Bier (otorhinolaryngology, Heinrich Heine U., Germany) presents 16 articles detailing recent work on understanding various aspects of head and neck cancer. The research papers discuss such topics as hypofolatemia as a risk factor, reduced DNA repair capacity in laryngeal cancer subjects, antiangiogenic therapy of head and neck squamous cell carcinoma by vascular endothelial growth factor antisense therapy, p53-based immunotherapy of cancer, and imbalance in absolute counts of T lymphocyte subsets in patients with head and neck cancer and its relation to disease. Annotation : 2004 Book News, Inc., Portland, OR (booknews.com) Contains 16 articles that span from advances in the understanding of underlying molecular pathways (conditional mouse model, folate activity, DNA repair, genomic heterogeneity, p53 family members, human papillomavirus), to preclinical and clinical studies investigating potential novel therapeutic targets.