Crossroads between Innate and Adaptive Immunity (Advances in Experimental Medicine and Biology Book 590)

This compilation presents minireviews derived from work presented at the - gean Conference: “First Crossroads between Innate and Adaptive Immunity,” which occurred October 9–14, 2005 at the Hilton Conference Center on the - land of Rhodes, Greece. The conference included sessions dedicated to host r- ognition of and response to pathogens, innate immune networks, antigen pres- tation, and adaptive immune responses, each headlined by a leading scientist at the forefront of that field. The intimate networking and interaction of dendritic cells, T cells, B cells, NK cells, NK-T cells, and complement during the host response to pathogens and tumors are only now starting to be elucidated. The respective fields that focus on these immune cells and molecules tend to exist in parallel worlds, with minimum exchange of information and ideas. The goal of this conference was to initiate crosstalk between these immunological fields, and to promote and facilitate discussion on the interactions between the innate - mune response and the adaptive immune response, and ultimately breed colla- ration between these areas of study. The “First Crossroads between Innate and Adaptive Immunity” Aegean Conference succeeded in bringing together and connecting scientists and experts from around the world to address critical areas of innate and adaptive immunity — something necessary for the development of more efficient scientific exchange and crosspollination between these fields. Front Matter....Pages i-xx Signal Transduction in DC Differentiation: Winged Messengers and Achilles’ Heel....Pages 1-29 Shaping Naive and Memory Cd8+ T Cell Responses in Pathogen Infections Through Antigen Presentation....Pages 31-42 Understanding the Role of Innate Immunity in the Mechanism of Action of the Live Attenuated Yellow Fever Vaccine 17D....Pages 43-53 The Function of Local Lymphoid Tissues in Pulmonary Immune Responses....Pages 55-68 The Yin and Yang of Adaptive Immunity in Allogeneic Hematopoietic Cell Transplantation: Donor Antigen-Presenting Cells Can Either Augment or Inhibit Donor T Cell Alloreactivity....Pages 69-87 It’s Only Innate Immunity But I Like it....Pages 89-101 Innate Tumor Immune Surveillance....Pages 103-111 Regulation of Adaptive Immunity by Cells of the Innate Immune System: Bone Marrow Natural Killer Cells Inhibit T Cell Proliferation....Pages 113-120 Induction and Maintenance of Cd8+ T Cells Specific for Persistent Viruses....Pages 121-137 Germinal Center-Derived B Cell Memory....Pages 139-148 CD28 and Cd27 Costimulation of Cd8+ T Cells: A Story of Survival....Pages 149-170 CD38: An Ecto-Enzyme at the Crossroads of Innate and Adaptive Immune Responses....Pages 171-183 Vascular Leukocytes: a Population with Angiogenic and Immunossuppressive Properties Highly Represented in Ovarian Cancer....Pages 185-193 CD4+ T Cells Cooperate With Macrophages for Specific Elimination of MHC Class II-Negative Cancer Cells....Pages 195-208 Receptors and Pathways in Innate Antifungal Immunity....Pages 209-221 Back Matter....Pages 223-232 This compilation presents minireviews derived from work presented at the Aegean Conference, which occurred October 9-14, 2005 at the Hilton Conference. Center on the island of Rhodes, Greece. The conference included sessions dedicated to host recognition of and response to pathogens, innate immune networks, antigen presentation, and adaptive immune responses, each headlined by a leading scientist at the forefront of that field. The intimate networking and interaction of dendritic cells, T cells, B cells, NK cells, NK-T cells, and complement during the host response to pathogens and tumors are only now starting to be elucidated.

This compilation presents mini-reviews derived from work presented at the Aegean Conference: First Crossroads between Innate and Adaptive Immunity, which occurred in October, 2005 at the Hilton Conference Center on the island of Rhodes, Greece. The conference included sessions dedicated to host recognition of and response to pathogens, innate immune networks, antigen presentation, and adaptive immune responses, each headlined by a leading scientist.