Creatine and Creatine Kinase in Health and Disease (Subcellular Biochemistry (46))

Although creatine was discovered already in the 1830s, it is only in recent years that its crucial role for human health and general well-being has been increasingly realized and appreciated. A number of beneficial health effects have been ascribed to oral creatine supplementation, such as neuroprotective, ergogenic, anti-diabetic, anti-inflammatory, antiviral, or antitumor effects. Creatine may even improve memory and intelligence. In the present book, emphasis is placed on the intricate interplay between creatine and creatine kinase function on one hand, and proper brain function, neurodegenerative disease and/or neuroprotection on the other hand. The book also elaborates on the recently identified inborn errors of creatine biosynthesis and transport, the so-called cerebral creatine deficiency syndromes. The clinical hallmarks of these disorders are mental retardation, epilepsy, autistic-like behaviour, and speech and language delay. In addition, the muscle growth- and strength-promoting effects, the pharmacokinetics and the safety of oral creatine supplementation are discussed. Finally, the present book outlines the emerging "systems biology" approaches for understanding the pleiotropic effects of creatine and creatine kinase, and hypothesizes on the most promising and influential future avenues of research towards creatine-based nutritional strategies for the prevention of neurological disease, and for improving the quality of life in general. 1. Introduction: Creatine: Cheap Ergogenic Supplement With Great Potential For Health And Disease / Theo Walliman -- 2. Early Evolution Of The Creatine Kinase Gene Family And The Capacity For Creatine Biosynthesis And Membrane Transport / W. Ross Ellington And Tomohiko Suzuki -- 3. The Creatine Kinase Phosphotransfer Network: Thermodynamic And Kinetic Considerations, The Impact Of The Mitochondrial Outer Membrane And Modelling Approaches / Valdur Saks [and Others] -- 4. Expression And Function Of Agat, Gamt And Ct1 In The Mammalian Brain / Olivier Braissant, Claude Bachmann And Hugues Henry -- 5. A Novel Relationship Between Creatine Transport At The Blood-brain And Blood-retinal Barriers, Creatine Biosynthesis, And Its Use For Brain And Retinal Energy Homeostasis / Masanori Tachikawa [and Others] -- 6. Functional Insights Into The Creatine Transporter / David L. Christie -- 7. In Vivo Magnetic Resonance Spectroscopy Of Transgenic Mice With Altered Expression Of Guanidinoacetate Methyltransferase And Creatine Kinase Isoenzymes / Arend Heerschap [and Others] -- 8. Cerebral Creatine Deficiency Syndromes: Clinical Aspects, Treatment And Pathophysiology / Sylvia Stockler, Peter W. Schutz And Gajja S. Salomons -- 9. Pre-symptomatic Treatment Of Creatine Biosynthesis Defects / Andreas Schultze And Roberta Battini -- 10. Clinical Use Of Creatine In Neuromuscular And Neurometabolic Disorders / Mark A. Tarnopolsky -- 11. The Neuroprotective Role Of Creatine / Autumn M. Klein And Robert J. Ferrante -- 12. Ergogenic Effects Of Creatine In Sports And Rehabilitation / Peter Hespel And Wim Derave -- 13. Pharmacokinetics Of Creatine / Wesley Mccall And Adam M. Persky -- 14. Safety Of Creatine Supplementation / Adam M. Persky And Eric S. Rawson -- 15. Creatine: Its Chemical Synthesis, Chemistry, And Legal Status / Ivo Pischel And Thomas Gastner -- 16. Creatine And Creatine Kinase In Health And Disease: A Bright Future Ahead? / Markus Wyss [and Others]. Edited By Gajja S. Salomons And Markus Wyss. Includes Bibliographical References And Index. Front Matter....Pages I-XVII Introduction – Creatine: Cheap Ergogenic Supplement with Great Potential for Health and Disease....Pages 1-16 Early Evolution of the Creatine Kinase Gene Family and the Capacity for Creatine Biosynthesis and Membrane Transport....Pages 17-26 The Creatine Kinase Phosphotransfer Network: Thermodynamic and Kinetic Considerations, the Impact of the Mitochondrial Outer Membrane and Modelling Approaches....Pages 27-65 Expression and Function of Agat, Gamt and CT1 in the Mammalian Brain....Pages 67-81 A Novel Relationship Between Creatine Transport at the Blood-Brain and Blood-Retinal Barriers, Creatine Biosynthesis, And its Use for Brain and Retinal Energy Homeostasis....Pages 83-98 Functional Insights into the Creatine Transporter....Pages 99-118 In Vivo Magnetic Resonance Spectroscopy of Transgenic Mice with Altered Expression of Guanidinoacetate Methyltransferase and Creatine Kinase Isoenzymes....Pages 119-148 Cerebral Creatine Deficiency Syndromes: Clinical Aspects, Treatment and Pathophysiology....Pages 149-166 Pre-Symptomatic Treatment of Creatine Biosynthesis Defects....Pages 167-181 Clinical Use of Creatine in Neuromuscular and Neurometabolic Disorders....Pages 183-204 The Neuroprotective Role of Creatine....Pages 205-243 Ergogenic Effects of Creatine in Sports and Rehabilitation....Pages 246-259 Pharmacokinetics of Creatine....Pages 262-273 Safety of Creatine Supplementation....Pages 275-289 Creatine – its Chemical Synthesis, Chemistry, and Legal Status....Pages 291-307 Creatine and Creatine Kinase in Health and Disease – A Bright Future Ahead?....Pages 309-334 Back Matter....Pages 335-351 A number of beneficial health effects have been ascribed to oral creatine supplementation. Creatine may even improve memory and intelligence. This book emphasizes on the intricate interplay between creatine and creatine kinase function and proper brain function, neurodegenerative disease and/or neuroprotection 0salomPrel.pdf -1 0salom01.pdf -1 0salom02.pdf -1 0salom03.pdf -1 0salom04.pdf -1 0salom05.pdf -1 0salom06.pdf -1 0salom07.pdf -1 0salom08.pdf -1 0salom09.pdf -1 0salom10.pdf -1 0salom11.pdf -1 0salom12.pdf -1 0salom13.pdf -1 0salom14.pdf -1 0salom15.pdf -1 0salom16.pdf -1 0salomIndex.pdf -1