CRC handbook of animal models models of pulmonary disease vol II

"This two-volume handbook provides important information concerning the development, implementation, evaluation, uses, advantages, and limitations of a wide variety of animal model of pulmonary disease. While the work focuses on stepwise procedures for inducing and quantifying disease, additional emphasis is placed on each model's relationship to human counterparts and on comparisons with similar models of injury. Thus, even the novice researcher will be able to more sharply define a particular research question, find suitable animal models for study, gain access to specialized techniques, and evaluate results within the context of an up-to-date body of information about related forms of lung diseases."--Provided by publisher Content: Volume I: Animal Models of Hyperoxic Lung Injury Ozone-Induced Lung Injury Sheep as an Animal Model of Endotoxemia-Induced Diffuse Lung Injury injury to the Isolated, Perfused Lung Induced by Phorbol Myristate Acetate Nitrosourethane-Induced Lung Injury Immune Complex Injury Bleomycin-Induced Pulmonary Fibrosis Amiodarone-Induced Pulmonary Fibrosis The Paraquat Model of Lung Fibrosis Radiation-Induced Interstitial Lung Disease Silica-Induced Pulmonary Fibrosis Lung Response to Cigarette Smoke Inhalation: An Animal Model Index The potential for adverse effects from exposure to hyperoxia was suspected by Priestly more than 2 centuries ago: " . . . for, as a candle burns outs much faster in dephlogisticated than in common air, so we might, as may be said, live out too fast, and the animal powers be too soon exhausted in this pure kind of air." Pulmonary emphysema is characterized by damage to elastic fibers in the lung interstitium.