Coxiella Burnetii: Recent Advances And New Perspectives In Research Of The Q Fever Bacterium (advances In Experimental Medicine And Biology)

Annotation Coxiella Burnetii Is The Etiological Agent Of Q Fever, A Zoonotic Disease Found Worldwide. The Bacterium Is A Fascinating Example Of Intracellular Parasitism That Has Uniquely Evolved To Thrive In The Most Inhospitable Of Cellular Compartments-the Phagolysosome. Understanding How C. Burnetii Resists The Degradative Functions Of This Vacuole, And The Host Cell Functions Coopted For Successful Parasitism, Are Central To Understanding Q Fever Pathogenesis. Recent Achievements In Glycomics And Proteomics Are Guiding Development Of Enhanced Detection Schemes For The Bacterium In Addition To Shedding Light On The Host Immune Response To The Pathogen. Several Chapters Survey Immune Functions That Control Or Potentially Exacerbate Coxiella Infection And Delve Into Correlates Of Protective Immunity Elicited By Vaccination. Comparative Genomics Is Also The Foundation Of Chapters Discussing Diagnostic Antigen Discovery And Molecular Typing Of The Bacterium, With Significance For Development Of New Clinical, Epidemiologic, And Forensic Tools. History And Prospects Of Coxiella Burnetii Research / Karim E. Hechemy -- Phylogenetic Diversity, Virulence And Comparative Genomics / Erin J. Van Schaik And James E. Samuel -- Defense Mechanisms Against Oxidative Stress In Coxiella Burnetii: Adaptation To A Unique Intracellular Niche / Katja Mertens And James E. Samuel -- Lipopolysaccharide Of Coxiella Burnetii / Craig T. Narasaki And Rudolf Toman -- Components Of Protective Immunity / Guoquan Zhang, Yan Zhang And James E. Samuel -- Proteome Of Coxiella Burnetii / Robert Ihnatko, Edward Shaw And Rudolf Toman -- Coxiella Subversion Of Intracellular Host Signaling / S. Kauser Hussain And Daniel E. Voth -- The Coxiella Burnetii Parasitophorous Vacuole / Eric Ghigo, María I. Colombo And Robert A. Heinzen -- Coxiella Burnetii Secretion Systems / Justin A. Mcdonough, Hayley J. Newton And Craig R. Roy. Role Of Lipids In Coxiella Burnetii Infection / Stacey D. Gilk -- Axenic Growth Of Coxiella Burnetii / Anders Omsland -- Developmental Biology Of Coxiella Burnetii / Michael F. Minnick And Rahul Raghavan -- Genetic Manipulation Of Coxiella Burnetii / Paul A. Beare -- Role Of Innate And Adaptive Immunity In The Control Of Q Fever / Christian Capo And Jean-louis Mege -- Immune Response And Coxiella Burnetii Invasion / Amira Ben Amara, Yassina Bechah And Jean-louis Mege -- Antigenic Analysis For Vaccines And Diagnostics / Laura R. Hendrix And Chen Chen -- Epidemic Q Fever In Humans In The Netherlands / Wim Van Der Hoek, Gabriëlla Morroy, Nicole H. M. Renders, Peter C. Wever And Mirjam H. A. Hermans, Et Al. -- Coxiella-like Endosymbionts / Jianmin Zhong -- Molecular Typing Of Coxiella Burnetii (q Fever) / Robert F. Massung, Sally J. Cutler And Dimitrios Frangoulidis. Edited By Rudolf Toman ... [et Al.]. Includes Bibliographical References And Index. Front Matter....Pages i-xiv History and Prospects of Coxiella burnetii Research....Pages 1-11 Phylogenetic Diversity, Virulence and Comparative Genomics....Pages 13-38 Defense Mechanisms Against Oxidative Stress in Coxiella burnetii : Adaptation to a Unique Intracellular Niche....Pages 39-63 Lipopolysaccharide of Coxiella burnetii ....Pages 65-90 Components of Protective Immunity....Pages 91-104 Proteome of Coxiella burnetii ....Pages 105-130 Coxiella Subversion of Intracellular Host Signaling....Pages 131-140 The Coxiella burnetii Parasitophorous Vacuole....Pages 141-169 Coxiella burnetii Secretion Systems....Pages 171-197 Role of Lipids in Coxiella burnetii Infection....Pages 199-213 Axenic Growth of Coxiella burnetii ....Pages 215-229 Developmental Biology of Coxiella burnetii ....Pages 231-248 Genetic Manipulation of Coxiella burnetii ....Pages 249-271 Role of Innate and Adaptive Immunity in the Control of Q Fever....Pages 273-286 Immune Response and Coxiella burnetii Invasion....Pages 287-298 Antigenic Analysis for Vaccines and Diagnostics....Pages 299-328 Epidemic Q Fever in Humans in the Netherlands....Pages 329-364 Coxiella -like Endosymbionts....Pages 365-379 Molecular Typing of Coxiella burnetii (Q Fever)....Pages 381-396 Back Matter....Pages 397-406 Over 20 years have elapsed since publication of the seminal two volume series entitled Q Fever: The Biology of Coxiella burnetii (edited by J.C. Williams and H.A. Thompson) and Q fever: The Disease (edited by T.J. Marrie) that described the current state of Coxiella burnetii research. The ensuing years have brought the post-genomic era and accompanying technologies that have catalyzed major advances in the field, including milestones discoveries of genetic transformation and host cell-free growth of this former obligate intracellular bacterium. Understanding how the bacterium resists the degradative functions of vacuole, and the host cell functions coopted for successful parasitism, are central to understanding Q fever pathogenesis. Recent achievements in glycomics and proteomics are guiding development of enhanced detection schemes for the bacterium in addition to shedding light on the host immune response to the pathogen. ℗¡ The book covers the current state-of-the-art knowledge in the selected fields of C. burnetii/Q fever research. Coxiella has matured from a niche organism, investigated by a handful of laboratories worldwide, to a model system to study macrophage parasitism, developmental biology, host-pathogen interactions, and immune evasion/modulation