Covalent analogues of DNA base-Pairs and triplets. Part 2: † †For Part I, see ref 1. Synthesis and cytostatic activity of bis(purin-6-yl)acetylenes,-diacetylenes and related compounds

معرفی کتاب «Covalent analogues of DNA base-Pairs and triplets. Part 2: † †For Part I, see ref 1. Synthesis and cytostatic activity of bis(purin-6-yl)acetylenes,-diacetylenes and related compounds» نوشتهٔ Michal Hocek; Ivan Votruba، منتشرشده توسط نشر Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X). این کتاب در فرمت pdf، زبان انگلیسی ارائه شده است.

The title bis(purin-6-yl)acetylenes, -diacetylenes, -ethylenes and -ethanes were prepared as covalent base-pair analogues starting from 6-ethynylpurines and 6-iodopurines by cross-coupling and homo-coupling reactions and hydrogenations. The bis(purin-6-yl)acetylenes and -diacetylenes exhibited significant cytostatic activity in vitro (IC 50 =0.4-1.0 mmol/l).

دانلود کتاب Covalent analogues of DNA base-Pairs and triplets. Part 2: † †For Part I, see ref 1. Synthesis and cytostatic activity of bis(purin-6-yl)acetylenes,-diacetylenes and related compounds