Cortical development genes and genetic abnormalities : [Symposium held at the Novartis Foundation, London, 6-8 February 2007

To understand the brain and its devastating diseases, we need to reveal the mechanisms that produce it and the ways in which it can constantly change throughout a lifetime. This book features a timely and insightful discussion between developmental neurobiologists and clinicians who deal with disorders of the nervous system. Chapters in this book deal specifically with cell fate determination, cell migration and disorders of cell migration; current concepts and new ideas about cortical arealisation, and disorders which can arise from incorrect arealisation; genes implicated in the development of cortical connectivity and related pathologies such as schizophrenia and synaesthesia; and susceptibility genes for cognitive disorders such as schizophrenia, autism, dyslexia, and attention deficit disorder. Molecular Development Of Corticospinal Motor Neuron Circuitry / Bradley J. Molyneaux, Paola Arlotta And Jeffrey D. Macklis -- Perspectives On The Developmental Origins Of Cortical Interneuron Diversity / Gordon Fishell -- Genetic Determinants Of Neuronal Migration In The Cerebral Cortex / Pasko Rakic, Kazue Hashimoto-torii And Matthew R. Sarkisian -- Neural Stem And Progenitor Cells In Cortical Development / Stephen C. Noctor, Veronica Martinez-cerdeño And Arnold R. Kriegstein -- Genes That Control The Size Of The Cerebral Cortex / Teresa H. Chae And Christopher A. Walsh -- Control Of Cortical Neuron Layering : Lessons From Mouse Chimeras / Vicki Hammond, Joanne Britto, Eva So, Holly Cate And Seong-seng Tan -- Intracortical Multidirectional Migration Of Cortical Interneurons / Fujio Murakami, Daisuke Tanaka, Mitsutoshi Yanagida And Emi Yamazaki -- The Atypical Cadherin Celsr3 Regulates The Development Of The Axonal Blueprint / Libing Zhou, Fadel Tissir And André M. Goffinet --^ Regulation Of Laminar And Area Patterning Of Mammalian Neocortex And Behavioural Implications / Dennis D.m. O'leary, Shen-ju Chou, Tadashi Hamasaki, Setsuko Sahara, Akihide Takeuchi, Sandrine Thuret And Axel Leingärtner -- Genetic Regulation Of Prefrontal Cortex Development And Function / Jeremy A. Cholfin And John L.r. Rubenstein -- Self-organization And Pattern Formation In Primate Cortical Networks / Henry Kennedy, Rodney Douglas, Kenneth Knoblauch And Colette Dehay -- Molecular Mechanisms Of Thalamocortical Axon Targeting / Nobuhiko Yamamoto, Takuro Maruyama, Naofumi Uesaka, Yasufumi Hayano, Makoto Takemoto And Akito Yamada -- Genes Involved In The Formation Of The Earliest Cortical Circuits / Zoltán Molnár, Anna Hoerder-suabedissen, Wei Zhi Wang, Jamin Deproto, Kay Davies, Sheena Lee, Erin C. Jacobs, Anthony T. Campagnoni, Ole Paulsen, Maria Carmen Piñon And Amanda F.p. Cheung --^ Emx And Nfi Genes Regulate Cortical Development And Axon Guidance In The Telencephalon / Michael Piper, Amber-lee S. Dawson, Charlotta Lindwall, Guy Barry, Céline Plachez And Linda J. Richards -- Schizophrenia Susceptibility Genes And Their Neurodevelopmental Implications: Focus On Neuregulin 1 / Paul J. Harrison -- Focal Brain Malformations : A Spectrum Of Disorders Along The Mtor Cascade / Peter B. Crino. Chair: John Parnavelas--back Cover. Symposium On Cortical Development: Genes And Genetic Abnormalities, Held At The Novartis Foundation, London, 6-8 February 2007--contents P. Includes Bibliographical References And Indexes. CORTICAL DEVELOPMENT: GENES AND GENETIC ABNORMALITIES......Page 1 Contents......Page 7 Chair’s introduction......Page 15 Molecular development of corticospinal motor neuron circuitry......Page 17 DISCUSSION......Page 29 Perspectives on the developmental origins of cortical interneuron diversity......Page 35 DISCUSSION......Page 49 Genetic determinants of neuronal migration in the cerebral cortex......Page 59 DISCUSSION......Page 67 Neural stem and progenitor cells in cortical development......Page 73 DISCUSSION......Page 87 Genes that control the size of the cerebral cortex......Page 93 DISCUSSION......Page 105 General Discussion I......Page 110 Control of cortical neuron layering: lessons from mouse chimeras......Page 113 DISCUSSION......Page 122 Intracortical multidirectional migration of cortical interneurons......Page 130 DISCUSSION......Page 139 The atypical cadherin Celsr3 regulates the development of the axonal blueprint......Page 144 DISCUSSION......Page 148 Regulation of laminar and area patterning of mammalian neocortex and behavioural implications......Page 155 DISCUSSION......Page 173 Genetic regulation of prefrontal cortex development and function......Page 179 DISCUSSION......Page 187 Self-organization and pattern formation in primate cortical networks......Page 192 DISCUSSION......Page 209 Molecular mechanisms of thalamocortical axon targeting......Page 213 DISCUSSION......Page 222 Genes involved in the formation of the earliest cortical circuits......Page 226 DISCUSSION......Page 238 Emx and Nfi genes regulate cortical development and axon guidance in the telencephalon......Page 244 DISCUSSION......Page 256 Schizophrenia susceptibility genes and their neurodevelopmental implications: focus on neuregulin 1......Page 260 DISCUSSION......Page 269 Focal brain malformations: a spectrum of disorders along the mTOR cascade......Page 274 DISCUSSION......Page 286 Final Discussion......Page 290 Contributor Index......Page 296 Subject Index......Page 298