جدال‌ها در نوروپاتی دیابتی (جلد ۱۲۷) (مرور بین‌المللی نوروبیولوژی، جلد ۱۲۷)

This latest volume in the __International Review of Neurobiology__ series, provides a comprehensive overview of the state-of-the-art research on the topic. It reviews the current knowledge and understanding in the field, presenting a starting point for researchers and practitioners entering the field. * Offers a comprehensive overview of state-of-the-art research on diabetic neuropathy * Provides personal critiques from experts in each field * Provides a running commentary by editors throughout the book * Explores a range of topics including mechanisms of nerve damage, neuropathic pain, new therapies, clinical trials, and animal models of diabetic neuropathy Content: Series Page Page ii Copyright Page iv Contributors Pages xi-xii Preface Pages xiii-xvi D. Tomlinson Chapter One - A Brief Introduction to the History and Controversies of Clinical Trials in Diabetic Neuropathy Pages 3-8 N.A. Calcutt, P. Fernyhough Chapter Two - Neuropathy in the DCCT/EDIC—What Was Done Then and What We Would Do Better Now Pages 9-25 R. Pop-Busui, C. Martin Chapter Three - The Perfect Clinical Trial Pages 27-41 V. Bril Chapter Four - An Introduction to the History and Controversies of Animal Models of Diabetic Neuropathy Pages 45-52 N.A. Calcutt, P. Fernyhough Chapter Five - Can Diabetic Neuropathy Be Modeled In Vitro? Pages 53-87 N.J. Gardiner, O.J. Freeman Chapter Six - Alternatives to the Streptozotocin-Diabetic Rodent Pages 89-112 M.A. Yorek Chapter Seven - An Introduction to the History and Controversies of the Pathogenesis of Diabetic Neuropathy Pages 115-120 P. Fernyhough, N.A. Calcutt Chapter Eight - Glucotoxic Mechanisms and Related Therapeutic Approaches Pages 121-149 S. Yagihashi Chapter Nine - Sensory Neurodegeneration in Diabetes: Beyond Glucotoxicity Pages 151-180 D.W. Zochodne Chapter Ten - Promoting Neuronal Tolerance of Diabetic Stress: Modulating Molecular Chaperones Pages 181-210 S.M. Emery, R.T. Dobrowsky Chapter Eleven - Painful Diabetic Neuropathy: Prevention or Suppression? Pages 211-225 S.M. Todorovic Chapter Twelve - New Directions in Diabetic Neuropathy: Evolution or Extinction? Pages 229-234 P. Fernyhough, N.A. Calcutt Chapter Thirteen - Alternative Quantitative Tools in the Assessment of Diabetic Peripheral and Autonomic Neuropathy Pages 235-285 A.I. Vinik, C. Casellini, M.-L. Névoret Chapter Fourteen - Wherefore Art Thou, O Treatment for Diabetic Neuropathy? Pages 287-317 R.A. Malik Index Pages 319-327 Contents of Previous Volumes Pages 329-375

This latest volume in the International Review of Neurobiology series, provides a comprehensive overview of the state-of-the-art research on the topic. It reviews the current knowledge and understanding in the field, presenting a starting point for researchers and practitioners entering the field.

• Offers a comprehensive overview of state-of-the-art research on diabetic neuropathy
• Provides personal critiques from experts in each field
• Provides a running commentary by editors throughout the book
• Explores a range of topics including mechanisms of nerve damage, neuropathic pain, new therapies, clinical trials, and animal models of diabetic neuropathy