Constitutional Oncogenetics

In the age of genomics, oncogenetics is a growing discipline. It is defined as the identification and management of families where there is a suspected hereditary risk of cancer. This relatively new discipline is part of a modern medicine that aims to be both preventive and predictive. Constitutional Oncogenetics gives precise descriptions of the main syndromes that cause a predisposition for cancer. The first part examines the most common syndromes in the majority of the world, including the heightened hereditary risk of breast and ovarian cancer and Lynch syndrome. The second part introduces less common infracentesimal syndromes, such as Bloom syndrome and Fanconi syndrome. This book is intended for oncogenetic practitioners and other specialists, as well as medical students. Cover Table of Contents List of Tables List of Illustrations Copyrights Foreword Introduction PART 1 Major Syndromes 1 Hereditary Breast and Ovarian Cancer Syndrome Including Isolated Ovarian Cancers 2 Lynch Syndrome 3 Neurofibromatosis 4 Familial Adenomatous Polyposis 5 Endocrine Neoplasia 6 Hereditary Paraganglioma– pheochromocytoma 7 Birt–Hogg–Dubé Syndrome RASopathies 9 Familial Malignant Melanoma 10 Gorlin Syndrome PART 2 Infracentesimal Syndromes 11 Li—Fraumeni Syndrome 12 Ataxia–telangiectasia 13 Hyperparathyroidism 14 Hamartomatous Polyposis Syndromes 15 Fanconi Syndrome 16 Hereditary Diffuse Gastric Cancer 17 Von Hippel–Lindau Disease 18 Xeroderma Pigmentosum 19 Hereditary Papillary Renal Carcinoma 20 Retinoblastoma 21 Carney Complex 22 Hematological Malignancies 23 Familial Pituitary Adenomas 24 Bloom Syndrome 25 Werner Syndrome Appendix Summary of the Book References Index