Conformation in Biology and Drug Design : The Peptides: Analysis, Synthesis, Biology, Vol. 7

The Peptides: Analysis, Synthesis, Biology, Volume 7: Conformation in Biology and Drug Design focuses on the analysis of peptides, emphasizing the use of physical methods in peptide conformational analysis and the relationship of conformational properties of peptides to biological properties. This book consists of nine chapters. Chapter 1 provides a brief overview of the perspective on the application of physical methods to peptide conformational analysis. The use of circular dichroism (CD) spectroscopy to examine the conformational properties of peptides in solution is elaborated in Chapter 2, while the use of fluorescence spectroscopy to examine the special relationships of aromatic side-chain groups to one another is discussed in Chapter 3. In Chapter 4, the use of various theoretical methods to calculate the conformations of peptides is described. The methods used to stimulate peptide conformations and dynamics are outlined in Chapter 5. The last four chapters examine various aspects of the use of nuclear magnetic resonance (NMR) in peptide conformational analysis. This volume is suitable for biologists, specialists, and researchers interested in peptides and proteins. Content: THE PEPTIDES: Analysis, Synthesis, Biology, Page ii Front Matter, Page iii Copyright, Page iv Contributors, Page ix Preface, Pages xi-xiv, Victor J. Hruby Nomenclature and Abbreviations, Pages xv-xix Chapter 1 - A Perspective on the Application of Physical Methods to Peptide Conformational–Biological Activity Studies, Pages 1-14, VICTOR J. HRUBY Chapter 2 - Circular Dichroism of Peptides, Pages 15-114, ROBERT W. WOODY Chapter 3 - Application of Fluorescence Techniques in Studies of Peptide Conformations and Interactions, Pages 115-164, PETER W. SCHILLER Chapter 4 - Theoretical Methods in the Analysis of Peptide Conformation, Pages 165-212, S. SCOTT ZIMMERMAN Chapter 5 - Theoretical Simulation of Conformation, Energetics, and Dynamics of Peptides, Pages 213-299, A.T. HAGLER Chapter 6 - Paramagnetic Metal Ions as Nuclear Magnetic Resonance Probes of Peptide Conformation in Solution, Pages 301-353, ROBERT E. LENKINSKI, JERRY D. GLICKSON Chapter 7 - Nuclear Magnetic Resonance Studies of Peptide–Macromolecule Interactions, Pages 355-403, MICHAEL BLUMENSTEIN Chapter 8 - Solid-State Nuclear Magnetic Resonance of Peptides, Pages 405-436, STANLEY J. OPELLA, LILA M. GIERASCH Chapter 9 - Modern Nuclear Magnetic Resonance Spectroscopy of Peptides, Pages 437-473, HORST KESSLER, WOLFGANG BERMEL, ARNDT MÜLLER, KARL-HEINZ POOK Index, Pages 475-495