Concepts in Clinical Pharmacokinetics

Understanding the science of pharmacokinetics is a challenge for many pharmacy students and practitioners. Concepts in Clinical Pharmacokinetics, now in its 7th edition, has helped thousands by simplifying this essential, but complex, subject to reflect current practice. The 7th edition has been revised by Robin Southwood, PharmD, BC-ADM, CDE; Virginia H. Fleming, PharmD, BCPS; and Gary Huckaby, PharmD; all experts in clinical pharmacy education. Together, they have updated and expanded the text to include the latest information and insights on concepts through extensive use of correlates, figures, and review questions. Inside you will find: • 15 easy-to-follow lessons, perfect for a semester • Practice quizzes to help chart progress • Enhanced discussion of hemodialysis • A phenytoin “cheat sheet” to help you through the calculations maze • New vancomycin cases based on higher desired vancomycin levels and trough-only dose estimations • Expanded information on modified diet in renal disease formula versus Cockcroft-Gault formula methods • Factors to consider when choosing a dosing/body weight for various equations • Updated clinical correlates, discussion points, references, and questions/answers Concepts in Clinical Pharmacokinetics is the fundamental reference for learning the basic, foundational pharmacokinetics concepts and how to apply them in clinical practice. Title Page......Page 2 Copyright......Page 3 Table of Contents......Page 4 Preface......Page 6 A Note from the Authors on Using This Edition......Page 8 Abbreviations......Page 10 Lesson 1. Introduction to Pharmacokinetics and Pharmacodynamics......Page 12 Lesson 2. Basic Pharmacokinetics......Page 32 Lesson 3. Half-Life, Elimination Rate, and AUC......Page 42 Practice Set 1......Page 56 Lesson 4. Intravenous Bolus Administration, Multiple Drug Administration, and Steady-State Average Concentrations......Page 60 Lesson 5. Relationships of Pharmacokinetic Parameters and Intravenous Intermittent and Continuous Infusions......Page 76 Lesson 6. Two-Compartment Models......Page 92 Practice Set 2......Page 104 Lesson 7. Biopharmaceutics: Absorption......Page 110 Lesson 8. Drug Distribution and Protein Binding......Page 124 Lesson 9. Drug Elimination Processes......Page 136 Lesson 10. Nonlinear Processes......Page 156 Lesson 11. Pharmacokinetic Variation and Model-Independent Relationships......Page 166 Practice Set 3......Page 182 Lesson 12. Aminoglycosides......Page 186 Lesson 13. Vancomycin......Page 214 Lesson 14. Theophylline......Page 232 Lesson 15. Phenytoin and Digoxin......Page 242 Appendix A. Basic and Drug-Specific Pharmacokinetic Equations......Page 262 Appendix B. Supplemental Problems......Page 272 Appendix C. Glossary......Page 280 Index......Page 284