Computer applications in biotechnology : a postprint volume from the 6th International Conference, Garmisch-Partenkirchen, Germany, 14-17 May 1995

The 6th Computer Applications in Biotechnology (CAB6) conference was a continuation of 2 series of events: the IFAC symposia on Modelling and Control of Biotechnical Processes and the International Conferences on Computer Applications in Fermentation Technology. This conference provided the opportunity for both sides, leading researchers and industrial practitioners, in this interdisciplinary field to exchange new ideas and technology; concepts and solutions. This postprint volume contains all those papers which were presented at the conference. Content: Front Matter, Page i Copyright, Page ii 6th INTERNATIONAL CONFERENCE ON COMPUTER APPLICATIONS IN BIOTECHNOLOGY - CAB 6, Page iii STATISTICAL DATA-PROCESSING FROM ON-LINE LASER TUBIDIMETER AND AUTO-FEEDING OF NATURAL COMPLEX NUTRIENTS IN SEMI-BATCH CULTURES, Pages 1-5, Tsuneo Yamane, Yasuyuki Kadotani, Wataru Hibino, Kohji Miyamoto, Minoru Kominami MODEL-AIDED ON-LINE GLUCOSE MONITORING FOR COMPUTER-CONTROLLED HIGH CELL DENSITY FERMENTATIONS, Pages 6-11, M. Pfaff, E. Wagner, R. Wenderoth, U. Knüpfer, R. Guthke, D. Riesenberg DEPROTECTION MONITORING IN SPPS: CONDUCTIMETRIC VERSUS SPECTROPHOTOMETRIC TECHNIQUES, Pages 12-16, Silvio Bicciato, Andrea Bagno, Monica Dettin, Carlo Di Bello PROJECTIVE REFERENCE EVALUATION - THE RELIABLE EVALUATION TECHNIQUE FOR FLOW INJECTION ANALYSIS SIGNALS, Pages 17-23, B. Hitzmann, K. Schöngarth, A. Löhn, B. Weigel FEEDBACK CONTROL OF A RECOMBINANT FED-BATCH FERMENTATION USING ON-LINE HPLC MEASUREMENTS, Pages 24-28, V.M. SAUCEDO, S.C. VALENTINOTT, M.N. KARIM, H.W. COLLINS REAL-TIME RECURSIVE PARAMETER ESTIMATION FOR FAULT DETECTION IN FLOW-INJECTION ANALYSIS SYSTEMS, Pages 29-34, Xiaoan Wu, Karl-Heinz Bellgardt EXPLORATORY DIAGNOSIS OF LARGE-SCALE CHROMATOGRAPHIC PROCESSES BY PRINCIPAL COMPONENT ANALYSIS, Pages 35-40, R M Chandwani, N Thornhill, B Horstmann, P Kårsnãs, N J Titchener Hooker PATTERN RECOGNITION FOR PHASE DETECTION IN BIOPROCESSES, Pages 41-46, K. Gollmer, C. Posten HYBRID SIMULATION OF MICROBIAL BEHAVIOR COMBINING A STATISTICAL PROCEDURE AND FUZZY IDENTIFICATION OF CULTURE PHASES, Pages 47-52, Jun-ichi Horinchi, Michimasa Kishimoto Seed Data Analysis for Production Fermenter Performance Estimation, Pages 53-58, M. Ignova, J. Glassey, A.C. Ward, G.A. Montague, T.S. Irvine ARTIFICIAL NEURAL NETWORKS OF IMPROVED RELIABILITY FOR INDUSTRIAL PROCESS SUPERVISION, Pages 59-65, R. Simutis, I. Havlik, F. Schneider, M. Dors, A. Lübbert REACTION MECHANISMS AND CELL DENSITY ESTIMATORS FOR ANIMAL CELL CULTURES, Pages 66-71, V. Chotteau, G. Bastin, I.M.Y. Mareels, L. Fabry ADVANCED SUPERVISION OF MAMMALIAN CELL CULTURES USING HYBRID PROCESS MODELS, Pages 72-77, M. Dors, R. Simutis, A. Lübbert CONTROL OF CONTINUOUS FERMENTATION PROCESSES BY SLIDING MODE DESIGN, Pages 78-82, L. Cazzador, L. Mariani, M. Ignatova DESIGN OF A CONTROL STRATEGY FOR A LIPASE PRODUCTION PROCESS, Pages 83-88, S. Charbonnier, A. Cheruy DEVELOPMENT OF INTELLIGENT CONTROL SYSTEMS FOR BIOREACTORS, Pages 89-94, Kazuyuki Shimizu, Kaiming Ye NEURAL MODELS IN PREDICTIVE CONTROL, Pages 95-100, H.J.L. van Can, H.A.B. te Braake, C. Hellinga, K.Ch.A.M. Luyben, J.J. Heijnen MODELLING AND CONTROL OF A FED-BATCH FERMENTATION PROCESS USING NEURAL NETWORKS AND ITERATIVE LEARNING METHOD, Pages 101-106, B.S. Zhang, R. Tang, J.R. Leigh DYNAMICS AND CONTROL OF THE FED-BATCH PRODUCTION OF POLY-β-HYDROXYBUTYRATE BY Methylobacterium extorquens, Pages 107-112, Y. POMERLEAU, M. PERRIER, D. BOURQUE AN ADVANCED CONTROL METHOD BASED ON THE PATTERN RECOGNIZE AND NEURAL NETWORK FOR BIOPROCESS, Pages 113-117, Shuqing Wang, Wei Zou, Haibin Qu, Yibing Yang ON-LINE PHYSIOLOGICAL STATE RECOGNITION AND PARAMETER ESTIMATION IN THE METABOLIC REACTION MODEL USING ERROR VECTORS, Pages 118-123, Hiroshi Shimizu, Keigo Miura, Noboru Takiguchi, Suteaki Shioya, Ken-ichi SUGA MODELLING OF SHORT TERM CRABTREE-EFFECT IN BAKER'S YEAST, Pages 124-129, Manfred Rizzi, Michael Baltes, Werner Mailinger, Uwe Theobald, Matthias Reuss IN VIVO STATIONARY FLUX DETERMINATION USING 13C NMR ISOTOPE LABELLING EXPERIMENTS, Pages 130-135, W. Wiechert, A.A. de Graaf, A. Marx A KINETIC MODEL FOR THE PENICILLIN BIOSYNTHETIC PATHWAY IN PENICILLIUM CHRYSOGENUM, Pages 136-141, Jens Nielsen, Henrik S. Jørgensen COMPARING DIFFERENT MODELLING TECHNIQUES FOR THE ESCHERICHIA COLI FERMENTATION PROCESS, Pages 142-147, Mark R. Warnes, Jarmila Glassey, Gary A. Montague, Bo Kara DYNAMICAL MODELLING OF A BIOLOGICAL DETOXICATION PROCESS IN A FIXED BED REACTOR, Pages 148-153, Young Bo Hwang, D. Dochain MATHEMATICAL MODELS FOR GROWTH AND PRODUCTION OF SINGLE PELLETS AND PELLET POPULATIONS, Pages 154-158, R. KING, CH. BÜDENBENDER, G. OSWALD MODELLING OF STIRRED TANK BIOREACTORS, Pages 159-164, Sven Schmalzriedt, Marc Jenne, Matthias Reuss BIOFUEL CELL UTILIZING Saccharomyces cerevisiae – MODELLING of the PROCESS, Pages 165-170, Aarne Halme, Xia-Chang Zhang SIMULATION AND PROFIT ESTIMATION FOR BAKER'S YEAST CONTINUOUS PRODUCTION, Pages 171-176, J.Q. Yuan, S.R. Guo, K.-H. Bellgardt IMPROVEMENTS IN THE ON-LINE PARAMETER IDENTIFICATION OF BIOPROCESSES, Pages 177-182, R. Schneider, A. Munack NEURAL NETWORKS IN ESTIMATION AND CONTROL OF ANTIBODY PRODUCTION USING HYBRIDOMA CELLS IN FED-BATCH CULTURES, Pages 183-188, G.S. Oh, B. Eikens, T. Yoshida, M.N. Karim TEXTURE CHARACTERIZATION OF COLONIES ON SOLID SUBSTRATE, Pages 189-194, M.N. Pons, H. Mona, J.F. Drouin, H. Vivier PATTERN RECOGNITION METHODS FOR FERMENTATION DATABASE MINING, Pages 195-198, Gregory Stephanopoulos, Georg Locher, Michael Duff A SYSTEMATIC APPROACH TO STRUCTURED BIOLOGICAL MODELS, Pages 199-204, G. Breuel, E.D. Gilles, A. Kremling SUBSTRATE CONSUMPTION RATE - NEW CONCEPT OF MEASURING AND MONITORING IN THE ACTIVATED SLUDGE PROCESS, Pages 205-208, Jacek Czeczot BIOMASS ESTIMATION USING NEURAL NETWORKS AND THE EXTENDED KALMAN FILTER, Pages 209-212, G. Acuña, E. Latrille, G. Corrieu FLOW CYTOMETRIC MONITORING OF BACTERIAL CELL STATES UNDER GROWTH LIMITING CONDITIONS, Pages 213-216, Thomas Bley, Susann Müller, Andreas Lösche, Jörg-Uwe Ackermann, Wolfgang Babel STUDY OF SACCHAROMYCES CEREVISIAE YEAST CELLS BY FIELD FLOW FRACTIONATION AND IMAGE ANALYSIS, Pages 217-220, A. Litzén, G.M. Kresbach, M.N. Pons, M. Ehrat, H. Vivier NEW HARDWARE AND SOFTWARE CONCEPTS FOR FULLY AUTOMATED ANALYSIS AND DATA PROCESSING, Pages 221-225, Alfons Riek, Werner Mailinger, Martina Schütz, Manfred Rizzi, Matthias Reuss DEVELOPMENT OF ENZYMATIC AUTOANALYZERS FOR MONITORING BIOTECHNOLOGICAL PROCESSES, Pages 226-229, S.B. Itsygin, A.N. Khalutkin, E.R. Ralys, D.D. Greenshpan, V.V. Biryukov INTERACTIVE EVALUATION OF NMR SPECTRA FROM IN VIVO ISOTOPE LABELLING EXPERIMENTS, Pages 230-233, R. Wittig, M. Möllney, W. Wiechert, A.A. de Graaf THE ON-LINE COMPARISON OF A MEASURED VS CALCULATED OXYGEN MASS TRANSFER COEFFICIENT - A USEFUL PARAMETER FOR FAULT DIAGNOSIS, Pages 234-238, D R Walwyn AN EVOLUTIONARY ALGORITHM FOR INITIAL STATE AND PARAMETER ESTIMATION IN COMPLEX BIOCHEMICAL MODELS, Pages 239-242, Karsten Schmidt, Steven H. Isaacs Maximum Virginiamycin Production Strategy and its Realization in batch Cultivation of Streptomyces virginiae by Autoregulator Addition, Pages 243-246, Suteaki SHIOYA, Young Kook YANG, Hiroshi SHIMIZU, Ken-ich SUGA, Takuya NIHIRA, Yasuhiro YAMADA IDENTIFIABILITY OF BIOKINETIC MODELS IN AN ACTIVATED SLUDGE PROCESS, Pages 247-250, P. Vanrolleghem, M. Van Daele, D. Dochain SIMULATION OF PROFIT OPTIMIZATION FOR INDUSTRIAL BAKER'S YEAST CONTINUOUS FERMENTATION, Pages 251-254, S.R. Guo, J.Q. Yuan, K.-H. Bellgardt PERFORMANCE OF INHIBITION FUNCTIONS WITH TOTAL INHIBITION CONCENTRATION, Pages 255-258, Y.B. Hwang, D. Dochain, G. Bastin MODEL-BASED ESTIMATION OF REACTION RATES IN STIRRED TANK BIOREACTORS, Pages 259-264, R. Oliveira, E.C. Ferreira, S. Feyo de Azevedo EDUCATION OF BEER BREWING PHYSIOLOGY AND TECHNOLOGY USING PSI SIMULATION LANGUAGE, Pages 265-268, Jaroslav Votruba, Miloš Kmínek, Marta Palatová SIMULATION SUPPORT FOR OPERATOR CONTROL OF THE WASTEWATER TREATMENT PLANT, Pages 269-272, Mieczyslaw Metzger SLIDING ADAPTIVE CONTROL OF BIOTECHNOLOGICAL PROCESSES, Pages 273-276, Laurent Karsenti, Georges Bastin BIOREACTOR MODELING AND CONTROL BY PRINCIPAL COMPONENT BASED NEURAL NETWORKS, Pages 277-280, Ž. Kurtanjek DEVELOPMENT OF A MYSTAT WITH ONLINE-SIMULATION METHODS, Pages 281-286, R. Luttmann, G. Bitzer, D. Müller, U. Scheffler, U. Friedriszik STOCK AND CONCENTRATION DYNAMICS OF ACTIVATED SLUDGE PROCESSES, Pages 287-291, R. Tenno, P. Uronen STRATEGIES FOR OPTIMAL DISSOLVED OXYGEN (DO) CONTROL, Pages 292-295, R. Mikler, W. Kramer, O. Doblhoff - Dier, K. Bayer COMPUTER AIDED DESIGN OF LINEARIZING CONTROL FOR BIOPROCESSES, Pages 296-300, Bernard REMOND, Arlette CHERUY BioX++ – NEW RESULTS AND CONCEPTIONS CONCERNING THE INTELLIGENT CONTROL OF BIOTECHNOLOGICAL PROCESSES, Pages 301-304, K.D. BETTENHAUSEN, S. GEHLEN, P. MARENBACH, H. TOLLE FUZZY CONTROL OF THE SUBSTRATE CONCENTRATION IN A BIOREACTOR, Pages 305-308, M. Boll, F. Dörrscheidt, D.C. Hempel EXPERT SYSTEM WITH FRAME DATA FOR INFERENCE OF SUITABLE CULTURE CONDITION, Pages 309-312, Michimasa Kishimoto, Hideyuki Suzuki NEURAL NETWORKS IN LYSINE FERMENTATION, Pages 313-316, S. Linko, Y.-H. Zhu, P. Linko IDENTIFICATION AND CONTROL DURING FERMENTATION START-UP - A METHOD TO AVOID SYNCHRONOUS GROWTH IN CONTINOUOUS CULTURES, Pages 317-320, Hanne Møller, Sten Bay Jørgensen MODELING AND CONTROL OF A CONTINUOUS BIOREACTOR WITH CROSS-FLOW FILTRATION, Pages 321-325, Ying Zhao, Sigurd Skogestad SIMULATION OF CELL CYCLE DEPENDENT GROWTH AND METABOLISM IN ANIMAL CELL FERMENTATION, Pages 326-329, B. Szperalski, F. Geipel, U. Behrendt, J. Wahl AN ARTIFICIAL INTELLIGENCE FRAMEWORK OF GENERIC CELL MODELLING, Pages 330-333, PENGCHENG FU, JOHN P. BARFORD STRUCTURED DYNAMIC MODELLING OF VIRAL INFECTION IN CELL CULTURE, Pages 334-337, CS Sanderson, SH Ong, L Johnson, JP Barford, GW Barton A TRANSFER-FUNCTION REPRESENTATION FOR FLUX RESPONSES OF A CONTROLLED METABOLIC PATHWAY TO INFLUX AND EFFLUX RATES, Pages 338-341, Naoto Sakamoto PROTEOLYTIC ACTIVITY OF HYBRIDOMA CULTURES-A SIMULATION STUDY, Pages 342-346, I.M. Møller, P. Frederiksen, C. Emborg OPTIMISATION OF BIOTECHNICAL PROCESSES UTILISING INTEGRATED METHODS FOR EXPERIMENTAL AND SAMPLING DESIGN, Pages 347-350, Andrea Holmberg, Heikki Haario, Marjut Pokkinen, Raimo Oinas APPLICATION OF SYMBOLIC COMPUTATION METHODS FOR STABILITY ANALYSIS OF MICROBIAL MIXED POPULATIONS, Pages 351-355, Klaus Mauch, Manfred Rizzi, Naruemol Noisommit-Rizzi, Matthias Reuss BEST-KIT; Development of Biochemical Engineering System Analyzing TooI-KIT (Kyushu Institute of Technology), Pages 356-359, Masahiro Okamoto, Yoshimitsu Morita OBJECT ORIENTED DESIGN OF AN ON LINE DATA MANAGER FOR HYBRID BIOPROCESS CONTROL, Pages 360-363, C. Hausmann, W. Wiechert, J. Ebert AUTHOR INDEX, Pages 364-365 KEYWORD INDEX, Pages 366-367