Computational Modelling of Biomechanics and Biotribology in the Musculoskeletal System: Biomaterials and Tissues (Woodhead Publishing Series in Biomaterials Book 81)

Modelling is an important aspect of the design process for biomaterials and medical devices. By effectively modelling biomaterials and implants before their implantation, it is now possible to predict certain implant-tissue reactions, degradation and wear. Consequently, computational modelling is becoming increasingly important in the design and manufacture of biomedical materials, allowing scientists to more accurately tailor their materials' properties for the in vivo environment. Computational modelling of biomechanics and biotribology in the musculoskeletal system begins with an introducti. Read more... Content: Cover; Computational Modelling of Biomechanics and Biotribology in the Musculoskeletal System: Biomaterials and Tissues; Copyright; Contents; Contributor contact details; Woodhead Publishing Series in Biomaterials; Foreword; Preface; Part I Generic modelling of biomechanics and biotribology; 1 Fundamentals of computational modelling of biomechanics in the musculoskeletal system; 1.1 Computational approach and its importance; 1.2 Generic computational approach and important considerations; 1.3 Computational methods and software; 1.4 Future trends; 1.5 Sources of further information and advice 1.6 References2 Finite element modeling in the musculoskeletal system: generic overview; 2.1 The musculoskeletal (MSK) system; 2.2 Overview of the finite element (FE) method; 2.3 State-of-the-art FE modeling of the MSK system; 2.4 Key modeling procedures and considerations; 2.5 Challenges and future trends; 2.6 References; 3 Joint wear simulation; 3.1 Introduction; 3.2 Classification of wear; 3.3 Analytic and theoretical modelling of wear; 3.4 Implementation of wear modelling in the assessment of joint replacement; 3.5 Validating wear models; 3.6 Future trends; 3.7 References 3.8 Appendix: useful tablesPart II Computational modelling of musculoskeletal cells and tissues; 4 Computational modeling of cell mechanics; 4.1 Introduction; 4.2 Mechanobiology of cells; 4.3 Computational descriptions of whole-cell mechanics; 4.4 Liquid drop models; 4.5 Solid elastic models; 4.6 Power-law rheology model; 4.7 Biphasic model; 4.8 Tensegrity model; 4.9 Semi-flexible chain model; 4.10 Dipole polymerization model; 4.11 Brownian ratchet models; 4.12 Dynamic stochastic model; 4.13 Constrained mixture model; 4.14 Bio-chemo-mechanical model; 4.15 Computational models for muscle cells 4.16 Future trends4.17 References; 5 Computational modeling of soft tissues and ligaments; 5.1 Introduction; 5.2 Background and preparatory results; 5.3 Multiscale modeling of unidirectional soft tissues; 5.4 Multiscale modeling of multidirectional soft tissues; 5.5 Mechanics at cellular scale: a submodeling approach; 5.6 Limitations and conclusions; 5.7 Acknowledgments; 5.8 References; 6 Computational modeling of muscle biomechanics; 6.1 Introduction; 6.2 Mechanisms of muscle contraction: muscle structure and force production; 6.3 Biophysical aspects of skeletal muscle contraction 6.4 One-dimensional skeletal muscle modeling6.5 Causes and models of history-dependence of muscle force production; 6.6 Three-dimensional skeletal muscle modeling; 6.7 References; 7 Computational modelling of articular cartilage; 7.1 Introduction; 7.2 Current state in modelling of articular cartilage; 7.3 Comparison and discussion of major theories; 7.4 Applications and challenges; 7.5 Conclusion; 7.6 References; 8 Computational modeling of bone and bone remodeling; 8.1 Introduction; 8.2 Computational modeling examples of bone mechanical properties and bone remodeling Abstract: Modelling is an important aspect of the design process for biomaterials and medical devices. By effectively modelling biomaterials and implants before their implantation, it is now possible to predict certain implant-tissue reactions, degradation and wear. Consequently, computational modelling is becoming increasingly important in the design and manufacture of biomedical materials, allowing scientists to more accurately tailor their materials' properties for the in vivo environment. Computational modelling of biomechanics and biotribology in the musculoskeletal system begins with an introducti Computational Modelling of Biomechanics and Biotribology in the Musculoskeletal System reviews how a wide range of materials are modelled and how this modelling is applied. Computational modelling is increasingly important in the design and manufacture of biomedical materials, as it makes it possible to predict certain implant-tissue reactions, degradation, and wear, and allows more accurate tailoring of materials' properties for the in vivo environment. Part I introduces generic modelling of biomechanics and biotribology with a chapter on the fundamentals of computational modelling of biomechanics in the musculoskeletal system, and a further chapter on finite element modelling in the musculoskeletal system. Chapters in Part II focus on computational modelling of musculoskeletal cells and tissues, including cell mechanics, soft tissues and ligaments, muscle biomechanics, articular cartilage, bone and bone remodelling, and fracture processes in bones. Part III highlights computational modelling of orthopedic biomaterials and interfaces, including fatigue of bone cement, fracture processes in orthopedic implants, and cementless cup fixation in total hip arthroplasty (THA). Finally, chapters in Part IV discuss applications of computational modelling for joint replacements and tissue scaffolds, specifically hip implants, knee implants, and spinal implants; and computer aided design and finite element modelling of bone tissue scaffolds. This book is a comprehensive resource for professionals in the biomedical market, materials scientists and mechanical engineers, and those in academia. Covers generic modelling of cells and tissues; modelling of biomaterials and interfaces; biomechanics and biotribology Discusses applications of modelling for joint replacements and applications of computational modelling in tissue engineering Computational Modelling Is Increasingly Important In The Design And Manufacture Of Biomedical Materials, As It Makes It Possible To Predict Certain Implant-tissue Reactions, Degradation, And Wear, And Allows More Accurate Tailoring Of Materials' Properties For The In Vivo Environment. Computational Modelling Of Biomechanics And Biotribology In The Musculoskeletal System Reviews How A Wide Range Of Materials Are Modelled And How This Modelling Is Applied. Part I Introduces Generic Modelling Of Biomechanics And Biotribology With A Chapter On The Fundamentals Of Computational Modelling Of Biomechanics In The Musculoskeletal System, And A Further Chapter On Finite Element Modelling In The Musculoskeletal System. Chapters In Part Ii Focus On Computational Modelling Of Musculoskeletal Cells And Tissues, Including Cell Mechanics, Soft Tissues And Ligaments, Muscle Biomechanics, Articular Cartilage, Bone And Bone Remodelling, And Fracture Processes In Bones. Part Iii Highlights Computational Modelling Of Orthopedic Biomaterials And Interfaces, Including Fatigue Of Bone Cement, Fracture Processes In Orthopedic Implants, And Cementless Cup Fixation In Total Hip Arthroplasty (tha). Finally, Chapters In Part Iv Discuss Applications Of Computational Modelling For Joint Replacements And Tissue Scaffolds, Specifically Hip Implants, Knee Implants, And Spinal Implants; And Computer Aided Design And Finite Element Modelling Of Bone Tissue Scaffolds.-- Annotation Modelling is an important aspect of the design process for biomaterials and medical devices. By effectively modelling biomaterials and implants before their implantation, it is now possible to predict certain implant-tissue reactions, degradation and wear. Consequently computational modelling is becoming increasingly important in the design and manufacture of biomedical materials, allowing scientists to more accurately tailor their materials¿ properties for the in vivo environment. The book begins with an introduction to the field and the software and technologies. Part one provides readers with an introduction to the field. Part two covers generic modelling of cells and tissues whilst chapters in part three discuss modelling of biomaterials and interfaces. Part four reviews biomechanics and biotribology with chapters in part five discussing applications of modelling for joint replacements and tissue engineering Part 1 provides readers with an introduction to the field. Part 2 covers generic modelling of cells and tissues whilst chapters in part three discuss modelling of biomaterials and interfaces. Part 4 reviews biomechanics and biotribology with chapters in part 5 discussing applications of modelling for joint replacements and tissue engineering.