Comprehensive organic synthesis : selectivity, strategy & efficiency in modern organic chemistry / volume 1, Additions to C-X [pi]-bonds, part 1 / ed. Stuart L. Schreiber

Trost Barry M. Comprehensive Organic Synthesis - Selectivity, strategy and efficiency in modern organic chemistry in 9 Vol. Volume 1 - Additions to C-X π-Bonds, Part 1 [reprint 1991] 2007 [pdf 987sc 989c. 21.38mb]The development of more effective routes to known materials and the production of new materials are important goals in many areas, including electronics, agriculture, medicine and textiles. Organic synthesis is central to achieving these goals. Comprehensive Organic Synthesisdraws together the common themes that underlie the many apparently disparate areas of organic chemistry which underpin synthetic strategies, thus providing a comprehensive overview of this important discipline.The contributions have been organized to reflect the way in which synthetic chemists approach a problem. In terms of organic molecules, the work is divided into formation of carbon-carbon bonds, introduction of heteroatoms and heteroatom interconversions. Thus, Volumes 1-5 focus on carbon-carbon formation, but also include aspects of heteroatom introduction. Volumes 6-8 concentrate on interconversion of heteroatoms, but also deal with exchange of carbon-carbon bonds for carbon-heteroatom bonds. Organization of the chapters is along the theme of selectivity, which is a critical question in determining the suitability of a synthetic method. Volume 9 contains cumulative author and subject indexes.Comprehensive Organic Synthesis will appeal to a wide audience. The set will be an essential reference work for all those seeking information on the solution of synthetic problems, whether they be experienced practitioners or chemists whose major interests lie outside organic synthesis. In addition, synthetic chemists requiring the essential facts in new areas, as well as students completely new to the field, will find Comprehensive Organic Synthesis an invaluable source, providing authoritative accounts of the essential facts and concepts.

the Development Of More Effective Routes To Known Materials And The Production Of New Materials Are Important Goals In Many Areas, Including Electronics, Agriculture, Medicine And Textiles. Organic Synthesis Is Central To Achieving These Goals. comprehensive Organic Synthesisdraws Together The Common Themes That Underlie The Many Apparently Disparate Areas Of Organic Chemistry Which Underpin Synthetic Strategies, Thus Providing A Comprehensive Overview Of This Important Discipline.

the Contributions Have Been Organized To Reflect The Way In Which Synthetic Chemists Approach A Problem. In Terms Of Organic Molecules, The Work Is Divided Into Formation Of Carbon-carbon Bonds, Introduction Of Heteroatoms And Heteroatom Interconversions. Thus, Volumes 1-5 Focus On Carbon-carbon Formation, But Also Include Aspects Of Heteroatom Introduction. Volumes 6-8 Concentrate On Interconversion Of Heteroatoms, But Also Deal With Exchange Of Carbon-carbon Bonds For Carbon-heteroatom Bonds. Organization Of The Chapters Is Along The Theme Of Selectivity, Which Is A Critical Question In Determining The Suitability Of A Synthetic Method. Volume 9 Contains Cumulative Author And Subject Indexes.

comprehensive Organic Synthesis Will Appeal To A Wide Audience. The Set Will Be An Essential Reference Work For All Those Seeking Information On The Solution Of Synthetic Problems, Whether They Be Experienced Practitioners Or Chemists Whose Major Interests Lie Outside Organic Synthesis. In Addition, Synthetic Chemists Requiring The Essential Facts In New Areas, As Well As Students Completely New To The Field, Will Find comprehensive Organic Synthesis An Invaluable Source, Providing Authoritative Accounts Of The Essential Facts And Concepts.

The development of more effective routes to known materials and the production of new materials are important goals in many areas, including electronics, agriculture, medicine and textiles. Organic synthesis is central to achieving these goals. "Comprehensive Organic Synthesis"draws together the common themes that underlie the many apparently disparate areas of organic chemistry which underpin synthetic strategies, thus providing a comprehensive overview of this important discipline. The contributions have been organized to reflect the way in which synthetic chemists approach a problem. In terms of organic molecules, the work is divided into formation of carbon-carbon bonds, introduction of heteroatoms and heteroatom interconversions. Thus, Volumes 1-5 focus on carbon-carbon formation, but also include aspects of heteroatom introduction. Volumes 6-8 concentrate on interconversion of heteroatoms, but also deal with exchange of carbon-carbon bonds for carbon-heteroatom bonds. Organization of the chapters is along the theme of selectivity, which is a critical question in determining the suitability of a synthetic method. Volume 9 contains cumulative author and subject indexes. "Comprehensive Organic Synthesis" will appeal to a wide audience. The set will be an essential reference work for all those seeking information on the solution of synthetic problems, whether they be experienced practitioners or chemists whose major interests lie outside organic synthesis. In addition, synthetic chemists requiring the essential facts in new areas, as well as students completely new to the field, will find "Comprehensive Organic Synthesis" an invaluable source, providing authoritative accounts of the essential facts and concepts. Volume 1 provides a detailed survey of reactions that entail the 1,2-addition of nonstabilized carbanion equivalents of carbonyl, imino and thiocarbonyl functionality. Emphasis has been placed on those reagents that result in highly selective addition reactions. Methods are reported to select, for example, one carbonyl group over another in the same molecule, or to add preferentially a fragment to one (enantiotopic of diastereotopic) face of a carbonyl group. Processes that result from an initial addition to the C=X functional group, for example alkenations and rearrangements, are also covered in this volume. Covers carbon-to-carbon single bond forming reactions involving sp3, sp2 and sp carbon centers, but only those which do not involve additions to C-X p-bonds. This book compares and contrasts the alkylation reactions of various types of sp3 carbon nucleophiles and also covers vinyl and alkynyl carbanions. Vol. 1.-2. Additions to C-X[pi]-Bonds - v. 3. Carbon-carbons̳-Bond formation v. 4. Additions to and substitutions at C-C[pi]-Bonds v. 5. Combining C-C[pi]-Bonds v. 6. Heteroatom manipulation v. 7. Oxidation v. 8. Reduction v. 9. Cumulative indexes. In this chapter the focus is primarily on the recent structural work concerning carbanions of alkali and alkaline earth cations that are widely utilized in synthetic organic chemistry.