حساب‌های کامل کشف و توسعه داروهای یکپارچه: نمونه‌های اخیر از صنعت داروسازی (جلد اول) (سری سمینارهای acs)

Content: ForewordPreface1. Discovery and Development of GDC-0994: A Selective and Efficacious Small Molecule Inhibitor of ERK1/22. Preclinical Identification and Development of AM-6138: An Inhibitor of BACE1 for the Treatment of Alzheimer's Disease3. Discovery and Chemical Development of Verubecestat, a BACE1 Inhibitor for the Treatment of Alzheimer's Disease4. Discovery and Chemical Development of JNJ-50138803, a Clinical Candidate BACE1 Inhibitor5. Discovery and Development of Ruzasvir: An Investigational Next Generation Pan-Genotype HCV Nonstructural Protein 5A (NS5A) Inhibitor for the Cure of Hepatitis C Virus Infections6. AZD6564, Discovery of a Potent 5-Substituted Isoxazol-3-ol Fibrinolysis Inhibitor and Development of an Enantioselective Large-Scale Route for Its Preparation7. Design and Development of the Glucokinase Activator AZD16568. Development of a Reversible P2Y12R Antagonist, AZD1283-Discovery Research and Large-Scale Chemistry9. Discovery, Process Development, and Scale-Up of a Benzoxazepine-Containing mTor InhibitorEditors' BiographiesAuthor IndexSubject Index This book comprehensively explains drug discovery and process chemistry all at once, with fewer limits than ever before. This volume covers the process of drug development from discovery to application.