Comparative Biochemistry of Parasites: Proceedings of the International Symposium on the Comparative Biochemistry of Parasites Organized by the Janssen Research Foundation and Held at Janssen Pharmaceutica, Beerse, Belgium, September 1-3, 1971

Comparative Biochemistry of Parasites contains the proceedings of an international symposium organized by the Janssen Research Foundation and held at Janssen Pharmaceutica in Belgium on September 1-3, 1971. The symposium reviewed progress in the understanding of the physiology and biochemistry of parasites such as protozoa and helminths. Organized into 34 chapters, this volume begins with an overview of early research on parasite biochemistry before turning to a discussion of antischistosomal drugs and their biochemical effects on parasites. The reader is then introduced to the biochemistry of carbohydrates in nematodes and cestodes; neurotransmitters in trematodes; pharmacological aspects and biochemical effects of tetramisole; the mechanism of action of berenil (Diminazene) and related compounds; and dihydrofolate reductases in parasitic protozoa and helminths. Other chapters focus on the loss of fatty acid biosynthesis in flatworms, the cytochrome system in Kinetoplastidae, oxidative phosphorylation in Moniezia mitochondria, and the role of non-heme iron in cestode respiration. Scientists, particularly physiologists and biochemists, will find this book an invaluable source of information on parasite physiology and biochemistry. Content: Inside Front Cover , Page ii Front Matter , Page iii Copyright , Page iv PARTICIPANTS , Pages ix-xii PREFACE , Page xiii , H. Vanden Bossche 1 - GLIMPSES AT THE EARLY DAYS OF PARASITE BIOCHEMISTRY , Pages 1-23 , Theodor von Brand 2 - BIOCHEMICAL EFFECTS OF ANTISCHISTOSOMAL DRUGS , Pages 25-32 , Ernest Bueding 3 - COMPARATIVEE BIOCHEMISTRY OF CARBOHYDRATES IN NEMATODES AND CESTODES , Pages 33-47 , Howard J. Saz 4 - THE UTILIZATION OF CARBON DIOXIDE BY MONIEZIA EXPANSA: ASPECTS OF METABOLIC REGULATION , Pages 49-79 , C. Bryant 5 - HORMONES, THE ENVIRONMENT, AND DEVELOPMENT IN NEMATODES , Pages 81-94 , K.G. Davey 6 - NEUROTRANSMITTERS IN TREMATODES , Pages 95-99 , Ernest Bueding, James Bennett 7 - PHARMACOLOGICAL ASPECTS OF TETRAMISOLE , Pages 101-115 , J.M. Van Nueten 8 - BIOCHEMICAL EFFECTS OF TETRAMISOLE , Pages 117-125 , H. Vanden Bossche 9 - RECENT STUDIES ON THE MECHANISM OF ACTION OF BERENIL (DIMINAZENE) AND RELATED COMPOUNDS , Pages 127-138 , B.A. Newton 10 - BIOCHEMICAL EFFECTS OF THE ANTHELMINTIC DRUG MEBENDAZOLE , Pages 139-157 , H. Vanden Bossche 11 - KINETOPLAST DNA. STRUCTURE AND FUNCTION , Pages 159-166 , M. Steinert, Suzanne Van Assel 12 - ORGANIZATION OF THE DNA IN THE KINETOPLAST OF TRYPANOSOMATIDAE , Pages 167-184 , E. Delain, Ch. Brack, A. Lacome, G. Riou 13 - DNA OF KINETOPLASTIDAE: A COMPARATIVE STUDY , Pages 185-198 , B.A. Newton, J.K. Burnett 14 - SOME STUDIES ON THE DNA OF PLASMODIUM KNOWLESI , Pages 199-218 , W.E. Gutteridge, P.I. Trigg 15 - DIHYDROFOLATE REDUCTASES IN PARASITIC PROTOZOA AND HELMINTHS , Pages 219-233 , Julian J. Jaffe 16 - PHYSIOLOGICAL ADAPTABILITY OF MALARIA PARASITES , Pages 235-258 , R.E. Howells, W. Peters, C.A. Homewood 17 - CYTOCHEMICAL AND BIOCHEMICAL STUDIES OF THE INTESTINAL CELLS OF ASCARIS SUUM , Pages 259-273 , M. Borgers, H. Vanden Bossche 18 - FACTORS INFLUENCING THE MOVEMENT OF MATERIALS ACROSS THE INTESTINE OF ASCARIS , Pages 275-282 , Calvin G. Beames Jr., Gary A. King 19 - ACID PHOSPHATASES IN THE INTESTINAL CELLS OF TWO NEMATODE LARVAE: ANISAKIS SP. AND TRICHINELLA SPIRALIS , Pages 283-295 , E.J. Ruitenberg 20 - STUDIES ON ACID HYDROLASES AND ON CATALASE OF THE TRYPANOSOMATID CRITHIDIA LUCILIAE , Pages 297-315 , Y. Eeckhout 21 - STRUCTURAL AND BIOCHEMICAL CHANGES IN NIPPOSTRONGYLUS BRASILIENSIS DURING DEVELOPMENT OF IMMUNITY TO THIS NEMATODE IN RATS , Pages 317-327 , D.L. Lee 22 - ADAPTATIONS IN OXIDATIVE METABOLISM DURING THE TRANSFORMATION OF TRYPANOSOMA RHODESIENSE FROM BLOODSTREAM INTO CULTURE FORM , Pages 329-342 , I.B.R. Bowman, H.K. Srivastava, I.W. Flynn 23 - EFFECTS OF BONGKREKIC ACID ON MALARIA PARASITES ( PLASMODIUM LOPHURAE ) DEVELOPING EXTRACELLULARLY IN VITRO , Pages 343-350 , W. Trager 24 - CARBOHYDRATE METABOLISM IN ENTAMOEBA HISTOLYTICA , Pages 351-358 , R.E. Reeves 25 - BIOCHEMISTRY OF COCCIDIA , Pages 359-381 , J.F. Ryley 26 - LOSS OF FATTY ACID BIOSYNTHESIS IN FLATWORMS , Pages 383-393 , Franz Meyer, Haruko Meyer 27 - RECENT STUDIES ON THE CHARACTERIZATION OF THE CYTOCHROME SYSTEM IN KINETOPLASTIDAE , Pages 395-415 , George C. Hill 28 - CYTOCHROMES IN ASCARIS AND MONIEZIA , Pages 417-432 , K.S. Cheah 29 - ROLE OF NON-HEME IRON IN CESTODE RESPIRATION , Pages 433-444 , Eugene C. Weinbach 30 - EFFECTS OF ANTHELMINTICS ON P 32 ESTERIFICATION IN HELMINTH METABOLISM , Pages 445-454 , Howard J. Saz 31 - STUDIES ON THE PHOSPHORYLATION IN ASCARIS MITOCHONDRIA , Pages 455-468 , H. Vanden Bossche 32 - THE INFLUENCE OF THE LIPOPHILIC AND ELECTRONIC CHARACTER OF SUBSTITUTED PHENOLS ON THE EFFECTORS OF ASCARIS SUUM MITOCHONDRIA , Pages 469-478 , J.P. Tollenaere 33 - OXIDATIVE PHOSPHORYLATION IN MONIEZIA MITOCHONDRIA , Pages 479-490 , K.S. Cheah 34 - SUMMARY AND OUTLOOK , Pages 491-494 , W. Trager SUBJECT INDEX , Pages 495-516