Colorectal Cancer: Evidence-based Chemotherapy Strategies (Current Clinical Oncology)

Recent advances in the understanding of the biology of colorectal cancer have radically transformed the treatment options available to clinicians, leaving textbooks written only two years ago completely out of date. This evidence-based and data-driven guide presents reviews of cutting-edge therapies for colorectal cancer, all articulated by leading experts in the field. This integrated and focused consideration of colorectal management includes reviews of cytotoxic chemotherapy, targeted biologic therapies, as well as updates on adjuvant chemotherapy for colon cancer and combined modality management of rectal cancers. Attention is also focussed on the role of potentially curative multi-modality management of liver metastases, with considerations of the role of liver resection and discussions of non-surgical ablative therapies. Supportive issues are also considered, including contributions from experts in pain management and oncology nursing. The reviews presented here are concise, up-to-date, and are organized with the treating practitioner in mind. Opening chapters outline contemporary thinking on the biology of colorectal cancer, and methods of possible prevention utilizing chemoprevention and screening. Subsequent chapters present cutting-edge uses of cytotoxic chemotherapy and review the potential for incorporating innovative biological therapy. Ample consideration is given to practical issues related to colorectal chemotherapy, specifically radiological evaluation of colorectal cancer treatment and supporting patients through chemotherapy, including pain management. The concluding chapter is devoted to the exploration of and implications of emerging new drug paradigms and their potential impact on colorectal cancer treatment. This unique text offers the practitioner a concise, authoritative reference, so that recent advancements and understanding may be digested, disseminated, and rapidly applied to the treatment of the colorectal cancer patient. Molecular Biology Of Colon Cancer / William M. Grady -- Chemoprevention Of Colorectal Cancer / Yu-ning Wong ...[et Al.] -- Colorectal Cancer Screening And Surveillance / Arnold J. Markowitz -- Cytotoxic Chemotherapy For Metastatic Colorectal Cancer / M. Wasif Saif, Richard Kim, And Edward Chu -- Integration Of Antiangiogenic Strategies In Colorectal Cancer Treatment / John M. Strother And Charles D. Blanke -- The Role Of Egfr Inhibition In Colorectal Cancer / Nabeel Shalan And Paulo M. Hoff -- Second-line Strategies In The Treatment Of Patients With Metastatic Colorectal Cancer / Anthony B. El-khoueiry And Heinz-josef Lenz. Adjuvant Chemotherapy For Colon Cancer / Bert H. O'neil ... [et Al.] -- Management Of Locally Advanced Rectal Cancer / Yu Jo Chua And David Cunningham -- Rationale For Adjuvant And Neoadjuvant Chemotherapy In The Resection Of Liver Metastases / Axel Grothey And Steven A. Alberts -- Percutaneous Radiofrequency Ablation In The Management Of Patients With Colorectal Cancer / Karen Brown -- Colorectal Cancer Imaging / Sean D. Curran And Laurence H. Schwartz -- Nursing Issues In Colorectal Cancer Chemotherapy / Ellen Hollywood And Deborah Semple -- Pain Management In The Colorectal Cancer Patient / Vivek Tim Malhotra. Novel Agents And New Paradigms For Colorectal Cancer / Chris Takimoto And Russell Kruzelock. Edited By Leonard B. Saltz. Includes Bibliographical References And Index. Management options for patients with colorectal cancer have undergone d- matic changes over the past decade. Whereas at the start of 1996 only one drug, 5-Fluorouracil, was available for the treatment of this disease, a mere 10 yr later, six drugs are licensed for use in colorectal cancer, and others are in the late phases of clinical development. Likewise, surgical and ablative options, as well as an array of supportive medications, have shown substantial progress and undergone a dramatic proliferation over the past decade. With the increased number of therapeutic options from which to choose, the clinician is better able to offer effective therapy to the patient with colorectal cancer. The clinician is challenged, however, to keep up with the rapidly changing landscape and the rapidly emerging data that shape the options for treatment today and tom- row. In this text, leaders in the management of colorectal cancer review the current literature that has led us to where we are today. Critical evaluations of the data are offered, and evidence-based recommendations are made.