Color atlas of melanocytic : lesions of the skin

As essential a text for GPs as for dermatologists, this book is an atlas-like representation of the various forms of melanocytic skin lesions associated with cutaneous melanomas and other pigmented skin tumors. It is a comprehensive and up-to-date text on the practical issues surrounding the management of individuals with these lesions. It encompasses the classical methods of morphology such as the clinical and dermoscopic examination and dermatopathology. The book also deals with the most up-to-date diagnostic approaches such as laser scanning in-vivo microscopy and automated diagnosis. The visual ‘atlas’ includes superb clinical, dermoscopic and histopathologic images. Contents......Page 8 I.1.2 The Benign/Malignant Threshold in Morphology......Page 16 References......Page 17 I.2.2 ABCDE Criteria and Other Diagnostic Methods......Page 18 I.3.2 Physical Aspects......Page 22 I.3.3 Equipment for Dermoscopy......Page 23 I.3.4.2 Blood Vessels......Page 24 I.3.5.3 Globules......Page 26 I.3.5.5 Streaks......Page 27 I.3.5.11 Comedo-like Openings (Crypts, Pseudofollicular Openings)......Page 28 I.3.5.18 Multiple Blue-Gray Globules......Page 29 I.3.6 Differential Diagnosis of Pigmented Lesions of the Skin......Page 30 I.3.7.3 Dermoscopic Structures......Page 34 References......Page 36 I.4.1 I ntroduction......Page 38 I.4.2.3 Particular Morphological Types of Melanoma......Page 40 I.4.3.1 Melanocytic Tumors Biopsied in Newborns or Shortly After Birth......Page 41 I.4.3.2 Proliferations of Melanocytes Within Chronic Sun-Damaged Skin......Page 42 I.4.3.4 Proliferations of Melanocytes Within Mucosal Epithelium (Genital and Oral Mucosa)......Page 43 I.4.3.5 Melanocytic Proliferations at Other Special Skin Sites......Page 44 I.4.4.2 Nodular Proliferations of Melanocytes Within Congenital Nevi......Page 45 I.4.4.4 Proliferations of Melanocytes Associated with Prominent Inflammatory Response and/or Regression......Page 46 I.4.4.6 Atypical Melanocytic Nevi with Degenerative Changes ("Ancient" Melanocytic Nevi)......Page 47 I.4.4.7 Melanocytic Proliferations with "Spitzoid" Morphology......Page 48 I.4.5 Conclusion......Page 49 References......Page 50 II.1.1 Fundamentals and Imaging Parameters for Reflectance-Mode Laser Scanning Confocal Microscopy......Page 54 II.1.3.1 Melanocytic Nevi......Page 55 II.1.3.2 Cutaneous Melanoma......Page 57 II.1.4 Accuracy Studies on Confocal Diagnoses of Melanocytic Malignancy......Page 58 II.1.6 Conclusion......Page 59 References......Page 60 II.2.2 Clinical Images......Page 62 II.2.4.2 In-Vivo Confocal Laser Scanning Microscopy......Page 63 II.2.4.4 Levels of Evidence......Page 64 References......Page 65 II.3.2 Analysis of Multispectral Images of Skin Lesions from the MelaFind Database......Page 67 II.3.3 Examples of Wavelength-Dependent Lesion Parameters......Page 69 II.3.4 Lesion Classification Based on Multispectral Images......Page 70 References......Page 71 II.4.1 Introduction and Definition......Page 72 II.4.4 Teledermatopathology......Page 73 II.4.2 Teledermatology on the Web......Page 74 References......Page 75 III.1.2 The Life of Congenital Nevi......Page 76 III.1.3 The Life of Acquired Nevi......Page 77 III.1.4 Clark Nevi: Are They Truly Precursors of Melanoma?......Page 79 References......Page 80 III.2.3 Dermoscopic Criteria......Page 81 III.2.5 Histopathology......Page 84 III.2.7.1 Case 1......Page 85 III.2.7.3 Case 3......Page 86 III.2.7.4 Case 4......Page 87 References......Page 89 III.3.6 Management......Page 90 References......Page 92 III.4.1 Definition......Page 93 III.4.3 Dermoscopic Criteria......Page 95 III.4.5 Histopathology......Page 97 III.4.5 Case Study......Page 99 References......Page 100 III.5.1 Definition......Page 102 III.5.3 Dermoscopic Criteria......Page 103 III.5.6 Histopathology......Page 106 III.5.8.1 Case 1......Page 107 III.5.8.2 Case 2......Page 109 References......Page 110 III.6.2 Clinical Features......Page 112 III.6.6 Management......Page 113 References......Page 114 III.7.3 Dermoscopic Criteria......Page 117 III.7.7 Case Study......Page 118 References......Page 119 III.8.2 Etiology and Pathogenesis......Page 121 III.8.3 Clinical Features......Page 122 III.8.3.1 Clinical Variants......Page 124 III.8.4 Dermoscopic Criteria and Other Diagnostic Modalities......Page 125 III.8.7 Management......Page 126 III.8.8 Case Study......Page 129 References......Page 131 III.9.2 Clinical Features......Page 134 III.9.5 Histopathology......Page 135 III.9.6 Management......Page 136 III.9.7 Case Study......Page 137 References......Page 138 III.10.2 Clinical Features......Page 139 III.10.5 Histopathology......Page 141 References......Page 142 III.11.2 Clinical Features......Page 144 III.11.4 Relevant Clinical Differential Diagnosis......Page 145 III.11.6 Management......Page 146 III.11.7 Case Study......Page 147 References......Page 148 III.12.2.1 Nevi......Page 150 III.12.2.2 Melanoma......Page 151 III.12.4 Conclusion......Page 152 References......Page 153 III.13.4 Relevant Clinical Differential Diagnoses......Page 154 III.13.7.2 Case 2......Page 155 References......Page 156 III.14.2.2 Pink Nevus......Page 157 III.14.3.1 Black Nevus......Page 158 III.14.4.2 Pink Nevus......Page 159 III.14.6.2 Pink Nevus......Page 160 References......Page 161 III.15.3 Dermoscopic Criteria......Page 162 III.15.5 Management......Page 164 References......Page 165 III.16.1 Definition......Page 166 III.16.2 Clinical Features......Page 167 III.16.3 Dermoscopic Criteria......Page 168 III.16.4 Relevant Clinical Differential Diagnosis......Page 173 III.16.5 Histopathology......Page 174 III.16.6 Management......Page 175 References......Page 176 III.17.2.1 Clinical Features......Page 179 III.17.2.3 Management and Prognosis......Page 180 III.17.3.2 Diagnostic Investigation......Page 181 III.17.4.1 Clinical Features......Page 182 III.17.5.2 Diagnosis......Page 183 III.17.6.2 Diagnosis......Page 184 References......Page 185 III.18.3 Dermoscopic Criteria......Page 188 III.18.5 Histopathology......Page 190 III.18.7.1 Case 1......Page 191 III.18.7.2 Case 2......Page 192 References......Page 195 III.19.3 Dermoscopic Criteria......Page 196 III.19.5 Histopathology......Page 198 References......Page 199 IV.1.2 Global Epidemiology......Page 200 IV.1.4.1 Skin Colour......Page 201 IV.4.3 Naevi......Page 202 IV.1.4.5 Sun Exposure......Page 203 IV.1.4.8 Occupation......Page 204 IV.1.5.2 Secondary Prevention......Page 205 References......Page 206 IV.2.1 Definition......Page 211 IV.2.2 Clinical Features......Page 212 IV.2.4 Relevant Clinical Differential Diagnosis......Page 213 IV.2.5 Histopathology......Page 214 IV.2.7 Case Study......Page 215 References......Page 217 IV.3.2 Hypomelanotic and Amelanotic Melanoma......Page 219 IV.3.4 Clinical Features......Page 220 IV.3.5 Dermoscopic Criteria......Page 222 IV.3.8 Vascular Patterns in Amelanotic Melanoma......Page 223 IV.3.9 Morphological Changes of Vessels During Tumor Growth......Page 224 IV.3.10.1 The Way to Diagnosis of Amelanotic Melanoma......Page 225 IV.3.10.2 Strategies for Detecting Amelanotic Melanoma......Page 226 References......Page 227 IV.4.1 Introduction and Definition......Page 228 IV.4.2 Clinical Features......Page 229 IV.4.4 Histopathology......Page 230 References......Page 234 IV.5.2 Clinical Features......Page 236 IV.5.3 Dermoscopic Criteria......Page 237 IV.5.4 Melanoma Simulating Seborrheic Keratosis......Page 238 IV.5.8 Melanoma Simulating Spitz Nevi......Page 239 IV.5.16 Management......Page 240 References......Page 242 IV.6.2 Clinical Features......Page 244 IV.6.5 Histopathology......Page 245 IV.6.7 Case Study......Page 246 References......Page 247 IV.7.3 Dermoscopic Criteria......Page 248 IV.7.6 Management......Page 249 IV.7.7 Case Study......Page 250 References......Page 251 IV.8 Melanoma of the Trunk and Limbs Including Superficial and Nodular Melanoma......Page 252 IV.8.2.2 Clinical Signs......Page 253 IV.8.3 Superficial Spreading Melanoma......Page 254 IV.8.3.1 Borders in Superficial Spreading Melanoma......Page 255 IV.8.5 Dermoscopic Criteria......Page 258 IV.8.10.2 Globules and Dots......Page 259 IV.8.11 Dermoscopic Findings in Nodular Melanoma......Page 260 IV.8.13.1 Differential Diagnosis in SSM......Page 261 IV.8.13.2 Differential Diagnosis in Nodular Melanoma......Page 262 IV.8.14.1 Radial Growth Phase......Page 263 IV.8.14.2 Vertical Growth Phase......Page 264 IV.8.15.1 Melanoma Screening and Identification of High-Risk Persons......Page 265 IV.8.15.3 Physical Examination......Page 266 IV.8.16.2 Sentinel Node Biopsy......Page 267 IV.8.18 Case Study......Page 268 References......Page 271 IV.9.2 Clinical Features......Page 275 IV.9.4.4 Vascular Patterns......Page 276 IV.9.5.2 Management......Page 277 References......Page 279 IV.10.2 Clinical Features......Page 280 IV.10.3 Dermoscopic Criteria......Page 281 IV.10.7 Case Study......Page 282 References......Page 283 IV.11.2 Clinical Features......Page 285 IV.11.4 Relevant Clinical Differential Diagnoses......Page 286 IV.11.4.1 Melanonychia Striata......Page 287 IV.11.4.2 Achromic Nail Apparatus Tumoral Syndrome......Page 288 IV.11.7.1 Case Study 1: Type 1......Page 289 IV.11.7.2 Case Study 2: Type 2......Page 291 References......Page 293 V.1.2 Clinical Features......Page 294 V.1.3 Dermoscopic Criteria......Page 295 IV.1.6 Management......Page 299 References......Page 300 V.2.3 Dermoscopic Criteria......Page 301 V.2.5 Histopathology......Page 303 References......Page 304 V.3.1.2 Clinical Features......Page 305 V.3.1.5 Histopathology......Page 306 V.3.2.4 Relevant Clinical Differential Diagnosis......Page 307 V.3.3.4 Relevant Clinical Differential Diagnosis......Page 308 References......Page 309 V.4.1 Definition......Page 310 V.4.2.2 Actinic Keratosis......Page 311 V.4.3.1 Squamous Cell Carcinoma......Page 312 V.4.3.3 Bowen's Disease......Page 313 V.4.5.2 Actinic Keratosis......Page 314 V.4.6.2 Actinic Keratosis......Page 315 References......Page 316 V.5.2 Hemangiomas......Page 318 V.5.2.1 Cherry Hemangioma......Page 319 V.5.3.3 Dermoscopic Criteria......Page 320 V.5.3.5 Histopathology......Page 321 V.5.4.1 Solitary Angiokeratoma......Page 322 V.5.5.1 Subungual Hematoma......Page 323 V.5.6 Case Study......Page 324 References......Page 326 V.6.2 Clinical Features......Page 328 V.6.3 Dermoscopic Criteria......Page 330 V.6.4 Relevant Clinical Differential Diagnosis......Page 334 V.6.5 Histopathology......Page 337 V.6.7.3 Dermoscopy......Page 338 V.6.7.5 Histopathology......Page 340 V.6.7.6 Management......Page 341 References......Page 342 C......Page 344 K......Page 345 N......Page 346 S......Page 347 X......Page 348 Morphologic Dimension In The Diagnosis Of Melanocytic Skin Lesions -- Clinical Examination Of Melanocytic Neoplasms Including Abcde Criteria -- Dermoscopic Examination -- Melanoma: The Morphological Dimension -- Laser-scanning Confocal Microscopy -- Automatic Diagnosis -- Multispectral Image Analysis -- Teledermatology -- Life Of Melanocytic Nevi -- Acral Nevus -- Agminated Nevus -- Blue Nevus -- Atypical (dysplastic) Nevus -- Combined Nevus -- Congenital Melanocytic Nevi -- Melanocytic Nevi On The Genitalia And Melanocytic Nevi On Other Special Locations -- Halo Nevus -- Irritate Nevus And Meryerson's Nevus -- Melanocytic Lesions In Darker Racial Ethnic Groups -- Miescher Nevus -- Nevi With Particular Pigmentation: Black, Pink, And White Nevus -- Recurrent Nevus -- Spitz Nevus And Its Variants -- Syndromes Involving Melanocytic Lesions -- Nail Apparatus Nevus (subungual Nevus, Nail Matrix Nevus) -- Unna Nevus -- Epidemiology Of Melanoma -- Acral Melanoma -- Amelanotic Melanoma -- Early Evolution Of Melanoma (small-diameter Melanoma) -- False-negative Melanomas -- Genital Melanoma -- Melanoma Of The Face -- Melanoma Of The Trunk And Limbs Including Superficial And Nodular Melanoma -- Cutaneous Metastatic Melanoma -- Scalp Melanoma -- Nail Apparatus Melanoma (subungual Melanoma, Nail Matrix Melanoma) -- Pigmented Basal Cell Carcinoma -- Dermatofibroma -- Lentigines Including Lentigo Simplex, Reticulated Lentigo And Actinic Lentigo -- Squamous Cell Carcinoma Including Actinic Keratosis, Bowens Disease, Keratoacanthoma, And Its Pigmented Variants -- Vascular Lesions -- Seborrheic Keratosis Including Lichen Planus-like Keratosis. Edited By H.p. Soyer ... [et Al.]. Includes Bibliographical References And Index. Melanocytic tumors of the skin deserve special a ll these features characterize the book as an attention because of the following important impressive contribution to the literature in the facts area of melanocytic tumors. My co-workers in Graz, Dr. H. Peter Soyer? Melanoma is frequent and early detection and Dr. r ainer Hofmann-Wellenhof, as well as is critical. Dr. Giuseppe a rgenziano from Naples and Dr.? a correct interpretation is necessary r obert Johr from Miami, together with many because the implications may be very international contributors who are all experts in serious. their respective disciplines, have produced a? it is a dynamically developing field where splendid piece of work which presents highly major progress has been made over the relevant information on a complex and cha- past decade. lenging subject. This book will greatly assist physicians in providing optimal care for pa - This atlas, written in a concise way, is a highly tients with melanocytic skin lesions. Covers the various faces of melanocytic skin lesions of cutaneous melanomas and other pigmented skin tumors. This work encompasses the classical methods of morphology such as the clinical and dermoscopic examination and dermatopathology as well as the diagnostic approaches such as laser scanning in-vivo microscopy and automated diagnosis