Cognitive impairment in major depressive disorder : clinical relevance, biological substrates, and treatment opportunities

Major Depressive Disorder (mdd) Is The Leading Cause Of Disability Globally In Both Developed And Developing Nations. The Staggering Economic Costs Attributable To Mdd Are Largely A Consequence Of Impairment In Role Function. Evidence Indicates That Disturbance In The Domain Of Cognitive Function In Individuals With Mdd Is The Principal Determinant Of Health Outcome. This Is The First Book To Comprehensively Explore The Domain Of Cognition In Mdd. The Literature Describing Cognitive Dysfunction Is Reviewed With Particular Focus On Clinical Determinants, Pathophysiology And Causative Factors. The Patient Subpopulations Most Susceptible Are Defined. A Summary Of Contemporary Assessment Tools For Research And Clinical Purposes Is Provided. Multimodality Treatments And Prevention Strategies Are Described. This Book Is An Invaluable Resource For Psychiatrists, Neuropsychologists And Other Members Of The Mental Health Team, As Well As For Policy Makers, Vocation Rehabilitation Experts, Disability Providers And Other Stakeholders Interested In Improving Health Outcomes In Mdd--provided By Publisher. Part I. Clinical Relevance Of Cognitive Dysfunction In Major Depressive Disorder -- 1. Does Cognitive Dysfunction Predate The Onset Of Incident Depression? / Julia Buthmann, Danielle S. Cha, And Roger S. Mcintyre -- 2. Understanding The Importance Of Cognitive Dysfunction And Cognitive Change In Major Depressive Disorder / Paul Maruff And Judith Jaeger -- 3. Cognition In Mdd : Implications For Primary Care / Larry Culpepper -- 4. Neurocognition In Pediatric Depression / Dwight Newton, Melanie R. Naiberg, And Benjamin I. Goldstein; -- 5. Neuroanatomy Of Cognition In Major Depressive Disorder / Guy M. Goodwin. 6. Hot And Cold Cognition In Major Depressive Disorder / Oliver J. Robinson, Jonathan P. Rosier, And Barbara J. Sahakian -- 7. Social Cognition And Emotional Processing In Major Depressive Disorder / Philippe Fossati And Sophie Hinfray -- 8. The Role Of Social Cognition In Major Depressive Disorder / Bernhard T. Baune And Michael Weightman -- 9. Are Cognitive Deficits In Major Depressive Disorder Progressive? Marie Laure Cléry-melin And Philip Gorwood -- 10. Implications Of Cognitive Impairments On Functional Outcomes In Major Depressive Disorder / Tracy L. Greer And Cassandra R. Hatt -- Part Ii. Underlying Biological Substrates Associated With Cognitive Dysfunction In Major Depressive Disorder. 11. Cognition And Biomarkers In Major Depressive Disorder : Endophenotype Or Epiphenomenon? / Shane J. Mcinerney, Phillip Gorwood, And Sidney H. Kennedy -- 12. Inflammation And Cognition In Major Depressive Disorder / Bernhard T. Baune -- 13. Hpa Axis And Cognitive Dysfunction In Mood Disorders / Rebecca Strawbridge And Allan H. Young -- 14. White Matter Neurobiology And Cognitive Dysfunction In Major Depressive Disorder / Geoffrey Chern-yee Tan And Kang Sim -- 15. Insulin Resistance And Implications For Hippocampal Volume/function The Default Mode Network / Heather A. Kenna, Tonita E. Wroolie, Danielle R. Balzafiore, And Natalie L. Rasgon. Part Iii. Evaluating Cognitive Dysfunction In Major Depressive Disorder -- 16. Measuring The Mind : Detecting Cognitive Deficits And Measuring Cognitive Change In Patients With Depression / John E. Harrison -- 17. Subjective Measures Of Cognitive Dysfunction In Major Depressive Disorder / Raymond W. Lam -- Part Iv. Treatment Opportunities For Ameliorating Cognitive Dysfunction In Major Depressive Disorder -- 18. Neuroscience Of Functional Outcomes And Treatment Targets In Major Depressive Disorder / Lisanne M. Jenkins, Amy Peters, Rachel H. Jacobs, And Scott A. Langenecker. 19. Treatment Of Cognitive Dysfunction In Adults With Major Depressive Disorder / Roger S. Mcintyre, Kahlood Syeda, And Danielle S. Cha -- 20. A Novel Treatment Targeting Cognitive Dysfunction In Mood Disorders / Kamilla W. Miskowiak -- ; 21. Cognitive Remediation For Major Depressive Disorder / Christopher R. Bowie -- 22. Exercise And Cognition / Guy Faulkner, Mark J. Duncan, And Mehala Subramaniapillai. Edited By Roger S. Mcintyre ; Associate Editor, Danielle S. Cha. Includes Bibliographical References And Index. Machine generated contents note: Preface Part I. Clinical Relevance of Cognitive Dysfunction in Major Depressive Disorder: 1. Does cognitive dysfunction predate the onset of incident depression? Julia Buthmann, Danielle S. Cha and Roger S. McIntyre 2. Understanding the importance of cognitive dysfunction and cognitive change in major depressive disorder Paul Maruff and Judith Jaeger 3. Cognitive dysfunction in adults with major depressive disorder Beatrice Bortolato, Cristiano Kohler and Andre Carvalho 4. Neurocognition in pediatric depression Dwight Newton, Melanie Naiberg and Benjamin Goldstein 5. Neuroanatomy of cognition in major depressive disorder (hot and cold) Guy M. Goodwin 6. Hot and cold cognition in major depressive disorder Oliver Robinson, Jonathan Rosier and Barbara Sahakian 7. Social cognition and emotional processing in major depressive disorder Philippe Fossati and Sophie Hinfray 8. The role of social cognition in major depressive disorder Bernhard Baune and Michael Weightman 9. Are cognitive deficits in major depressive disorder progressive? Philip Gorwood and Marie Laure Clery-Melin 10. Implications of cognitive impairments on functional outcomes in major depressive disorder Tracy L. Greer and Cassandra R. Hatt Part II. Underlying Biological Substrates Associated with Cognitive Dysfunction in Major Depressive Disorder: 11. Cognition and biomarkers in major depressive disorder (MDD): endophenotype or epiphenomenon? Shane McInerney, Phillip Gorwood and Sidney Kennedy 12. Inflammation and cognition in major depressive disorder Bernhard Baune 13. HPA axis and cognitive dysfunction in mood disorders Rebecca Strawbridge and Allan H. Young 14. White matter neurobiology and cognitive dysfunction in major depressive disorder Geoffrey Chern-Yee Tan and Kang Sim 15. Insulin resistance and implications for hippocampal volume/function the default mode network Heather A. Kenna, Tonita E. Wroolie, Danielle R. Balzafiore and Natalie L. Rasgon Part III. Evaluating Cognitive Dysfunction in Major Depressive Disorder: 16. Measuring the mind: detecting cognitive deficits and measuring cognitive change in patients with depression John Harrison 17. Subjective measures of cognitive dysfunction in major depressive disorder Raymond Lam Part IV. Treatment Opportunities for Ameliorating Cognitive Dysfunction in Major Depressive Disorder: 18. Neuroscience of functional outcomes and treatment targets in major depressive disorder Lisanne M. Jenkins, Amy Peters, Rachel H. Jacobs and Scott A. Langenecker 19. Treatment of cognitive dysfunction in adults with major depressive disorder Roger S. McIntyre, Kahlood Syeda and Danielle S. Cha 20. A novel treatment targeting cognitive dysfunction in mood disorders Kamilla W. Miskowiak 21. Cognitive remediation for major depressive disorder Christopher Bowie 22. Exercise and cognition Guy Faulkner, Mark Duncan and Mehala Subramaniapillai Index. Major Depressive Disorder (MDD) is the leading cause of disability globally in both developed and developing nations. The staggering economic costs attributable to MDD are largely a consequence of impairment in role function. Evidence indicates that disturbance in the domain of cognitive function in individuals with MDD is the principle determinant of health outcome. This is the first book to comprehensively explore the domain of cognition in MDD. The literature describing cognitive dysfunction is reviewed with particular focus on clinical determinants, pathophysiology and causative factors. The patient subpopulations most susceptible are defined. A summary of contemporary assessment tools for research and clinical purposes is provided. Multimodality treatments and prevention strategies are described. This book is an invaluable resource for psychiatrists, neuropsychologists and other members of the mental health team, as well as for policy makers, vocation rehabilitation experts, disability providers and other stakeholders interested in improving health outcomes in MDD.