Co-signal Molecules in T Cell Activation : Immune Regulation in Health and Disease

This book equips young immunologists and health professionals with a clear understanding of the fundamental concepts and roles of co-signal molecules and in addition presents the latest information on co-stimulation. The first part of the book is devoted to co-signal molecules and the regulation of T cells. Following an initial overview, subsequent chapters examine each co-signal molecule in turn and discuss the mechanisms by which co-signal molecules regulate the different types of T cell. The second part covers various clinical applications, including in autoimmune disease, neurological disorders, transplantation, graft-versus-host disease, and cancer immunotherapy. To date, co-stimulation blockade and co-inhibition blockade have shown beneficial effects and many additional clinical trials targeting co-signal molecules are ongoing. The mechanisms underlying these successful treatments are explained and the future therapeutic potential in the aforementioned diseases is evaluated. __Co-signal Molecules in T Cell Activation__ will be a valuable reference guide to co-stimulation for basic and clinical researchers in the fields of both immunology and pharmaceutical science. Front Matter ....Pages i-vi Front Matter ....Pages 1-1 Co-signal Molecules in T-Cell Activation (Miyuki Azuma)....Pages 3-23 The CD28–B7 Family of Co-signaling Molecules (Shigenori Nagai, Miyuki Azuma)....Pages 25-51 The TNF–TNFR Family of Co-signal Molecules (Takanori So, Naoto Ishii)....Pages 53-84 Signal Transduction Via Co-stimulatory and Co-inhibitory Receptors (Shuhei Ogawa, Ryo Abe)....Pages 85-133 Molecular Dynamics of Co-signal Molecules in T-Cell Activation (Takashi Saito)....Pages 135-152 Role of Co-stimulatory Molecules in T Helper Cell Differentiation (Michelle Schorer, Vijay K. Kuchroo, Nicole Joller)....Pages 153-177 Control of Regulatory T Cells by Co-signal Molecules (James Badger Wing, Christopher Tay, Shimon Sakaguchi)....Pages 179-210 Front Matter ....Pages 211-211 Stimulatory and Inhibitory Co-signals in Autoimmunity (Taku Okazaki, Il-mi Okazaki)....Pages 213-232 Co-signaling Molecules in Neurological Diseases (Pia Kivisäkk, Samia J. Khoury)....Pages 233-265 Costimulation Blockade in Transplantation (Melissa Y. Yeung, Tanja Grimmig, Mohamed H. Sayegh)....Pages 267-312 Cancer Immunotherapy Targeting Co-signal Molecules (Masao Nakajima, Koji Tamada)....Pages 313-326