Clinical trials in "early" breast cancer : methodological and clinical aspects of treatment comparisons : proceedings of a symposium, Heidelberg, Germany, 4th to 8th December, 1978

Front Matter....Pages I-VI Introduction....Pages 1-6 Prognostic Factors and Nosological Criteria of Breast Cancer from the Pathologist’s Point of View....Pages 7-19 Growth Rate of Tumours and Natural Life Expectancy....Pages 20-27 The reporting of non-significant results in clinical trials....Pages 28-39 Notes on Clinical Trial Methodology....Pages 40-44 The Cardiff Mastectomy Trial....Pages 45-60 Experiences from a Multicentric Trial of Adjuvant Chemotherapy....Pages 61-70 Thirty Years Experience with Breast Cancer Clinical Trials at the Christie Hospital in Manchester - Clinical Aspects -....Pages 71-74 Thirty Years Experience of Breast Cancer Trials in Manchester England — Statistical Aspects....Pages 75-86 The King’s/Cambridge Trial....Pages 87-103 Operable Breast Cancer with Positive Axillary Nodes: The Experience of the Milan Cancer Institute....Pages 104-111 Problems in Withdrawal of Patients in a Randomized Study, when Treatment in one of the Groups cannot be carried out....Pages 112-116 Treatment departure and survival analysis in a randomized trial on the value of pre- and postoperative radiotherapy in breast cancer....Pages 117-122 Stochastic Models in Clinical Trials....Pages 123-142 “Aspects of the Cox model in the analysis of survival data”....Pages 143-158 Time Dependent Covariates....Pages 159-171 A Large Sample Study of the Estimate for the Survival Distribution in Cox’x Regression Model....Pages 172-180 Comparing Treatments, Adjusting for Competing Risks....Pages 181-192 Why the Present Approach to Competing Risks Should be Abandoned....Pages 193-201 Competing Risk Methods in Early Breast Cancer Trials....Pages 202-212 Some Extensions of the Log Rank Test....Pages 213-223 Discussion....Pages 224-242 Back Matter....Pages 243-283