Clinical Pharmacology of Cerebral Ischemia (Contemporary Neuroscience)

A distinguished international panel of authors define our current understanding of neuronal damage after ischemia and critically review the significant recent developments and progress in cerebrovascular accident (CVA) drug trials, both in animal models and in the clinical setting. These leading basic and fundamental authorities survey such important new drugs as calcium-influx inhibitors, free-radical scavenging drugs, glutamate and glycinergic antagonists, and immune suppressors. They also evaluate all the latest findings concerning calcium homeostasis, glutamate toxicity, gene activation, and the role of free radicals, glycine, and hormones. Chapters devoted to the neuroimaging of stroke, clinical trials, and the role of cerebral immune activation complete this informative collection of cutting-edge reviews. Booknews Surveys the current understanding of neuronal damage after ischemia and critically reviews recent developments in cerebrovascular accident drug trials, both in animal models and the clinical setting. Looks at new drugs including calcium-influx inhibitors, free-radical scavengers, and immune suppressors, and evaluates findings in gene activation, hormones, and calcium homeostasis. Includes chapters on the neuroimaging of stroke, clinical trials, and the role of cerebral immune activation. For neurologists, and for pharmacologists and neurobiologists working on neurodegenerative disorders. Annotation c. by Book News, Inc., Portland, Or. In Clinical Pharmacology of Cerebral Ischemia, a distinguished international panel of authors define our current understanding of neuronal damage after ischemia and critically review the significant recent progress in cerebrovascular accident (CVA) drug trials, both for animal models and in the clinical setting. These leading basic science and medical authorities survey such important new drugs as calcium-influx inhibitors, free-radical scavenging drugs, glutamate and glycinergic antagonists, and immune suppressors. They also evaluate all the latest findings concerning calcium homeostasis, glutamate toxicity, gene activation, and the role of free radicals, glycine, and hormones. Chapters devoted to the neuroimaging of stroke, clinical trials, and the role of cerebral immune activation complete this informative collection of cutting-edge reviews Front Matter....Pages i-x Stroke....Pages 1-30 Imaging of Stroke....Pages 31-41 Clinical Aspects of Stroke and Therapeutic Strategies....Pages 43-66 Calcium Homeostasis, Nimodipine, and Stroke....Pages 67-99 Glutamate Neurotoxicity and Stroke....Pages 101-125 Glycine Antagonists for Treatment of Ischemic Brain Injury....Pages 127-151 Free Radical-Mediated Cerebral Damage After Hypoxia/Ischemia and Stroke....Pages 153-184 Genomic Responses Following Cerebral Ischemia....Pages 185-213 Hormonal Modulators of Cerebral Ischemia....Pages 215-234 Inflammatory Responses to Cerebral Ischemia....Pages 235-263 Animal Models Used in Cerebral Ischemia and Stroke Research....Pages 265-294 Back Matter....Pages 295-305